The physiological/pathophysiological significance of Vitamin D in cancer, cardiovascular disorders and beyond.

The physiological/pathophysiological significance of Vitamin D in cancer, cardiovascular disorders and beyond. Curr Drug Metab. 2016 Dec 07; Authors: AlMatar M, AlMandeal H, Makky EA, Kayar B, Yarar E, Var I, Köksal F Abstract Vitamin D, a molecular precursor of the potent steroid hormone calcitriol, has a crucial functions and roles in physiology and pathophysiology. Tellingly, Calcitriol has been shown to regulate various cellular signalling networks and cascades that have crucial role in cancer biology and diagnostics. Mounting lines of evidences from previous clinical and preclinical investigations indicate that the deficiency of vitamin D may contribute to the carcinogenesis risk. Concomitantly, recent reports suggested that significant reduction in the cancer occurrence and progression is more likely to appear after vitamin D supplementation. Furthermore, a pivotal role functioned by vitamin D in cardiovascular physiology indicates that the deficiency of vitamin D is significantly correlated with enhanced of the prevalence of stroke, hypertension and myocardial infarction. Notably, vitamin D status is more likely to be used as a lifestyle biomarker, since poor and unhealthy lifestyles are correlated with the deficiency of vitamin D, a feature which may result in cardiovascular complications. Moreover, recent reports revealed that the effect of vitamin D to cover not only cardiovascular system but also skeletal system. Of note,...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research