Stroke After PCI Linked to Platelet Reactivity on Plavix
(MedPage Today) -- But it's unclear whether link seen in post hoc analysis would be actionable (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 7, 2018 Category: Cardiology Source Type: news

Many Prescriptions for Newer, More Expensive Antiplatelet Agents Go Unfilled Many Prescriptions for Newer, More Expensive Antiplatelet Agents Go Unfilled
Prescriptions for the P2Y12 inhibitors prasugrel hydrochloride and ticagrelor hydrochloride after percutaneous coronary intervention (PCI) are outpacing those for clopidogrel, but many patients are not filling those prescriptions, researchers report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

POINT: Success at Last for Dual Antiplatelet After Stroke, TIA POINT: Success at Last for Dual Antiplatelet After Stroke, TIA
A combination of clopidogrel plus aspirin reduced major ischemic events vs aspirin alone in patients with minor ischemic stroke or high-risk TIA in this long-awaited trial.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 17, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Clopidogrel & #43; Aspirin Cuts Ischemic Events in Stroke, TIA
THURSDAY, May 17, 2018 -- The combination of clopidogrel and aspirin is associated with reduced risk of major ischemic events but increased risk of major hemorrhage among patients with minor ischemic stroke or high-risk transient ischemic attack... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 17, 2018 Category: Pharmaceuticals Source Type: news

International study suggests combination therapy may prevent stroke in certain people
(NIH/National Institute of Neurological Disorders and Stroke) Results from an international clinical trial of more than 4880 participants, published in the New England Journal of Medicine, show that combining clopidogrel and aspirin following a small stroke or experiencing minor stroke symptoms decreases risk of a new stroke, heart attack or other ischemic event within 90 days. The combination therapy was also associated with an increase in major bleeding, although many of those episodes were non-fatal and did not occur in the brain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

After'Mini-Stroke,' Drug Combo (Aspirin Plus Clopidogrel) Could Help Cut Odds for Major Attack
WEDNESDAY, May 16, 2018 -- A dual-drug approach after a " mini-stroke " might maximize a person's odds of avoiding a more major stroke in the months after, research shows. Minor strokes and events known as " transient ischemic attacks " (TIA), or... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 16, 2018 Category: General Medicine Source Type: news

Stroke prevention drug combo shows promise
If you've had a minor stroke or a transient ischemic stroke (TIA), taking the clot-preventing drug clopidogrel along with aspirin may lower your risk of having a major stroke within the next 90 days, according to new research published in The New England Journal of Medicine. (Source: World Pharma News)
Source: World Pharma News - May 16, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Stroke prevention drug combo shows promise, study says
(University of Texas at Austin) If you've had a minor stroke or a transient ischemic stroke (TIA), taking the clot-preventing drug clopidogrel along with aspirin may lower your risk of having a major stroke within the next 90 days, according to new research published in The New England Journal of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2018 Category: International Medicine & Public Health Source Type: news

Routine Genotyping for Clopidogrel Response Sustainable in Practice (CME/CE)
(MedPage Today) -- Group's findings support use, but impact remains unproven in trials (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 3, 2018 Category: Cardiology Source Type: news

AHA: Gene Test Predicts Who Won't Benefit From Blood Thinner Plavix
TUESDAY, April 3, 2018 (American Heart Association) -- Heart stent patients with a certain gene mutation may need to consider alternatives to Plavix, a commonly prescribed blood thinner, a new study suggests. Researchers reported Tuesday that... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 3, 2018 Category: General Medicine Source Type: news

Genetic test may improve post-stent treatment, outcome
(American Heart Association) A test for specific genetic mutations successfully informed blood-thinner treatment selection following stent placement to open clogged blood vessels, leading to significantly fewer complications. Genetic testing identified patients with specific mutations that render the widely used blood thinner clopidogrel ineffective. Patients with the genetic mutations who received alternative medications were much less likely to die or have a heart attack, stroke or other complications than patients with the mutations who received clopidogrel. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 3, 2018 Category: International Medicine & Public Health Source Type: news

Going Generic OK for Clopidogrel
(MedPage Today) -- Non-inferiority achieved for ACS survivors in Canadian study (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 14, 2018 Category: American Health Source Type: news

New Studies Encourage Clopidogrel Genotyping New Studies Encourage Clopidogrel Genotyping
Two new studies suggest genotyping patients with ACS or those undergoing PCI to identify poor clopidogrel responders influences decision making on drug therapy by the interventionalist and may lead to benefits in outcomes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 12, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

TREAT: Ticagrelor Safe in STEMI Patients After Fibrinolysis TREAT: Ticagrelor Safe in STEMI Patients After Fibrinolysis
Randomized but open-label data show ticagrelor was noninferior to clopidogrel in terms of major bleeding at 30 days for patients with ST-segment elevation MI.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 12, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Ticagrelor Can Safely Follow Lytic Tx for STEMI
(MedPage Today) -- Bleeding similar upon delayed adminstration of ticagrelor versus clopidogrel (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 11, 2018 Category: Cardiology Source Type: news

Ticagrelor for Stroke: Encouraging Results in Platelet Study Ticagrelor for Stroke: Encouraging Results in Platelet Study
Ticagrelor was associated with a lower rate of high on-treatment platelet reactivity than clopidogrel in Asian patients who had had a minor stroke or high-risk TIA in the PRINCE trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 23, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Aspirin vs. Plavix
Title: Aspirin vs. PlavixCategory: MedicationsCreated: 2/14/2018 12:00:00 AMLast Editorial Review: 2/14/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 14, 2018 Category: Cardiology Source Type: news

Aspirin vs. Plavix (clopidogrel)
Title: Aspirin vs. Plavix (clopidogrel)Category: MedicationsCreated: 2/14/2018 12:00:00 AMLast Editorial Review: 2/14/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 14, 2018 Category: Cardiology Source Type: news

Acute coronary syndromes -- Did prasugrel & ticagrelor offer same benefits as clopidogrel?
(Bentham Science Publishers) In patients presenting with acute coronary syndromes (ACS) either with or without ST-segment elevation MI (STEMI and NSTEMI), dual antiplatelet therapy (DAPT) is recommended for at least 1 year independently of whether revascularization is performed. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 7, 2018 Category: International Medicine & Public Health Source Type: news

Ibuprofen and Plavix (Side Effects and Interactions)
Title: Ibuprofen and Plavix (Side Effects and Interactions)Category: MedicationsCreated: 2/2/2018 12:00:00 AMLast Editorial Review: 2/2/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 2, 2018 Category: Cardiology Source Type: news

Coumadin vs. Plavix (Differences and Similarities)
Title: Coumadin vs. Plavix (Differences and Similarities)Category: MedicationsCreated: 2/1/2018 12:00:00 AMLast Editorial Review: 2/1/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 1, 2018 Category: Cardiology Source Type: news

Recall of medication for high risk heart attack and stroke patients: Clopidogrel, sold as Plavix, has been mislabeled and recalled
(Natural News) International Laboratories voluntarily recalled a single lot of its clopidogrel tablets largely due to drug mislabeling, a Cardiovascular Business report revealed. According to the report, bottles of 30 tablets contained simvastatin instead of clopidogrel. The company sent out letters to its distributors and customers to alert them of the error. International Laboratories also arranged for a return of... (Source: NaturalNews.com)
Source: NaturalNews.com - January 19, 2018 Category: Consumer Health News Source Type: news

Clopidogrel Tablets Recalled, May Contain Simvastatin Clopidogrel Tablets Recalled, May Contain Simvastatin
International Laboratories issued the recall because the tablets, labeled as clopidogrel 75 mg, may contain the cholesterol-lowering drug simvastatin, an FDA safety alert notes.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 11, 2018 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

International Laboratories, LLC Issues Voluntary Nationwide Recall of one (1) Lot of Clopidogrel Tablets USP, 75 mg packaged in bottles of 30 tablets Due to Mislabeling NDC # 54458-888-16; Lot # 117099A
International Laboratories, LLC is voluntarily recalling Lot# 117099A of Clopidogrel Tablets, USP 75 mg, packaged in bottles of 30 tablets, to the consumer level due to mislabeling. The product is labeled as Clopidogrel tablets USP 75 mg but may contain Clopidogrel 75mg or Simvastatin Tablets USP 10 mg. (Source: Food and Drug Administration)
Source: Food and Drug Administration - January 10, 2018 Category: Food Science Source Type: news

Clopidogrel After 1 Month in Stabilized ACS Patients Clopidogrel After 1 Month in Stabilized ACS Patients
A new study investigates switching from prasugrel or ticagrelor to clopidogrel vs. continuing either drug after a PCI for ACS. Will the results change clinical practice?European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 28, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

PRAGUE-18 Hints at Risk-Based Personalized DAPT After STEMI-PCI Discharge PRAGUE-18 Hints at Risk-Based Personalized DAPT After STEMI-PCI Discharge
Those who substituted clopidogrel for prasugrel or ticagrelor to avoid their steep out-of-pocket expense in the Czech trial, a lower-risk group as it turned out, didn't have more ischemic events.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 15, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Blood-thinning drugs may reduce dementia risk in people with irregular heartbeats
Conclusion If you’ve been diagnosed with AF and you have been prescribed anticoagulant treatments such as warfarin or clopidogrel, we already know they protect you against having a stroke. This study suggests they may also help to protect you against dementia. Cutting the risk of dementia for people who have a raised risk because of AF would be an exciting step forward. Unfortunately, we can’t tell from this study whether the protection against dementia was down to the anticoagulants, because of the possible effect of unmeasured confounding factors. Usually, we would want to see a randomised controlled trial (R...
Source: NHS News Feed - October 25, 2017 Category: Consumer Health News Tags: Neurology Source Type: news

You won ’t believe what happened this morning
When I got to the office this morning, several of my employees were in a state of near-panic… I couldn’t imagine what might have happened… and I was alarmed. Turns out, the coffee maker was on the fritz. Coffee is the “drug” of choice for many of the people on my staff. And they’re not alone… An astounding 80% of Americans use the caffeine in coffee to boost their energy. The buzz helps them wake up every morning and gets their day going. And older adults drink coffee more than anyone else. In fact, in a survey by the National Coffee Association, 20% of people over 64 said they ...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news

Judge: Firms must have permanent, physical presence in Delaware to file patent suits there
The District of Delaware Chief Judge said this week that businesses must have permanent residences in the state to be sued for patent infringement within it, following a series of US Supreme Court rulings, and transferred a patent spat case to Indiana. Chief Judge Leonard Stark said the precedent was set after the Supreme Court’s decision in TC Heartland LLC v. Kraft Food Group Brands and Bristol-Myers Squibb Co. v. Superior Court of California earlier this year. In TC Heartland v. Kraft Foods Group Brands, the Supremes limited the ability of patent holders to sue in other states. Kraft sued TC Heartland in...
Source: Mass Device - September 13, 2017 Category: Medical Devices Authors: Fink Densford Tags: Legal News Boston Scientific Cook Medical Source Type: news

Platelet Testing Guides Prasugrel-to-Clopidogrel Switch Post-ACS Platelet Testing Guides Prasugrel-to-Clopidogrel Switch Post-ACS
The TROPICAL-ACS trial has validated a new"deescalation" regimen of antiplatelet therapy that could be applicable to patients unsuitable for long-term potent therapy due to bleeding or affordability concerns.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 8, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Ticagrelor for DAPT Again Questioned in Modern-Era PCI for ACS Ticagrelor for DAPT Again Questioned in Modern-Era PCI for ACS
More bleeds than clopidogrel without a clinical upside: Maybe ticagrelor isn't the best for dual antiplatelet therapy in PCI for ACS, given the prowess of modern drug-eluting stents, researchers say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 30, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

ESC: Ticagrelor Fails to Improve on Clopidogrel After Switch
(MedPage Today) -- Single-center study contradicts PLATO in ACS patients (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 29, 2017 Category: Cardiology Source Type: news

FDA Drug Safety Communication: Reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug
[03-12-2010] The U.S. Food and Drug Administration (FDA) has added a Boxed Warning to the label for Plavix, the anti-blood clotting medication. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 3, 2017 Category: Drugs & Pharmacology Source Type: news

Late Stent Events Linked to Response to Clopidogrel, Not ASA
(MedPage Today) -- Longer-term trial data suggests limited value to platelet reactivity testing (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 3, 2017 Category: Cardiology Source Type: news

Medical device makers look to slip lawsuits on Supreme Court ruling
A trio of medical device makers are looking to slip patent infringement and product liability lawsuits based on recent U.S. Supreme Court rulings governing out-of-state lawsuits. In TC Heartland v. Kraft Foods Group Brands, the Supremes limited the ability of patent holders to sue in other states. Kraft sued TC Heartland in its incorporated state of Delaware over drink powder patents; a lower court blocked TC Heartland’s bid to move the case to its home base of Indiana. In May, the Supreme court reversed that decision, finding that the only place a defendant can be subject to a suit is their home court, a p...
Source: Mass Device - July 5, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Legal News Patent Infringement Abbott Boston Scientific Ethicon johnsonandjohnson Personal Injury stjudemedical Source Type: news

Supremes tighten the rules on out-of-state lawsuits
The Supreme Court this week put limits on where injuries lawsuits can be fired, siding with businesses to prevent plaintiffs from “shopping” for friendly courts. The justices overturned a lower court’s decision that had allowed out-of-state patients who took Bristol-Myers Squibb’s Plavix blood-thinning medication to file a suit against the company in California. Under the justice’s ruling, state courts cannot hear claims against companies that are not based in the state where the injuries occurred. The Supreme Court arrived at a similar conclusion in a separate case in May 30. Businesses can t...
Source: Mass Device - June 19, 2017 Category: Medical Devices Authors: Fink Densford Tags: Legal News Source Type: news

Prasugrel Fails to Show Noninferiority to Clopidogrel in Stroke Prasugrel Fails to Show Noninferiority to Clopidogrel in Stroke
Despite being a more potent antiplatelet agent, prasugrel failed to show noninferiority to clopidogrel in reducing vascular events in stroke patients in a new phase 3 trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 1, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

In ACS, Less Bleeding With Two-Step Post-PCI DAPT Strategy In ACS, Less Bleeding With Two-Step Post-PCI DAPT Strategy
Switching to clopidogrel after 1 month of prasugrel or ticagrelor reduces bleeding without increasing ischemic events in the open-label, single-center TOPIC study.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

DAPT Safer With Switch from P2Y12 Blockers Early After Stenting (CME/CE)
(MedPage Today) -- Substituting in clopidogrel after a month cuts bleeding risk, trial says (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 16, 2017 Category: Cardiology Source Type: news

Ischemic Outcomes Don ’ t Vary With Gender in ACS Patients
No difference by gender for ACS patients undergoing PCI receiving clopidogrel, prasugrel, or ticagrelor (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 4, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Gynecology, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pharmacy, Pulmonology, Journal, Source Type: news

Plavix (Clopidogrel Bisulfate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 28, 2017 Category: Drugs & Pharmacology Source Type: news

Platelet Function Testing Important With Pipeline Embolization Platelet Function Testing Important With Pipeline Embolization
Identification of patients who will be poor responders to antiplatelet therapy with clopidogrel can help avoid thromboembolic complications after flow diversion procedures for intracranial aneurysm.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 26, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Major Bleeding Risk From Drugs Similar in Elderly
Elderly taking aspirin, clopidogrel have major bleeding similar to that seen with oral anticoagulants (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 17, 2017 Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Nursing, Oncology, Pharmacy, Journal, Source Type: news

Are Blood Thinners Overused in Patients With Irregular Heartbeat?
FRIDAY, March 17, 2017 -- Many people living with the heart rhythm disorder known as atrial fibrillation may be taking unneeded blood thinners, a new study suggests. These blood thinners, which include aspirin, Plavix and warfarin, are believed to... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 17, 2017 Category: Journals (General) Source Type: news

TARDIS: Triple Antiplatelet Therapy No Benefit in Stroke, TIA TARDIS: Triple Antiplatelet Therapy No Benefit in Stroke, TIA
Triple antiplatelet therapy was not superior to guideline-recommended aspirin/dipyridamole or clopidogrel alone to prevent recurrent stroke in patients with recent stroke or TIA in the TARDIS trial.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - February 24, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Ticagrelor More Effective Than Clopidogrel in Some Cardiac Arrest Survivors Ticagrelor More Effective Than Clopidogrel in Some Cardiac Arrest Survivors
In comatose survivors of out-of-hospital cardiac arrest undergoing percutaneous coronary intervention (PCI) and hypothermia, ticagrelor results in faster and stronger platelet inhibition compared to clopidogrel, researchers in Slovenia say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2016 Category: Consumer Health News Tags: News Source Type: news

Kengreal Sans GPI Safe in PCI, With Less Bleeding (CME/CE)
(MedPage Today) -- Only TIMI bleeds differed from Plavix-GPI combo in meta-analysis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 1, 2016 Category: Cardiology Source Type: news

Cangrelor Sans GPI Safe in PCI, With Less Bleeding (CME/CE)
(MedPage Today) -- Only TIMI bleeds differed from Plavix-GPI combo in meta-analysis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 1, 2016 Category: Cardiology Source Type: news

Breaking News from AHA 2016: Genetic Risk & Healthy Lifestyle, Ticagrelor vs. Clopidogrel in PAD, Targeting PCSK9 (FREE)
By the Editors This week, NEJM Journal Watch is bringing you coverage of breaking news from the American Heart Association's Scientific Sessions in New Orleans. Take a look:Genetic Risk and Healthy Lifestyle: A healthy lifestyle can mitigate high genetic risk for coronary artery disease, according to an analysis of data … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 13, 2016 Category: Primary Care Source Type: news

EUCLID: Ticagrelor, Clopidogrel in PAD Similar for CV Events EUCLID: Ticagrelor, Clopidogrel in PAD Similar for CV Events
Those getting ticagrelor had fewer ischemic strokes, but that was only a part of the primary end point. It might have been related to the drug's effects on blood pressure, says an expert.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2016 Category: Consumer Health News Tags: Cardiology News Source Type: news