Multiple primary malignancies for squamous cell carcinoma and adenocarcinoma of the esophagus.
Multiple primary malignancies for squamous cell carcinoma and adenocarcinoma of the esophagus. J Thorac Dis. 2019 Aug;11(8):3292-3301 Authors: Chen D, Fan N, Mo J, Wang W, Wang R, Chen Y, Hu J, Wen Z Abstract Background: Patients with esophageal cancer (EC) frequently have multiple primary cancers. We conducted the present study to assess the risk of multiple primary malignancies for patients with squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus and to investigate the influence of multiple primary tumors on the prognosis of EC patients. Methods: Using the data of 44,091 EC patients from the Surveillance Epidemiology and End Results (SEER) database, we calculated the standardized incidence ratios (SIRs) for overall multiple primary cancers and cancers at particular sites among EC survivors. The SIRs of esophageal SCC and AC patients were compared using Poisson regression. The Kaplan-Meier (KM) method was used for survival analysis. Results: Multiple primary cancer risk was significantly increased among both esophageal SCC and AC survivors (SIR: 2.28 and 1.57, respectively; P
A Holyrood committee finds 18% of cancer patients in June were not seen within the six-week target.
ConclusionsThe effect of therapy directed toward EGFR mutation or EML4 –ALK fusion gene might obscure the significant prognostic difference between M1b and M1c.
ConclusionApalutamide had manageable safety profile, without any DLT or any new safety signals, and favourable efficacy in Japanese mCRPC patients. Thus, it was ascertained to be an adequate dosage regimen in Japanese mCRPC patients.Trial registrationClinicalTrials.gov identifier: NCT02162836.
Attack on cancer drug comes amid near-halving in sector value since last year
Roche today announced that results from a number of studies from across its growing breast cancer portfolio will be presented at the San Antonio Breast Cancer Symposium (SABCS), from 10-14 December 2019.
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Nicoleta Badea, Mariela Madalina Craciun, Andreea Sofia Dragomir, Mihaela Balas, Anca Dinischiotu, Claudiu Nistor, Camelia Gavan, Daniela IonitaAbstractThe paper is concerned with obtaining nanosystems based on multiwalled carbon nanotubes (MWCNT), pemetrexed (Pm) and quercetin (Q) with antitumor action. MWCNT were contacted with ethanolic solutions of Pm/Q/Pm-Q, centrifuged and then filtered. The obtained nanosystems were structurally characterizedcaracterized by FTIR analysis. The physical stability of the nanosystem was assess...
Publication date: Available online 16 November 2019Source: Materials Chemistry and PhysicsAuthor(s): M. Ramadas, Khalil Ei Mabrouk, A.M. BallamuruganAbstractThree-dimensional (3D) porous apatite (HAP) scaffold has recently emerging as functional biomaterials in bone tissue engineering and wound healing. Here we present a study of the preparation of apatite (HAP) scaffold by gel-casting technique. The scaffold prepared as engineering constructs with non-uniform porosity and interconnected pores with a micro size of 2 μm–2.4 μm range. The resultant scaffolds were characterized in terms of crystalline phase...
(Canadian Medical Association Journal) The overall rate of new cancer cases is decreasing in men but increasing in women younger than 80 years, and obesity-related cancers are increasing in young people, according to a study on cancer trends in Canada from 1971 to 2015 published in CMAJ (Canadian Medical Association).
Patient autonomy, choice and control, and the potential role of clinicians, are central to whether UK cancer patients should be allowed access to medically assisted dying, argue experts.Medscape News UK
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