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Antibiotic use linked to 'pre-cancerous' bowel changes

Conclusion Antibiotics, like all drugs, have side effects. We know that they affect the composition of bacteria that live in a healthy gut. This study suggests that might possibly be linked to future development of bowel cancer. However, there are some major limitations to keep in mind. Bowel polyps are very common, and they're not cancerous. Most people who have them won't know they're there, unless they have a colonoscopy. Some polyps do develop into bowel cancer, but we don't know if any of these women got bowel cancer, or how many of their polyps would have become cancerous if not treated. It's highly possible that women aged 60 might not remember accurately how often they used antibiotics in their 20s, or for how long. So we can't be sure whether women were over-estimating or under-estimating their antibiotics use. Observational studies such as this cannot show that one factor directly causes another. As the researchers say, antibiotics are used to treat bacterial infections. Infections cause inflammation, and that's a risk factor for cancer. So the study may have measured the effect of repeated exposure to bacterial infection, rather than use of antibiotics. The study was only carried out in women, so we don't know if the results apply to men. The study did a good job of controlling for other potential confounding risk factors, but no study can control for everything. It's possible there are other factors involved which we don't know about. Antibiotics have been over-us...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medication Source Type: news

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Effect of polyvalent immunoglobulins on the cytokine cascade in monocytes from colorectal cancer patients: Basis for a new adjuvant therapy
. Int J Clin Pharmacol Ther. 2017 Dec 12;: Authors: Gasser M, Lissner R, Waaga-Gasser AM PMID: 29231166 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
CONCLUSION: The results suggest that the combination of lapatinib plus capecitabine can improve PFS and OS in patients with HER2-positive breast cancer that has progressed on trastuzumab. However, it appears that trastuzumab emtansine provides better treatment outcomes in this context.
. PMID: 29231164 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Linda van Eikenhorst, Katja Taxis, Liset van Dijk, Han de Gier
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: The overall melanoma detection rate in our free Skin Cancer Screening Program is comparable to those in European public activities. The costs of free screening programs compare favorably with the prevented potential therapeutic costs of late-stage melanoma. The low response rate of screenees agreeing to be followed up limits conclusions of this study.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
This study aimed to assess the effects of ZST93 on cell proliferation and its role in the chemosensitivity to gemcitabine in human pancreatic cancer cells. The effects of ZST93 on cancer cell proliferation, cell cycle distribution, apoptosis and autophagy were evaluated in various human pancreatic cancer cell lines, and the anti‐tumor effects of ZST93 alone and in combination with gemcitabine were identified in a xenograft mouse model. The results showed that ZST93 could inhibit the proliferation of pancreatic cancer cells and arrest cell cycle at G0/G1 phase by regulating the expression of Cyclin D1 and Cyclin A2. Moreo...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Date: Tuesday, 04 03, 2018; Speaker: Paul Bieniasz, Rockefeller University; Gordon Carmichael, University of Connecticut; Mariano Garcia-Blanco, University of Texas; Eva Gottwein, Northwestern University; Wei-Shau Hu, National Cancer Institute; Jianming Hu, Pennsylvania State University; Rozanne Sandri-Goldin, University of California, Irvine; Building: Building 45 (Natcher Building); E1/E2
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Monday, 04 09, 2018; Speaker: Bruno Amati, European Institute of Oncology; Jay Bradner, Novartis; Michael Cole, Dartmouth College; Chi Van Dang, Ludwig Institute for Cancer Research; Martin Eilers, University of Wurzburg; Robert Eisenman, Fred Hutch Cancer Research Center; Gerard Evan, Cambridge University; Dean Felsher, Stanford University; Carla Grandori, Cure First; Ross Hannon, John Curtin School of Medical Research; Marie Arsenian Henriksson, Karolinska Institutet; Laurence Hurley, University of Arizona; Raghu Kalluri, MD Anderson Cancer Center; Angela Koehler, Massachusetts Institute of Technology; Linda Penn, ...
Source: NIH Calendar of Events - Category: American Health Source Type: events
CANCER symptoms affect men more than women, but spotting them early could help survival rates. Signs of the disease include diarrhoea, weight loss and back pain.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Summary The obesity supine death syndrome refers to a catastrophic cascade of cardiorespiratory complications resulting from the supine positioning of a morbidly obese subject which can ultimately lead to death. It was first described in 1977 in two massively obese patients who were forced to lie down for medical procedures. But surprisingly, despite the current worldwide epidemic of obesity, very few cases have been reported yet. It can be assumed that the syndrome is poorly recognized in clinical practice and may participate in the high rate of unexplained death in morbidly obese patients. Based on the previously publish...
Source: Obesity Reviews - Category: Eating Disorders & Weight Management Authors: Tags: Obesity/Etiology and Pathophysiology Source Type: research
I've lost track of all the questions about my type 1 diabetes that I've answered by turning to the Diabetes Online Community (aka "the DOC").It's been a wellspring of knowledge and wisdom, helping me figure out if I should try new technology, the ...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
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