Pharmacokinetics of thiotepa in high-dose regimens for autologous hematopoietic stem cell transplant in Japanese patients with pediatric tumors or adult lymphoma

ConclusionThiotepa elimination was comparable in pediatric and adult patients with cancer. LowerVz in pediatric compared with adult patients was expected. HDT with thiotepa prior to autologous HSCT was well tolerated.Study registrationJapic CTI-163433.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research