Risk of Post-Transplant Lymphoproliferative Disorders (PTLD) in Solid Organ Transplantation Patients with EBV Viremia

ConclusionIn this large cohort of SOT pts, <50% had EBV viremia post SOT with only 3% of pts with EBV viremia developing PTLD. EBV viral load of ≥4 log copies/mL at 2 and 6 months was associated with increased risk of PTLD. EBV monitoring post-transplant may benefit a subset of pts, and prospective studies are warranted to evaluate if preemptive treatment can reduce PTLD risk in high-risk pts.Figure.DisclosuresHill: Pharmacyclics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Genentech: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Research Funding; Pharmacyclics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees.

Source: Blood - November 21, 2018 Category: Hematology Authors: Sawalha, Y., McMichael, J., Rybicki, L., Sussman, T. A., Mejia Garcia, A. V., Dean, R. M., Pohlman, B., Hill, B. T., Jagadeesh, D. Tags: 627. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies: Poster III Source Type: research