Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen Background The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. Methods We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus). Eligible participants were aged 18–35 years in VRC19 and 18–50 years in VRC 320. Participants were randomly assigned 1:1 by a computer-generated randomisation schedule prepared by the study statistician. All participants received intramuscular injection of 4 mg vaccine. In VRC 319 pa...
Source: The Lancet - Category: General Medicine Source Type: research

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Publication date: Available online 12 December 2018Source: Journal of the American College of RadiologyAuthor(s): Felix M. Gonzalez, J. Matthew Kerchberger, Douglas D. Robertson, Yara Younan, Adam Singer, Walter A. Carpenter, Richard Duszak, James R. Roberson, Monica B. UmpierrezAbstractPurposeTo evaluate the appropriateness of MRI ordering practices and their effect on clinical management for nontraumatic knee pain at the primary care clinics of a large public urban hospital.Materials and MethodsIn all, 196 consecutive MRIs for nontraumatic knee pain ordered from primary care clinics in a large public urban hospital over ...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Publication date: Available online 12 December 2018Source: Social Science &MedicineAuthor(s): Koryu Sato, Kasisomayajula Viswanath, Hana Hayashi, Yoshiki Ishikawa, Katsunori Kondo, Kokoro Shirai, Naoki Kondo, Keisuke Nakagawa, Ichiro KawachiAbstractHealth communication inequality is one of the potential mechanisms linking socioeconomic status (SES) to health disparities. To our knowledge, no previous study has examined the association between exposure to health information and mortality. We analyzed 3-year follow-up cohort data from the Japan Gerontological Evaluation Study (JAGES), involving 8544 males and 9698 female...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 12 December 2018Source: Social Science &MedicineAuthor(s): Amelia M. Jamison, Sandra Crouse Quinn, Vicki S. FreimuthAbstractVaccine confidence depends on trust in vaccines as products and trust in the system that produces them. In the US, this system consists of a complex network connecting pharmaceutical companies, government agencies, and the healthcare system. We explore narratives from White and African American adults describing their trust in these institutions, with a focus on influenza vaccine. Our data were collected between 2012 and 2014 as part of a mixed-methods investigat...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
We thank the authors for the comments related to this article. We appreciate their comments and suggestions and agree that these studies can be challenging but can also move patient care forward. Obtaining accurate pain scores can be highly subjective and relies on patients reporting pain at a single point in time and a nurse recording the pain score accurately.7 Although pain is subjective, our ability to enter and access the data is much less subjective. In our institution, we have a highly integrated electronic medical records system through EPIC Enterprises (Verona, WI, USA).
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Conclusions: Adolescent patients with genotype 4 chronic HCV infection achieved a good response rate with good ontreatment tolerability for ledipasvir/sofosbuvir therapy.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Background: Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants and children with meningitis and encephalitis in the United States are lacking. Methods: Children 0–17 years of age with meningitis or encephalitis as assessed by International Classification of Diseases, Ninth Revision, codes available in the Premier Healthcare Database during 2011–2014 were analyzed. Results: Six thousand six hundred sixty-five patients with meningitis or encephalitis were identified; 3030 (45.5%) were younger than 1 year of age, 295 (4.4%) were 1–2 years of age, 1460 ...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Between 2000 and 2012, the national estimated incidence rate of pediatric mastoiditis, a rare but serious complication of acute otitis media, was highest in 2006 (2.7/100,000 population) and lowest in 2012 (1.8/100,000 population). This measure provides a baseline for public health surveillance in the pneumococcal conjugate vaccine era as stewardship efforts target antibiotic use in acute otitis media.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
Conclusions: This is the largest cohort of HPeV3 cases with clinical data and pediatrician-assessed neurodevelopmental follow-up to date. Developmental concerns were identified in 11 children at early follow-up. Abnormal magnetic resonance imaging during acute infection did not specifically predict poor neurodevelopmental in short-term follow-up. Continued follow-up of infants and further imaging correlation is needed to explore predictors of long-term morbidity.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
M árcio Bezerra-Santos, Marise do Vale-Simon, Aline Silva Barreto, Rodrigo Anselmo Cazzaniga, Daniela Teles de Oliveira, Mônica Rueda Barrios, Alex Ricardo Ferreira, Nanci C. Santos-Bio, Steven G. Reed, Roque Pacheco de Almeida, Cristiane Bani Corrêa, Malcolm S. Duthie, Amélia Ribeiro de Jesus
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Pattraporn Satitsuksanoa, Kirstin Jansen, Anna G łobińska, Willem van de Veen, Mübeccel Akdis
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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