Research makes advances to treat osteoarthritis pain

For the 8.8 million people in the UK with osteoarthritis, research into new treatments to tackle osteoarthritis pain has the potential to dramatically improve quality of life. That’s why supporting innovative research in this area is one of our priorities, accounting for 25% of our research funding. We asked Dr Fiona Watt, consultant rheumatologist and senior clinical research fellow at our Centre for Osteoarthritis Pathogenesis at the Kennedy Institute of Rheumatology in Oxford, to share some of the latest developments: “Most of the patients who walk through the door to my clinic want to know how I can help them with their pain. It’s undoubtedly the biggest issue facing people with osteoarthritis and a priority for us as researchers. I want to be able to treat people with osteoarthritis with drugs to reduce pain, but I also want to be able to prevent or slow down the process which drives the pain. Research over the last decade has shown us osteoarthritis isn't just caused by the joint surface wearing out.I want to be able to treat people with osteoarthritis with drugs to reduce pain, but I also want to be able to prevent or slow down the process which drives the pain. There are also processes we can measure in the joints which actively drive the progression of the disease which should be drug-treatable, perhaps by a tablet or an injection into the joint. To offer the best outcomes, just like with heart disease, we need to understand how we can identify th...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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Authors: Gentile E, Ricci K, Delussi M, Brighina F, de Tommaso M Abstract Previous studies indicated changes of motor cortex excitability in fibromyalgia (FM) patients and the positive results of transcranial stimulation techniques. The present study aimed to explore the metabolism of motor cortex in FM patients, in resting state and during slow and fast finger tapping, using functional Near-Infrared Spectroscopy (fNIRS), an optical method which detects in real time the metabolism changes in the cortical tissue. We studied 24 FM patients and 24 healthy subjects. We found a significant slowness of motor speed in FM ...
Source: Pain Research and Treatment - Category: Anesthesiology Tags: Pain Res Treat Source Type: research
Conclusions: The use of mHealth for obese adults showed a modest short-term effect on body weight and BMI. Although the weight loss associated with mHealth did not meet the recommendation of the Scottish Intercollegiate Guideline Network, which considers a reduction of approximately 5 to 10 kg of the initial body weight as a successful intervention. Well-designed RCTs are needed to reveal the effects of mHealth interventions. PMID: 30788177 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
The indications for cryoablation in pediatric patients has been slowly growing over the last few years. Vascular anomalies and solid tumors are being treated with this modality. However, cryoablation can be associated with local complications. This is of high relevance in children due to smaller body surface area, more compact anatomy and less subcutaneous fat. Additionally, these patients have lower tolerance to pain and inflammation. It is critical to understand these factors when using cryoablation to treat pediatric patients.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 5: You ’ve Got To Be Kid-ing Me (Pediatric IR) Source Type: research
A new research review has plenty of good news for people who love a good sauna session: Studies overwhelmingly suggest that the relaxing habit is also a healthy one. A paper published Wednesday in Mayo Clinic Proceedings gathered existing findings on Finnish sauna bathing, the practice of spending time in relatively dry rooms heated to between 80 and 100 degrees, interspersed with periods of cooling. The results were culled from more than 70 studies published up through February 2018. Overall, the research suggests that “sauna bathing, an activity used for the purposes of pleasure, wellness, and relaxation, is linked...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen are and have been the go-to “benign” pain medication for doctors and patients alike. Why? They aren’t addictive, and it’s not easy to overdose. Serious side effects like gastrointestinal ulcers and bleeding seemed to be limited to high doses taken for longer periods or time, or to people with significant medical problems. Even before the era of the opioid epidemic, it was raining NSAIDs, across the country. In 2004, the manufacturer of the NSAID Vioxx pulled it from the market because the drug was associated with serious...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Drugs and Supplements Headache Health Heart Health Injuries Pain Management Source Type: blogs
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study is a population-based cross-sectional study. In this study, 1117 participants aged 40–65 years and living in Shika Town completed a self-administered questionnaire including Short Form-36 (SF-36). The scores of SF-36 among hypertensives were compared with those of normotensives. The independent association of hypertension with each SF-36 subscale was analyzed using a multiple linear regression model adjusted by age, BMI, chronic pain, chronic diseases, sleep, exercise, and occupational status. We analyzed two groups; Group 1 which contained 846 participants completed the questionnaire without coronary...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
The FDA today released its list of the pre-market approvals it granted for medical devices in September 2015: Summary of PMA Originals &Supplements Approved Originals: 4 Supplements: 53 Summary of PMA Originals Under Review Total Under Review: 55 Total Active: 31 Total On Hold: 24 Summary of PMA Supplements Under Review Total Under Review: 611 Total Active: 461 Total On Hold: 150 Summary of All PMA Submissions Originals: 3 Supplements: 84 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 53 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 127.6 FDA Tim...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news
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