Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Liver disease constitutes the third most common cause of premature death in the UK, and its prevalence is substantially higher compared to other countries in Western Europe.[1 –3] Excess liver iron is associated with increased severity and progression of liver diseases including cirrhosis and hepatocellular carcinoma in individuals with non-alcoholic fatty liver disease (NAFLD), [4–6] and is the direct cause of liver disease in those with hereditary haemochromatosis a nd thalassaemia.[7,8] Observational associations have been described between excess liver iron content and several metabolic diseases such as high blood pressure, obesity, polycystic ovarian syndrome and type 2 diabetes - a condition recognised as dysmetabolic iron overload syndrome (DIOS) which aff ects up to 5-10% of the general population.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Authors: Joo I, Kim SY, Park HS, Lee ES, Kang HJ, Lee JM Abstract OBJECTIVE: To validate the diagnostic value of a new point shear-wave elastography method, S-shearwave elastography (S-SWE; Samsung Medison Co., Ltd.), in noninvasive assessment of liver fibrosis. MATERIALS AND METHODS: In this prospective multicenter study, liver stiffness (LS) measurements for 600 participants were obtained with both S-SWE and transient elastography (TE). The rates of unsuccessful LS measurements in S-SWE and TE were compared, and correlations between S-SWE and TE measurements were assessed. In 107 patients with histologic refe...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
Publication date: Available online 14 October 2019Source: Journal of Molecular LiquidsAuthor(s): Huiling Zheng, Xuemei Ren, Xiaodong Zhang, Gang Song, Diyun Chen, Changlun ChenAbstractNanoscale zero-valent iron (nZVI) has been widely considered as a promising permeable barrier material for remediating U(VI)-contaminated waters. Little information is available regarding co-removal of U(VI) and oxyanion contaminants by nZVI, yet in the majority of areas polluted by U(VI), co-existence of phosphate is found to be common especially in eutrophic water. Herein, the mutual influence of U(VI) and phosphate on the effectiveness of ...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
The purpose of this study was to evaluate the relationship between the circadian profile of the vasorelaxing substances calcitonin gene-related peptide (CGRP) and epoxyeicosatrienoic acids (EETs) and the vasconstrictive agent endothelin-1 (ET1) and the daily rhythms of cardiac hemodynamic indices (CHI) and baroreflex (BRS) in Wistar rats with 1 kidney-1 clip model of arterial hypertension (1K-1C AH). The animals were divided into 3 groups: I- sham-operated (SO), II- 4-week and III- 8-week 1K-1C AH rats. Plasma concentration of ET1, CGRP and EET ’s were investigated every 4 h. In conscious freely moving 1K-1C AH rats ...
Source: Journal of Circadian Rhythms - Category: Biology Source Type: research
Publication date: Available online 13 October 2019Source: Carbohydrate PolymersAuthor(s): Shaolei Kang, Hualin Wang, Li Xia, Minmin Chen, Linlin Li, Junfeng Cheng, Xingjiang Li, Shaotong JiangAbstractIn this work, a colorimetric film was designed for shrimp freshness monitoring by incorporating rose anthocyanins (RAs) in polyvinyl alcohol/okra mucilage polysaccharide (PVA/OMP) composite film. The presence of OMP changed the film-forming solution from Newtonian to non-Newtonian fluid. The addition of OMP and RAs decreased the crystalline of PVA due to the hydrogen bonds among RAs, OMP and PVA. An appropriate content of RAs ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
The company started in January 2018 in Israel and moved to San Francisco this year.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
We report the catalytic ozonation as a viable tool in the oxidative degradation of cresol isomers. SiO2-supported metal catalysts with 2.5 and 7.5 wt.% (Ni, Fe, Mn, V) were employed in this ozone initiated oxidation reactions. All catalysts were characterized using various analytical techniques such as XRD, FT-IR, SEM-EDX, TEM, ICP-OES, and BET-surface area analyses. XRD studies revealed the existence of Fe as Fe2O3 and Mn as Mn3O4 on the supports’ surface. EDX results displayed a dispersion homogeneity of the metals over the surface of SiO2 support, and the ICP-OES analysis confirm the concentration of a load...
Source: Catalysis Today - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Kubra Bilici, Abdullah Muti, Alphan Sennaroğlu, Havva Yagci AcarAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have been recently recognized as highly efficient photothermal therapy (PTT) agents. Here, we demonstrate, for the first time to our knowledge, dose and laser intensity dependent PTT potential of small, spherical, 3-aminopropyltrimethoxysilane coated cationic superparamagnetic iron oxide nanoparticles (APTMS@SPIONs) in aqueous solutions upon irradiation at 795 nm. Indocyanine gr...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Alcohol misuse is a common, disabling and costly issue worldwide. Internet-delivered cognitive behavior therapy (ICBT) has the potential to reduce the harms of alcohol misuse, particularly for individuals who are unable or unwilling to access face-to-face ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The objectives of this study were to examine the trends in intersection density in the US from 2007 to 2011 and assess the associations between intersection density and childho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Sexual and gender minority (SGM) youth are more likely to use alcohol than their heterosexual cisgender peers. At the same time, SGM youth experience sexuality- and gender identity-specific stressors known to exacerbate negative health outcomes. Though sch...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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