Menopausal hormone therapy and cardiovascular risk. Where are we now?

Menopausal hormone therapy and cardiovascular risk. Where are we now? Curr Vasc Pharmacol. 2018 Jul 08;: Authors: Anagnostis P, Paschou SA, Katsiki N, Krikidis D, Lambrinoudaki I, Goulis DG Abstract Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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, Fortuna A Abstract Direct oral anticoagulants (DOACs) are first-line drugs used for the treatment of venous thromboembolism and prevention of stroke in patients with atrial fibrillation. These drugs do not require the regular biochemical monitoring that is mandatory for warfarin, and they exhibit shorter half-lives and have a faster onset of action. Since recent real-world studies evidence a higher prevalence of adverse side effects than what was anticipated in clinical trials, monitoring the plasma concentrations of DOACs is being used to personalize their pharmacotherapy, in accordance to the characteristics o...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Cancer cell detection in liquid biopsies has been a widely studied application in many microfluidic devices. The use of a common antibody, such as the epithelial cell adhesion molecule (Anti-EpCAM) or other specific antibodies, has facilitated the detection and study of many cancers. However, the use of such antibodies requires a priori knowledge of the cancer source, and many cancer subtypes are missed in screening applications. There remains a need to study a wider range of cancers that maintain the streamlined antibody approach in cell affinity separations. The Human transferrin receptor (CD71) has rec...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract The detection and quantification of microRNA (miRNA) plays essential roles in clinical and biomedical research. Yet, it is of major challenge to sense miRNA with high degree of selectivity and sensitivity due to its unique characteristics of short length, similarity of sequence among family members and low abundance. Here, with the design of a new hairpin/DNA ring ternary probe, we describe the development of a rolling circle amplification (RCA) method for sensitively and selectively sensing miRNA from cancer cells. The target miRNA binds the hairpin/DNA ring probes through toehold-mediated strand displac...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Lab Chip, 2019, Accepted Manuscript DOI: 10.1039/C9LC00469F, PaperTanmay Mathur, Kanwar Abhay Singh, Navaneeth Krishna Rajeeva Pandian, Shu-Huai Tsai, Travis W. Hein, Akhilesh K Gaharwar, Jonathan M. Flanagan, Abhishek Jain Therapeutic approaches to treat vascular dysfunction and thrombosis at disease- and patient-specific levels is an exciting proposed direction in biomedical research. However, this cannot be achieved with animal preclinical models... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN00795D, PaperLi Liu, Rui-Jie Lv, Jong-Kai Leung, Qian Zou, Yue Wang, Fei Li, Wang Liang, Shun Feng, Ming-Yu Wu Cancer is a global health issue and leading cause of death. Discrimination of cancer cells from normal cells is of significant importance for the early diagnosis of cancers. As one... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Recent clinical trials have put immunotherapy front and center for initial treatment decisions in advanced lung cancer.Journal of Clinical Oncology
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Hematology-Oncology Journal Article Source Type: news
Publication date: Available online 18 June 2019Source: Preventive MedicineAuthor(s): Benjamin D. Hallowell, Meheret Endeshaw, Matthew T. McKenna, Virginia Senkomago, Hilda Razzaghi, Mona SaraiyaAbstractFrom 1970 to 2010 the foreign-born population in the United States has rapidly increased from 9.6 to 40.0 million individuals. Historically, differences in cancer rates have been observed between US-born and foreign-born individuals. However, comprehensive and up-to-date data on US cancer rates by birth place is lacking. To compare cancer mortality rates among foreign and US-born individuals, population-based cancer mortalit...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Suh YJ, Park JH, Bilegsaikhan SE, Lee DJ Abstract Prediction of malignant behavior of pheochromocytoma (PC) or paraganglioma (PG) is of limited value. The Cancer Genome Atlas (TCGA) and the French 'Cortico et Médullosurrénale: les Tumeurs Endocrines' (COMETE) network in Paris (France) facilitate accurate differentiation of malignant PC/PG based on genetic information. Therefore, the objective of this transcriptome analysis is to identify the prognostic genes underlying the differentiation of malignant PC/PG in the TCGA and COMETE databases. TCGA carries data pertaining to multigenomic analysi...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Publication date: Available online 17 June 2019Source: European Journal of Surgical OncologyAuthor(s): Robin Detering, Eleonora G. Karthaus, Wernard A.A. Borstlap, Corrie A.M. Marijnen, Cornelis J.H. van de Velde, Willem A. Bemelman, Geerard L. Beets, Pieter J. Tanis, Arend G.J. Aalbers, A.G.J. Aalbers, Y. Acherman, G.D. Algie, B. Alting von Geusau, F. Amelung, T.S. Aukema, I.S. Bakker, S.A. Bartels, S. Basha, A.J.N.M. Bastiaansen, E. BelgersAbstractIntroductionOptimized treatment of primary rectal cancer might have influenced treatment characteristics and outcome of locally recurrent rectal cancer (LRRC). Subgroup analysi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
For NSG residency applications, does it help to have research outside of neurosurgery field (publications in neurology or psychiatry journals)? Or, does it have to be on neurosurgery research? Also, what about basic neuroscience research that is not directly relevant to neurosurgery and is more relevant to psychiatric field (for example, circuits governing thirst/hunger/depression/anxiety/etc)? Would these help as well? Thank you.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Neurosurgery Source Type: forums
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