Vincristine Induced Peripheral Neuropathy: A Randomized Controlled Trial Comparing Bolus Injections with One Hour Infusions during Induction in a Pediatric Population of Acute Lymphoblastic Leukemia and Hodgkin's Lymphoma

ConclusionsChildren treated for ALL or HL who receive VCR by means of one-hour infusions or bolus injections seem to be at equal or diminished risk of developing VIPN during induction therapy. Results of longer follow-up that includes the total treatment period should demonstrate whether VIPN occurs less frequently and/or is less severe in case VCR is administered through one-hour infusions compared to administrations by bolus injections.Figure.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Velde, M. E., van den Berg, M. H., Abbink, F., Segers, H., De Moerloose, B., van den Heuvel-Eibrink, M. M., van den Bos, C., van der Sluis, I. M., Kaspers, G. J. L. Tags: 614. Acute Lymphoblastic Leukemia: Therapy, excluding Transplantation Source Type: research