Understanding Follicular Output Rate (FORT) and its Implications for POSEIDON Criteria

Conclusion Considering the lack of efficient tool to accurately evaluate ovarian hypo-response, FORT proves to be a relevant and crucial quantitative, and qualitative index that should be used in everyday practice for the care and management of hypo-responders in ART. Impaired sensitivity to FSH revealed by FORT should be considered in the decision of treatment protocol, gonadotropin, and stimulation doses to be used for hypo-responders. Improving follicular responsiveness to FSH may also be a key to ameliorate prognosis of POSEIDON groups 3 and 4 “expected” poor responders. Reconsidering criteria for COH cancellation based on the output of follicle response to exogenous FSH rather than on the absolute counting of follicles recruited by treatment should be discussed. It is expected that a better understanding of low prognosis patients undergoing ART will help improve individualized ovarian stimulation management and identify more homogeneous populations for clinical trials, thereby, providing better tools with which to maximize IVF success rates. Author Contributions All authors listed have contributed to the work and approved the final version. JL and MG performed the literature research, wrote the paper and proofread it. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Esteves SC, R...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research