Autism Spectrum disorder classification, diagnosis and therapy

Publication date: Available online 12 May 2018 Source:Pharmacology & Therapeutics Author(s): Samata R. Sharma, Xenia Gonda, Frank I. Tarazi Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD. Several scales such as the Childhood Autism Rating Scale (CARS), The Autism Spectrum Disorder–Observation for Children (ASD-OC), The Developmental, Dimensional, and Diagnostic Interview (3di), are available to aid in better assessing the behaviors and symptoms associated with ASD. Nearly 75% of ASD patients suffer from comorbid psychiatric illnesses or conditions, which may include attention-deficit hyperactivity disorder (ADHD), anxiety, bipolar disorder, depression, Tourette syndrome, and others. Both pharmacological and non-pharmacological interventions are available for ASD. Pharmacological treatments include psychostimulants, atypical antipsychotics, antidepressants, and alpha-2 ad...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research

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Conclusions: A critical examination of the results of each study suggests that NA helps to identify, in an innovative way, important aspects of psychopathology like the centrality of the symptoms in a given disorder as well as the mutual dynamics among symptoms. Yet, despite these promising results, the clinical utility of NA is still uncertain as there are important limitations on the analytic procedures (e.g., reliability of indices), the type of data included (e.g., typically restricted to secondary analysis of already published data), and ultimately, the psychometric and clinical validity of the results.Psychother Psychosom
Source: Psychotherapy and Psychosomatics - Category: Psychiatry & Psychology Source Type: research
Psychother Psychosom
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Amphetamines are associated with a higher psychosis risk than methylphenidate in young patients who take these agents to treat attention deficit hyperactivity disorder.Medscape Medical News
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AbstractObjectiveTo identify independent risk factors to develop a central line- associated bloodstream infection (CLABSI) in critically ill neonates with major underlying diseases.MethodsA nested case-control study was conducted in a neonatal intensive care unit (NICU). Patients with a central venous catheter (CVC) were included. Cases were neonates who developed a CLABSI and controls were patients without CLABSI. Variables included: perinatal history, characteristics of the catheter, installation and catheter use, surgical interventions, and hospital stay. Odds ratio (OR) and 95% confidence intervals (CI) were calculated...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusions: The results indicated that probiotic food and supplement withLactobacillus andBifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals withMetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.Ann Nutr Metab 2019;74:224 –241
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Conclusions: BMI and WC may predict incident hypertension better than skinfold thickness, WHR, and WHTR in the Chinese population.Ann Nutr Metab 2019;74:215 –223
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
BEST supplements for cholesterol: Having high cholesterol can pose a huge risk to a person ’s health, so what can you do to lower it? Eating an unhealthy diet is one of the main causes of the condition, but some research has shown certain vitamins, minerals and natural substances can lower high cholesterol levels.
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Post-stroke depression has been previously associated with poorer recovery, but new research suggests depression may also be a risk factor for stroke.Medscape Medical News
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Publication date: Available online 12 May 2018Source: Pharmacology &TherapeuticsAuthor(s): Samata R. Sharma, Xenia Gonda, Frank I. TaraziAbstractAutism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Heredita...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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