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Antibiotic use linked to 'pre-cancerous' bowel changes

Conclusion Antibiotics, like all drugs, have side effects. We know that they affect the composition of bacteria that live in a healthy gut. This study suggests that might possibly be linked to future development of bowel cancer. However, there are some major limitations to keep in mind. Bowel polyps are very common, and they're not cancerous. Most people who have them won't know they're there, unless they have a colonoscopy. Some polyps do develop into bowel cancer, but we don't know if any of these women got bowel cancer, or how many of their polyps would have become cancerous if not treated. It's highly possible that women aged 60 might not remember accurately how often they used antibiotics in their 20s, or for how long. So we can't be sure whether women were over-estimating or under-estimating their antibiotics use. Observational studies such as this cannot show that one factor directly causes another. As the researchers say, antibiotics are used to treat bacterial infections. Infections cause inflammation, and that's a risk factor for cancer. So the study may have measured the effect of repeated exposure to bacterial infection, rather than use of antibiotics. The study was only carried out in women, so we don't know if the results apply to men. The study did a good job of controlling for other potential confounding risk factors, but no study can control for everything. It's possible there are other factors involved which we don't know about. Antibiotics have been over-us...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medication Source Type: news

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Authors: Pinkas J, Bojar I, Gujski M, BartosiƄska J, Owoc A, Raczkiewicz D Abstract BACKGROUND Increasing age, increased body mass index (BMI), and abnormal lipid profiles contribute to an increased risk of vitamin D deficiency. Women who have a perimenopausal and postmenopausal reduction in estrogen levels are a high-risk group for vitamin D deficiency. The aims of this study were to compare the serum vitamin D levels, lipid profile, and BMI between perimenopausal and postmenopausal women in non-manual employment, and to determine whether there were any interdependent factors. MATERIAL AND METHODS Three hundred w...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS High-expression of S100A6 was identified as an independent unfavorable prognostic factor for SCC, suggesting that targeting S100A6 may result in the development of potential targeted drug for SCC. PMID: 29053662 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
In this study, we explored in a prospective cohort of morbidly obese women undergoing laparoscopic Roux-en-Y gastric bypass (LRYGP) correlations between baseline anthropometrics, metabolic parameters, resting energy expenditure (REE), body composition, and 1-year % excess body mass index loss (%EBMIL). We also investigated risk factors for insufficient %EBMIL.MethodsOne hundred three consecutive women were prospectively evaluated at baseline (age 40.6  ± 11.2, weight 113.9 kg ± 15.3, BMI 43.3 ± 4.9 kg/m2) and 1  year after LRYGP. Weight, excess weight, brach...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsThe long-term result for weight loss after LAGB is unsatisfactory. The revision of failed LAGB to other bariatric surgeries is safe and can be performed in one stage with a low complication rate. Patients who underwent R-LSAGB had better weight loss results than the R-LSG or R-LRYGB patients.
Source: Obesity Surgery - Category: Surgery Source Type: research
This study aims to assess the safety and durability of single-stage conversion from LAGB to SAGB in patients who are intolerant to LAGB and who also fail to lose weight, or re-gain weight.MethodsSeventy-four patients with BMI> 35 kg m−2 were selected from a prospective bariatric database between July 2012 and December 2015 for revisional laparoscopic SAGB surgery and were followed up at 6  weeks, 3, 6 and 12 months after their operation.ResultsThe mean BMI at 6  weeks, then 3, 6 and 12 months were 41.6 ± 7.66, 38.8 ± 7.54, 35.4 ± ...
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractIntroductionNot long ago, laparoscopic adjustable gastric banding (LAGB) was considered a safe and effective treatment of morbid obesity; however, long-term outcomes revealed significant complication and failure rates. We hypothesized that LAGB has higher rates of weight loss failure, reoperation, and overall failure compared to laparoscopic gastric bypass (LRYGB) at long-term follow-up.MethodsA matched case-control study was performed. Patients who underwent primary LAGB or LRYGB at a university hospital between 2004 and 2011 were propensity matched for age, gender, race, body mass index (BMI), and weight-related ...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsThere is a continued overall trend in the increased popularity of the SG and decreased utilization of the RYGB and LAGB, although growth of the SG appears to be slowing. This is also true among patients with type 2 diabetes mellitus. Regardless of surgery type, underinsured and African-American race were more likely to be readmitted.
Source: Obesity Surgery - Category: Surgery Source Type: research
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