Looking under the hood: How brain science informs addiction treatment

As a neuroscientist I have been trained to think in a certain way, almost like a car mechanic, who “looks under the hood” at the brains of laboratory rats exposed to drugs. If we can figure out exactly which genes, proteins, brain regions, and neural connections go awry in substance use disorders (SUDs), we can fix those “broken” parts in the brain and design better long-term approaches to addiction treatment. While there is great promise in this approach, it’s not so easy to get under the hood of people who desperately need help with a SUD. It’s very different from working with lab rats. And it can take a long time — often decades — between discovering a way to redirect the addicted brain and an approved treatment. Neuroscientists and practicing clinicians need to be partners in advancing treatment for SUDs Obviously medical and mental health clinicians treat SUDs from the perspective of patient care. They are presented with real people who have very real, very immediate needs. These individuals have often lost their families, their jobs, and their basic health. Their lives may be in jeopardy because of the risk of overdose. The goal is to first detoxify the patientsork with them, through initial recovery from the crisis and beyond, to prevent relapse. This is critically important work, but so is searching for potentially permanent solutions to SUDs. And the place to start is the brain. Over the past 30-plus years, basic labora...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Behavioral Health Brain and cognitive health substance use disorders (SUDs) Source Type: blogs

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ConclusionsWe reveal a novel role for the stress hormone cortisol in modulating the transport of opioids across the BBB, which could contribute to their abuse or overdose. Our updated BBB model represents a powerful tool available to researchers, clinicians, and drug manufacturers for understanding the mechanisms by which opioids access the CNS.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
Purpose of review The aim of this review is to provide an update on recent trends of New Psychoactive Substances (NPS) and the current global strategies implemented to manage them. Recent findings The number of NPS has increased from 166 in 2009 to 892 in 2018, with about 36% having stimulant effects. Such trend revels some unprecedented patterns. The decline in the emergence of new synthetic cannabinoids has coincided with rising deaths due to overdose of fentanyl and non-fentanyl compounds in North America and Europe. The detection of new stimulant NPS has stabilized since 2015. Although the level of seizures of mep...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: ADDICTIVE DISORDERS: Edited by John B. Saunders and Linda B. Cottler Source Type: research
I had an idyllic childhood. I was a cheery kid with great parents, raised in a wonderful neighborhood, always cared for and never wanted for anything. When people hear this background from someone whose addiction was so strong that they planned their methamphetamine use around their pregnancy, it can be hard to reconcile. There is no blueprint for addiction; this disease has no face. Not one person in my life would have guessed I’d be homeless with multiple DUIs, totaled a number of vehicles, and would have my son taken away by authorities twice before his second birthday, but it happened. And despite how absurd it m...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Parenting Substance Abuse Addiction Recovery custody Methamphetamines Motherhood Source Type: news
Fewer than 20 percent of people with private healthcare insurance who suffered a non-fatal opioid overdose ultimately receive abuse or addiction treatment, according to a study published Wednesday by JAMA Network Open.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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Source: Journal of Addictive Diseases - Category: Addiction Authors: Source Type: research
During this coronavirus pandemic, there are many risks posed to people who have an addiction....The postDangers of Overdosing During Coronavirus Quarantine appeared first onCliffside Malibu.
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery addiction treatment aftercare coronavirus covid-19 covid19 drug overdose Source Type: blogs
We describe the historical use of opioids and the scope of the current opioid crisis, review the differences between dependence and addiction, and the private and public sectors response to pain management and highlight the issue of adolescent vulnerability. We conclude with a proposal for future directions that address both public and patient health needs.
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Jorge A. Gálvez Source Type: research
Conclusions A 6-month opioid educational intervention did not reduce opioid adverse events or alter opioid use in hospitalized patients. The authors ’ findings suggest that despite opioid and multimodal analgesia awareness, limited-duration educational interventions do not substantially change the hospital use of opioid analgesics.Editor ’s PerspectiveWhat We Already Know about This TopicEducation may promote safer opioid use in hospitalsWhat This Article Tells Us That Is NewThe investigators conducted a difference-in-differences analysis before and after implementation of opioid training in 31 intervention hos...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
The diagnosis of opioid use disorder (OUD) is often overlooked or inadequately managed during the inpatient admission. When recognized, a common strategy is opioid detoxification, an approach that is often ineffective and can be potentially dangerous because of loss of tolerance and subsequent risk for overdose. Medication for addiction treatment (MAT), including methadone and buprenorphine, is effective and can be dispensed in the hospital for both opioid withdrawal and initiation of maintenance treatment. Hospitalists should be knowledgeable about diagnosing and managing patients with OUD, including how to manage acute p...
Source: Medical Clinics of North America - Category: Primary Care Authors: Source Type: research
This study collects different types of iboga-derived samples from treatment providers, vendors and online buyers to analyse their content. Methods Analysis of iboga products (n = 16) was performed using gas chromatography and mass spectrometry methods (GC/MS). Products included Iboga root bark, Total Alkaloids (TA), Purified Total Alkaloids (PTA HCl), ibogaine hydrochloride (ibogaine HCl) and one Voacanga africana root bark. Results The content of ibogaine was highly variable, ranging from 0.6% to 11.2% for products sold as iboga root bark, from 8.2% to 32.9% for products sold as TA, 73.7% for one sample sold as PTA and fr...
Source: Revista de Psiquiatria Clinica - Category: Psychiatry Source Type: research
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