The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

Publication date: May 2018 Source:Neurochemistry International, Volume 115 Author(s): Zhihui Zhu, Georg Reiser Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of neurodegenerative diseases, including Parkinson's, Alzheimer's, Alexander's disease, multiple sclerosis, and human immunodeficiency virus-associated dementia. Specifically, sHsps interact with misfolding and damaging protein aggregates, like Glial fibrillary acidic protein in AxD, β-amyloid peptides aggregates in Alzheimer's disease, Superoxide dismutase 1 in Amyotrophic lateral sclerosis and cytosine-adenine-guanine/polyglutamine (CAG/PolyQ) in Huntington's disease, Spinocerebellar ataxia type 3, Spinal-bulbar muscular atrophy, to reduce the toxicity or increase the clearance of these protein aggregates. The degree of HspB4 expression in brain is still debated. For neuroprotective mechanisms, sHsps attenuate mitochondrial dysfunctions, reduce accumulation of misfolded proteins, block oxidative/nitrosative stress, and minimize neuronal apoptosis and neuroinflammation, which are molecular mechanisms commonly accepted to mirror the progression and development of neurodegenerative diseases. The increasing incidence of the neurodegenerative diseases enhance...
Source: Neurochemistry International - Category: Neuroscience Source Type: research

Related Links:

CONCLUSION: Apathy, but not depression, was significantly associated with worse function, with the strongest effects in mild dementia. Results emphasize the need for separate assessments of apathy and depression in the evaluation and treatment of patients with dementia. Understanding their independent effects on function will help identify patients who may benefit from more targeted management strategies. PMID: 30655032 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
CONCLUSIONS: Giving the beneficial effects of outdoor sports and -physical activities, promotion strategies should be strongly advocated and developed nationally and globally. Likewise, dedicated research areas should inspire guidelines for the promotion of various outdoor activities - a good practice for the social scenario and the healthcare system. PMID: 30650943 [PubMed - as supplied by publisher]
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
DEMENTIA is on the rise as more and more people are diagnosed with the disease each year. There is no cure, but some simple lifestyle interventions could help prevent the onset of cognitive decline and dementia. One doctor provides his five expert tips to keep the brain disease at bay.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
(MedPage Today) -- This week's topics include treatment of multiple sclerosis, malaria treatment, overprescription of antibiotics, and fecal transplant for ulcerative colitis.
Source: MedPage Today Public Health - Category: American Health Source Type: news
Conclusion Six months of exercise provided benefits to cognition and mobility in adults with multiple sclerosis. This trial was registered prospectively with the Brazilian Clinical Trials Register, ID: RBR-9gh4km ( To Claim CME Credits Complete the self-assessment activity and evaluation online at CME Objectives Upon completion of this article, the reader should be able to: (1) Recognize the physical and cognitive decline in multiple sclerosis; (2) Identify the importance of exercise on cognition and mobility in patients with mu...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles: CME Article . 2019 Series . Number 2 Source Type: research
Authors: Mumic de Melo L, Hotta Ansai J, Giusti Rossi P, Carvalho Vale FA, Cristhine de Medeiros Takahashi A, Pires de Andrade L Abstract In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among...
Source: Journal of Motor Behavior - Category: Neurology Tags: J Mot Behav Source Type: research
Authors: Arese V, Murabito P, Ribero S, Panzone M, Tonella L, Fierro MT, Papini M, Quaglino P Abstract Autoimmune connective tissue-diseases are more frequent in women and deserve a multidisciplinary approach in which the dermatologist play a major role together with other physicians. Pregnancy in these patients has to be considered a high-risk situation, because of possible worsening of the mother's disease and increased morbility and mortality for the fetus; also, therapies have to be chosen carefully because some drugs cannot be used during pregnancy. For all these reasons, the decision to become pregnant needs ...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Patients with advancing illness have one or more serious conditions (like cancer, congestive heart failure, or dementia, for example) and are experiencing symptoms that impact their quality of life and activities of daily living. In addition, they may be having side effects from treatments, problems eating, frequent emergency department visits, or hospitals readmissions. They may be in an end-of-life stage and could be receiving palliative or hospice care. They rely heavily on paid and unpaid caregivers.        
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Authors: Source Type: research
DEMENTIA is on the rise as more and more people are diagnosed with the disease each year. There is no cure, but some simple lifestyle interventions could help prevent the onset of cognitive decline and dementia. One expert provides five tips to keep the brain disease at bay.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Choosing an individual or a company to come into our home, or that of a vulnerable loved one, to provide assistance with anything from cleaning to personal services is never easy. We are giving an unknown person access to not only our property but to the safety of our loved one who may need care while we are not able to supervise. Choosing the right person or company should be done methodically, and education can help you ask the right questions. View slideshow on HealthCentral about what questions you should ask before hiring an in-home care agency: MedicareFAQ – Medicare Resource Center Support a caregiver or jump...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
More News: ALS | Alzheimer's | Ataxia | Autoimmune Disease | Brain | Dementia | Huntington's Disease | Mitochondrial Disease | Multiple Sclerosis | Neurology | Neuroscience | Parkinson's Disease | Pathology | Toxicology