Abstract IA11: Chemoprevention in hereditary GI cancer syndromes

Chemoprevention offers an attractive option to prevent the occurrence of cancer in high risk cancer syndromes, such as familial adenomatous polyposis (FAP) and Lynch syndrome. However, data, especially from clinical trials, is sparse. This presentation will review the state of art concepts of chemoprevention in regards to these hereditary GI cancer syndromes.Lynch Syndrome: In the randomized CAPP2 trial, 861 participants with Lynch syndrome took either daily aspirin (600 mg) or placebo for up to 4 years; the primary endpoint was the development of CRC (1). After a mean follow-up of 55.7 months, participants taking daily aspirin for at least 2 years had a 63% reduction in the incidence of CRC (incidence rate ratio [IRR], 0.37; 95% CI, 0.18–0.78; P = .008). These participants also saw a reduced risk from all Lynch syndrome cancers (IRR, 0.42; 95% CI, 0.25–0.72; P = .001). Risk of colorectal neoplasia was unaffected, and there was no protection seen for participants who completed 50% of patients and duodenal adenocarcinoma occurring in up to 12% (14, 15). Following colectomy, duodenal adenocarcinoma is the leading cause of cancer death in these patients, and prevention of duodenal adenocarcinomas by endoscopic surveillance with polyp resection, duodenectomy, Whipple surgical procedure, and ampullectomy are often challenging and suboptimal (16). NSAIDs have much less efficacy in duodenal adenomas (17, 18). A recent trial involving 92 FAP patients randomized to therapy with du...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Prevention Source Type: research