Tmod-27. autopsy derived orthotopic xenograft (adox) mouse models for terminal pediatric brain tumors

In conclusion, we have demonstrated that a fraction of tumor cells can survive the lengthy period of postmortem anoxia/starvation and regain tumorigenic capabilities in mouse brains; and identified CD57 as a new marker of the therapy-resistant cells. This novel panel of ADOX models should facilitate biological studies and preclinical therapy of pediatric brain tumors.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Qi, L., Baxter, P., Kogiso, M., Du, Y., Lindsay, H., Liu, Z., Su, J., Adesina, A., Walter, A., Murray, J., McNall-Knapp, R., Nazarian, J., Will Parsons, D., Chintagumpala, M., Blaney, S., Li, X.-N. Tags: TUMOR MODELS Source Type: research