Antibiotic use linked to 'pre-cancerous' bowel changes
Conclusion Antibiotics, like all drugs, have side effects. We know that they affect the composition of bacteria that live in a healthy gut. This study suggests that might possibly be linked to future development of bowel cancer. However, there are some major limitations to keep in mind. Bowel polyps are very common, and they're not cancerous. Most people who have them won't know they're there, unless they have a colonoscopy. Some polyps do develop into bowel cancer, but we don't know if any of these women got bowel cancer, or how many of their polyps would have become cancerous if not treated. It's highly possible that women aged 60 might not remember accurately how often they used antibiotics in their 20s, or for how long. So we can't be sure whether women were over-estimating or under-estimating their antibiotics use. Observational studies such as this cannot show that one factor directly causes another. As the researchers say, antibiotics are used to treat bacterial infections. Infections cause inflammation, and that's a risk factor for cancer. So the study may have measured the effect of repeated exposure to bacterial infection, rather than use of antibiotics. The study was only carried out in women, so we don't know if the results apply to men. The study did a good job of controlling for other potential confounding risk factors, but no study can control for everything. It's possible there are other factors involved which we don't know about. Antibiotics have been over-us...
A study of more than 90,000 British adults by the University of East Anglia also found that gay men are 28 per cent less likely to be overweight or obese than their straight counterparts.
It is certainly no secret that nutrition in the first few years of life, when growth is rapid, plays a major role in long-term health outcomes in regard to both optimal growth and obesity prevention. Formula fed infants gain weight faster than breastfed infants and weight gain is greater in formula fed infants receiving isocaloric formulas with higher protein content. Although the evidence favors promoting breast milk over formula feedings, there is little evidence-based guidance as to which complementary feeds should be given to promote optimal growth and to prevent obesity.
Geserick M, Vogel M, Gausche R, Lipek T, Spielau U, Keller E, et al. Acceleration of BMI in Early Childhood and Risk of Sustained Obesity. N Engl J Med 2018;379:1303-12.
Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med 2018;378:2275-87.
Conclusions: AWG immediately after PSWG, even occurring at only 1 of 3 interval from 3 –4 to 6–9 months, from 6–9 to 17–20 months, and 17–20 months to 3 years after PSWG, leads to an overweight status at 3 years of age. Monitoring weight growth after PSWG may help identify AWG and later overweight risk.Ann Nutr Metab 2019;74:181 –188
LUNG cancer symptoms include a cough the won ’t go away, unexplained weight loss and severe chest pain. But you could also be at risk of deadly lung tumour signs if your eyes are a distinctive colour.
While medicine transforms cancer into a chronic disease with which patients can live for an extended period of time, financial toxicity threatens to turn chronic, too.
This study examined the risk for postoperative complications, reoperations, and readmissions for patients with insulin-dependent diabetes mellitus (IDDM), patients with non-insulin-dependent diabetes mellitus (NIDDM), and patients without diabetes undergoing total joint replacements (TJRs). The American College of Surgeons National Surgical Quality Improvement Program database was queried for all primary TJRs in 2015. The study identified 78,744 TJRs (84.1% nondiabetic patients, 12.0% NIDDM, and 3.9% IDDM). Multiple logistic regression models identified IDDM as an independent risk factor for increased blood loss, myocardia...
This study sought to characterize the changes in general immunity occurring during the progression from pre-diabetes to T2D. Male rats were fed a high-fat high-carbohydrate diet for 20 weeks (pre-diabetes induction period) and kept on the same diet being monitored for a further 12 weeks (experimental period). Blood was collected for haemocytometer analysis on week 0, 4, 8, and 12 of the experimental period after which the animals were sacrificed. Plasma was collected from centrifuged blood for ELISA (TNF-α, CRP, P-selectin, CD40 L, fibrinogen, and IL-6). Blood neutrophils percentage significantly...
Elisa Boldrin, Sandro Malacrida, Enrica Rumiato, Giorgio Battaglia, Alberto Ruol, Alberto Amadori, Daniela Saggioro
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