What PPIs and the Kardashians have in common

The science we conduct often reflects the society we live in. One phenomenon of current society is the rise of the reality television show. Participants are promised instant media fame without having to struggle through acting school. I worry that this has rubbed off on some of the studies we now conduct. Sir Richard Doll and Austin Hill, the architects of modern epidemiology, realized that it was hard for epidemiology to prove or disprove anything. Their studies were driven by clear hypotheses as some took five to 10 years to complete. Furthermore, their landmark paper on smoking and lung cancer devoted over a page of discussion as to why the observed association of an odds ratio greater than 10 of lung cancer in smokers may not be causal. This scientific version of the reality TV show is exemplified by some studies linking proton pump inhibitors (PPIs), commonly prescribed for gastroesophageal reflux disease (GERD), to a variety of diseases. PPIs have been associated with GI infections (including Clostridium difficile), pneumonia, bone fractures, pernicious anemia, interactions with clopidogrel, and heart disease. To this list we can now add chronic kidney disease and dementia. When a drug is associated with a long list of unrelated bad consequences it usually turns out that most, if not all, of these associations are not causal. This phenomenon was noted over 50 years ago but seems to have been forgotten by modern epidemiologists in the pursuit of the quick high-...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions GI Source Type: blogs

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Conclusions: Hyperthermia increased the serum neutrophil-recruiting cytokine levels and reduced the magnitude of chemotherapy-induced neutropenia. Thus, HIPEC improved neutrophil and bone marrow recovery compared with conventional IP chemotherapy. PMID: 31818168 [PubMed - in process]
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Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC08498C, CommunicationPeng Gao, Mingwan Shi, Ruyue Wei, Wei Pan, Xiaohan Liu, Na Li, Bo Tang A homotypic cancer cell membrane camouflaged MOF-based nanoreactor with the photothermal-starvation effect has been developed for synergistic suppression of intracellular defensive systems for enhanced cancer treatment. The content of this RSS Feed (c) The Royal Society of Chemistry
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Authors: Wang J, Zhang Y, Lu X, Xi C, Yu K, Gao R, Bi K Abstract Background: Idiopathic granulomatous mastitis (IGM) can clinically and radiographically mimic an abscess or breast cancer. Although IGM is benign, it can cause the breast skin to appear "riddled with holes" and can even result in the loss of the breast. The optimal treatment has not been established. Methods: We retrospectively studied the medical records of 200 patients with IGM who were treated for skin rupture from June 2015 to June 2017 in our institute. The patients' treatment modalities (including surgery after steroid therapy and ster...
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[This Day] Martins Ifijeh chronicles the life of a young ambitious Nigerian woman who was diagnosed with breast cancer, but due to ignorance and high cost of treatment, opted for herbal treatment in Jos, as against orthodox treatment, which then worsened her condition. She was however lucky to retrace her steps on time, and she is presently accessing proper healthcare in Abuja
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[This Day] Abuja -Over 5,000 persons have benefited from diabetes, hypertension, cervical and breast cancer free screening, which was facilitated by MITEDA Wellness Initiative, a nongovernmental organisation and in collaboration with the Lagos State government.
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Authors: Batra A, Cheung WY Abstract The term "real-world evidence" (rwe) describes the analysis of data that are collected beyond the context of clinical trials. The use and application of rwe have become increasingly common and relevant, especially in oncology, because there is growing recognition that randomized controlled trials (rcts) might not be sufficiently representative of the entire patient population that is affected by cancer, and that specific clinical research questions might be best addressed by real-world data. In this brief review, our main aim is to highlight the role of rwe in informin...
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