Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

This study is based on the hypothesis that altering endogenous antioxidant production and/or increasing OM3 rich diet consumption will improve energy metabolism and maintain insulin sensitivity. We tested the comparative metabolic effects of a diet rich in saturated fat (HFD) and an omega 3-enriched diet (OM3) in the newly developed ‘stress-less’ mice model that overexpresses the endogenous antioxidant catalase. Eight weeks of dietary intervention showed that mice overexpressing endogenous catalase compared to their wild-type controls when fed an OM3 enriched diet, in contrast to HFD, activated GPR120-Nrf2 cross-talk to maintain balanced energy metabolism, normal circadian rhythm, and insulin sensitivity. These findings suggest that redox regulation of GPR120/FFAR4 might be an important target in reducing risk of metabolic syndrome and associated diseases.Graphical abstractRedox regulation of GPR120-Nrf2 cross-talk in an OM3 fed catalase overexpressing mice: Overexpression of catalase in the Bob-Cat mice model coupled with an enriched diet of OM3 fatty acids was shown to be metabolically beneficial. Energy homeostasis seen in this model was the result of induction of the GPR120/FFAR4, which by interacting with Nrf2 pathway (redox-sensitive) in adipose tissue resulted in redox balance, improved insulin sensitivity, anti-inflammation, enhanced circadian rhythm, decreased body weight and healthy fat mass.
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research