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Research makes advances to treat osteoarthritis pain

For the 8.8 million people in the UK with osteoarthritis, research into new treatments to tackle osteoarthritis pain has the potential to dramatically improve quality of life. That’s why supporting innovative research in this area is one of our priorities, accounting for 25% of our research funding. We asked Dr Fiona Watt, consultant rheumatologist and senior clinical research fellow at our Centre for Osteoarthritis Pathogenesis at the Kennedy Institute of Rheumatology in Oxford, to share some of the latest developments: “Most of the patients who walk through the door to my clinic want to know how I can help them with their pain. It’s undoubtedly the biggest issue facing people with osteoarthritis and a priority for us as researchers. I want to be able to treat people with osteoarthritis with drugs to reduce pain, but I also want to be able to prevent or slow down the process which drives the pain. Research over the last decade has shown us osteoarthritis isn't just caused by the joint surface wearing out.I want to be able to treat people with osteoarthritis with drugs to reduce pain, but I also want to be able to prevent or slow down the process which drives the pain. There are also processes we can measure in the joints which actively drive the progression of the disease which should be drug-treatable, perhaps by a tablet or an injection into the joint. To offer the best outcomes, just like with heart disease, we need to understand how we can identify th...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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Abstract The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptas...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
BACK pain can occur in the lower or upper areas of the back. Treatment for the condition includes stretching and taking medications to relieve the symptoms. Making this treat could help reduce your symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
A 3-year-old female presented with 4 months of recurrent fevers, abdominal pain, hematuria, and proteinuria with negative urine cultures. On examination, she was hypertensive with bruises over her left cheek. Labs were remarkable for serum creatinine 0.78 mg/dl (estimated glomerular filtration rate of 48.3 ml/min per 1.73 m2 using the revised Schwartz formula); hemoglobin 8.5 gm/dl; hematocrit 27.9%; platelet 92 × 103/ul; urinalysis with 11–20 red blood cells/high-power field; spot urine protein/creatinine ratio 1.97 mg/mg; low haptoglobin; elevated lactate dehydrogenase; and schistocytes on peripheral smear.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Chronic conditions – such as obesity, diabetes and heart disease – take an enormous physical toll on Americans every year. They also take a significant economic toll on individudals and employers alike, through missed work days, lost productivity, and higher health care costs and premiums. In fact, according to the Milken Institute, the annual economic impact of chronic disease in the U.S. is $1.3 trillion, with lost productivity accounting for the vast majority of that cost ($1.1 trillion).…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen are and have been the go-to “benign” pain medication for doctors and patients alike. Why? They aren’t addictive, and it’s not easy to overdose. Serious side effects like gastrointestinal ulcers and bleeding seemed to be limited to high doses taken for longer periods or time, or to people with significant medical problems. Even before the era of the opioid epidemic, it was raining NSAIDs, across the country. In 2004, the manufacturer of the NSAID Vioxx pulled it from the market because the drug was associated with serious...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Drugs and Supplements Headache Health Heart Health Injuries Pain Management Source Type: blogs
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study is a population-based cross-sectional study. In this study, 1117 participants aged 40–65 years and living in Shika Town completed a self-administered questionnaire including Short Form-36 (SF-36). The scores of SF-36 among hypertensives were compared with those of normotensives. The independent association of hypertension with each SF-36 subscale was analyzed using a multiple linear regression model adjusted by age, BMI, chronic pain, chronic diseases, sleep, exercise, and occupational status. We analyzed two groups; Group 1 which contained 846 participants completed the questionnaire without coronary...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
The FDA today released its list of the pre-market approvals it granted for medical devices in September 2015: Summary of PMA Originals &Supplements Approved Originals: 4 Supplements: 53 Summary of PMA Originals Under Review Total Under Review: 55 Total Active: 31 Total On Hold: 24 Summary of PMA Supplements Under Review Total Under Review: 611 Total Active: 461 Total On Hold: 150 Summary of All PMA Submissions Originals: 3 Supplements: 84 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 53 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 127.6 FDA Tim...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news
We examined a cardiovascular disease spectrum which consisted of hypertension, ischaemic heart disease and heart failure, and a musculoskeletal disease spectrum of lower back pain, osteoarthritis and rheumatoid arthritis. Using Medline, EMBASE and CINAHL databases, articles which had examined these morbidities and used either the SF-12 or SF-36 in general or primary care populations were selected; data was extracted independently by three reviewers. Study characteristics were described and the mean physical component summary scores of the SF-12 or SF-36 was analysed by disease, using random-effects meta-analysis. The assoc...
Source: Health and Quality of Life Outcomes - Category: Global & Universal Authors: Source Type: research
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