IJERPH, Vol. 16, Pages 3415: NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome
IJERPH, Vol. 16, Pages 3415: NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183415 Authors: Valerio Rosato Mario Masarone Marcello Dallio Alessandro Federico Andrea Aglitti Marcello Persico Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.
Authors: Mendenhall E, Musau A, Bosire E, Mutiso V, Ndetei D, Rock M Abstract Type 2 diabetes mellitus is a condition that both results from and produces social and psychological suffering. As 'diabetes' increases among low income patients in poorer nations, new challenges arise that drive, co-occur, and result from the condition. In this article, we describe how social suffering produces diabetes by way of addressing the varied social, psychological, and biological factors that drive diabetes and are reflected in diabetes experiences among patients seeking care at a public hospital in Nairobi, Kenya. We recruited ...
Authors: Marín-Sánchez A Abstract The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior...
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Shijie Dai, Shaozhong Liu, Chen Li, Zhifang Zhou, Zhimeng Wu
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Shuxian Hu, Rei Kuwabara, Martin Beukema, Michela Ferrari, Bart J. de Haan, Marthe T.C. Walvoort, Paul de Vos, Alexandra M. Smink
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Gayathri S., Varun P. Gopi, P. Palanisamy
Cachexia, a devastating wasting syndrome characterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increased energy expenditure, excess catabolism, and inflammation. Cachexia is associated with poor prognosis and high mortality and frequently occurs in patients with cancer, chronic kidney disease, infection, and many other illnesses. There is no effective treatment for this condition. Hypothalamic melanocortins have a potent and long-lasting inhibitory effect on feeding and anabolism, and pathophysiological processes increase melanocortin signaling tone, leadin...
Publication date: Available online 12 August 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Vinícius Dokkedal-Silva, José Carlos Fernandes Galduróz, Sergio Tufik, Monica L. Andersen
Publication date: Available online 12 August 2020Source: Microvascular ResearchAuthor(s): Xuping Niu, Qixin Han, Yanmin Liu, Juan Li, Ruixia Hou, Junqin Li, Kaiming Zhang
Publication date: Available online 12 August 2020Source: Microvascular ResearchAuthor(s): Sarah Zinn, Pieter Nelis, Katharina Minnebeck, Jens Hinder, Nicole Eter, Stefan-Martin Brand, Reinhold Gellner, Elena Vorona, Florian Alten, Boris Schmitz
CONCLUSION: Community-based screening and facility-based screening were complementary methods in reaching different population groups at high risk of developing type 2 diabetes. Community screening in particular reached more hard-to-reach groups with unfavorable risk profiles, making it a critical strategy for T2D prevention. More men should be recruited to intervention studies and screening initiatives to achieve a gender balance. PMID: 32746747 [PubMed - in process]
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