Et-64 * pre-clinical assessment of dissociative steroids as dexamethasone substitute for treatment in diffuse intrinsic pontine glioma (dipg)

CONCLUSIONS: VPB15 has similar or better efficacy vs. dexamethasone (DEX) in reducing pro-inflammatory signals in brainstem glioma cells in vitro, and VBP15-treated DIPG mice show better survival compared to dexamethasone in vivo. These pilot results warrant more extensive pre-clinical testing and possibly development of a clinical trial.

Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Wells, E., Khambampati, M., Yadavilli, S., Damsker, J., Hoffman, E., Packer, R., Nazarian, J. Tags: EXPERIMENTAL AND BIOLOGICAL THERAPEUTICS (CLINICAL AND/OR LABORATORY) Source Type: research