Evaluation of Endocrine Complications in Beta-Thalassemia Intermedia Patients: A Cross Sectional Multi-Center Study

Conclusion: This study evaluated the largest cohort of BTI patients with endocrine disorders. Although BTI patients are non-transfusion dependent or only occasionally transfused, iron-overload due to increased intestinal iron absorption and enhanced bone marrow activity cause endocrine disorders and osteoporosis. This study demonstrate that although endocrine complications are less common in patients with BTI compared to data reported in literature in TM patients , a regular monitoring with timely diagnosis and proper management underscoring on osteoporosis and gonadal disorders are crucial to prevent endocrine complications in these patients.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Karimi, M., Zarei, T., Haghpanah, S., Azarkeivan, A., Kattamis, C., Ladis, V., Kilinc, Y., Daar, S., Alyaarubi, S., Yasseen, D., Yassin, M. A., Soliman, A. T., Canatan, D., Obiedat, M., Remawi, H., Mariannis, D., Christodoulides, C., Christou, S., Tzoulis Tags: 112. Thalassemia and Globin Gene Regulation: Poster II Source Type: research