Primary central nervous system lymphoma in a patient with systemic lupus erythematosus mimicking high-grade glioma: A case report and review of literature

We reported a 39-year-old woman with systemic lupus erythematosus (SLE) developed PCNSL after 15-year treatment with multiple immunosuppressants. Diagnoses: Cranial magnetic resonance imaging (MRI) showed multi-focal lesions with ring-like enhancement post-contrast in the right hemisphere, which mimicked glioma radiographically. Owing to the severe symptoms of intracranial hypertension, gross tumor resection was performed. Pathological exam showed perivascular infiltration of atypical lymphoid cells with CD20 and Epstein-Barr virus (EBV) -encoded RNA (EREB) positive. The patient was diagnosed with diffuse large B-cell lymphoma (DLBCL). Interventions: The patient received six cycles of chemotherapy and autologous stem cell transplantation (ASCT) subsequently. Outcomes: The patient remained complete remission until this article was written. Lessons: PCNSL in immunocompromised hosts may present heterogeneous contrast enhancement, which should be differentiated from other diseases especially high-grade glioma.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

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Conclusions3D printed stem cells seem to have extensive applications in regenerative medicine for the treatment of various diseases. These cells help seed decellularisation of complete organs for regenerative medicine. This technology also applies to the reconstruction of heart valves and has excellent potential in valvular disease. These cells have higher capabilities to fulfil different medical requirements, but it is challenging to steer its growth as per the need of human kind. Scientists created 3D printed stem cells structure which can grow, and they have performed tissue regeneration experiments on them. Traditional...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 17 February 2020Source: The Egyptian RheumatologistAuthor(s): Rehab A. Sallam, Amany S. ElbahnasawyAbstractAim of the workTo assess health-related quality of life (HRQoL) and associated variables in Egyptian ankylosing spondylitis (AS) patients.Patients and methods50 male patients with AS and 50 age-matched controls were enrolled. Clinical and laboratory data were examined including history for peripheral arthritis. Visual analog scale (VAS), Bath AS disease activity index (BASDAI), AS disease activity score (ASDAS)-C-reactive protein (CRP) and ASDAS-erythrocyte sedimentation rate (ESR), ...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
AbstractBakker et al found a change in the magnetic resonance imaging (MRI) findings in 29 of 188 patients, when the examination was repeated at three months and at one year (1). The patients were all being investigated on account of back pain, with presumably varying degrees of concern about the possibility of inflammatory spondyloarthritis.Twelve (6.8%) patients were negative at the initial examination but became positive on subsequent testing. A percentage that was lower, but not dissimilar to Van Onna et al's report of 15% at two years (2).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
Publication date: Available online 17 February 2020Source: NeuroImage: ClinicalAuthor(s): Stefan Frässle, Andre F. Marquand, Lianne Schmaal, Richard Dinga, Dick J. Veltman, Nic J.A. van der Wee, Marie-José van Tol, Dario Schöbi, Brenda W.J.H. Penninx, Klaas E. StephanABSTRACTPatients with major depressive disorder (MDD) show heterogeneous treatment response and highly variable clinical trajectories: while some patients experience swift recovery, others show relapsing-remitting or chronic courses. Predicting individual clinical trajectories at an early stage is a key challenge for psychiatry and might facil...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusion: Congenital unilateral facial palsy caused by a developmental defect outside the context of a syndrome is rare. A multidisciplinary approach is recommended to differentiate between various causes and to initiate timely treatment.What is Known:• Congenital facial palsy is mostly caused by environmental/external fcators.• However in rare cases it can be developmental defect.What is New:• This paper describes 6 cases of isolated congenital facial palsy related to a developmental defect and presents the largest case series in the literature caused by aplasia/hypoplasia of the facial nerve.• MRI a...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusions3-dimensional printing technique-assisted arthroscopic bone graft and fixation of scaphoid nonunion constitute an effective and accurate clinical treatment option.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
We report a case of prenatal diagnosis of an isolated unilateral retrobulbar lymphatic malformation with fetal magnetic resonance imaging (MRI). This was first detected at 27 weeks' gestational age. Postnatal ocular examinations at 4 days and 5 weeks of age showed no signs of optic nerve compromise. Postnatal MRI at 18 days of age showed slight increase in size of the lesion, and no intracranial vascular malformations were detected.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Less than one year after Ipsen SA made its largest-ever acquisition, the company has written down most of the deal ’s value as a loss.  Ipsen spent $1 billion last year to acquire Canadian startup Clementia Pharmaceuticals Inc. and its leading rare disease drug candidate. But the drug giant, which is based in France and has its U.S. headquarters in Cambridge, recorded a $725 million impairment loss on the de al in its year-end financial report, resulting in a $54 million net loss for Ipsen.  The…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionAseptic meningitis may be an atypical phenotype of NMOSD flare that is easily confused with specific infection. Comprehensive evaluation to exclude an infective etiology and enable accurate diagnosis and timely immunotherapy are critical to prognosis.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
UCLA researchers have found that it is possible to assess a person ’s ability to feel empathy by studying their brain activity while they are resting rather than while they are engaged in specific tasks.  Traditionally, empathy is assessed through the use of questionnaires and psychological assessments. The findings of this study offer an alternative to people who may have difficulty filling out questionnaires, such as people with severe mental illness or autism, said senior author Dr. Marco Iacoboni, professor of psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA.“Assessi...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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