A Mysterious Neurological Condition Is Paralyzing Children

The U.S. Centers for Disease Control and Prevention is investigating the rise of a rare polio-like illness that tends to strike children. Acute flaccid myelitis, a condition that affects the nervous system, has sickened 89 people across 33 states so far this year, and doctors aren’t sure what causes it.  Scientists still only have a preliminary understanding of how AFM affects children, but it appears to affect muscle tone, sometimes to the point of long-term paralysis.   Symptoms include sudden weakness in the limbs, loss of muscle strength and decreased reflexes. Other signs of the disease include droopy eyes, slurred speech, or difficulty swallowing. In particular, there’s a wide spectrum of muscle weakness, ranging from mild weakness in a single limb to almost complete paralysis in all four limbs, or a loss of the ability to breathe on one’s own. One alarming complication is that AFM appears to be triggered by common viruses, which means that children can start off with fever and respiratory issues that can then develop into muscle weakness and other symptoms associated with AFM. Because of how AFM starts, parents may not get their children to the hospital on time to pinpoint a potential viral cause, said Dr. Kevin Messacar, a pediatric infectious disease physician and researcher at Children’s Hospital Colorado.  While it’s normal to take care of children at home with fluids, rest and relaxation for illnesses that appear t...
Source: Science - The Huffington Post - Category: Science Source Type: news

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CONCLUSION: Patient satisfaction with maxillary IODs on two implants did not change from baseline to 4 years and was high at 4 years of function. PMID: 30883624 [PubMed - in process]
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Unfortunately, the Acknowledgements section was not included in the original version of the article. The said section is given here.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractThe role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome in hospitalized patients with a confirmed influenza virus infection. A retrospective observational study including all adult patients who were hospitalized in our center with a confirmed influenza virus infection from January to May 2016. Viral load was measured by real-time reverse-transcriptase –polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on upper respiratory tract samples. Its value was ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
In this study, we used silkworm pupae to develop a safer vaccine for Alzheimer’s disease (AD) patients. Aβ15 peptide was fused with the cholera toxin B subunit (CTB) and expressed in silkworm pupae. Then, we tested an oral vaccine with the peptide expressed by silkworm pupae in a transgenic mouse model of AD. The results show that anti-Aβ antibodies were induced, Aβ deposition in the brain decreased, the content of malondialdehyde was lower than in the other group, and memory and cognition of the mice improved. These results suggest that the high-nutrient CTB-Aβ15 silkworm pupa vaccine has ...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
In this study, we report the morphology, biochemistry, and molecular characteristics of an A. mycotoxinivorans strain isolated from a pediatric patient with congenital ventricular septal defect and pneumonia. A female patient, 26 months old, presented with congenital ventricular septal defect. Pulmonary infection symptoms were observed after the patient received cardiac repair surgery. Sputum bacterial and fungal cultures were positive for Elizabethkingia anophelis and a fungus, which was not readily identifiable using biochemical identification, or MALDI-TOF MS analysis. The strain was finally identified as A. m...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 18 March 2019Source: BiologicalsAuthor(s): Shuyun Qin, Dmitriy Volokhov, Elvira Rodionova, Christoph Wirblich, Matthias J. Schnell, Vladimir Chizhikov, Alena DabrazhynetskayaAbstractThe Rapid Fluorescent Focus Inhibition Test (RFFIT) is a standard assay used to detect and assess the titers of rabies virus neutralizing antibodies (RVNA) in blood sera. To simplify the multistep RFFIT procedure by eliminating the immunostaining step, we generated a new recombinant RV expressing a green fluorescent protein (rRV-GFP) and assess its suitability for quantifying RVNA. We rescued the rRV-GFP virus...
Source: Biologicals - Category: Biology Source Type: research
Conclusion: LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults. PMID: 30881982 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 18 March 2019Source: The Lancet Global HealthAuthor(s): Vanessa Brizuela, Hannah H Leslie, Jigyasa Sharma, Ana Langer, Özge TunçalpSummaryBackgroundEnsuring quality of care during pregnancy and childbirth is crucial to improving health outcomes and reducing preventable mortality and morbidity among women and their newborns. In this pursuit, WHO developed a framework and standards, defining 31 quality statements and 352 quality measures to assess and improve quality of maternal and newborn care in health-care facilities. We aimed to assess the capacity of globally used, large-s...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Recent years have seen a multiplication of terrorist attacks in public places across European and North American countries, thus heightening the need for public mental health planning and response strategies focused on the special needs of children and the...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 18 March 2019Source: Reumatología Clínica (English Edition)Author(s): Adriana Ivonne Céspedes Cruz, Myriam Méndez Núñez, Eunice Solís Vallejo, Maritza Zeferino Cruz, Alfonso Ragnar Torres Jiménez, Verónica Ocampo Sánchez, Beatriz Flores Meza, Norma Quintana RuizAbstractIntroductionJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterised by the presence of arthritis in children under 16 years of age for more than 6 weeks in the absence of any other known cause.The extra-articular manifestations, ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
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