Epidemiology of Chikungunya Virus in Bahia, Brazil, 2014-2015

Article The Chikungunya virus (CHIKV) is an alphavirus that belongs to the Semliki Forest Virus antigenic complex1. Local outbreaks of CHIKV-like disease have been documented since the eighteenth century2 and the virus was discovered in 1952 in Tanzania3 . Over the last 50 years, CHIKV has spread beyond its African heartlands and caused explosive outbreaks comprising millions of cases in Indian Ocean islands and Asia.4The virus is mosquito-borne and transmission is associated with the vector species Aedes albopictus and Ae. aegypti, which are responsible for transmission cycles in urban and peri-urban environments5. Clinical symptoms include polyarthralgia, rash, high fever and severe headaches6 and outbreaks are often characterized by a rapid spread and high morbidity, resulting in losses in productivity7. To date, four distinct CHIKV genotypes have been identified. Two genotypes – the East-Central-South African (ECSA) and the West African genotypes – occupy a basal position in the phylogeny of CHIKV8 and are mostly enzootic in Africa. Of the remaining two genotypes, the Asian genotype is predominant in Southeast Asia, whilst the more recent Indian Ocean lineage spread from the Comoros islands in 2004 and caused a large outbreak in India and Southeast Asia in 2005-2008. In October 2013, the Asian genotype was first reported in the Americas, in the island of Saint Martin in the Caribbean9. By the end of December 2015, nearly 1 million cases had been notified in ...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Publication date: Available online 15 December 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): Elena V. Romanova, Yurij S. Bukin, Kirill V. Mikhailov, Maria D. Logacheva, Vladimir V. Aleoshin, Dmitry Yu. SherbakovAbstractThe evolution of tRNA genes in mitochondrial (mt) genomes is a complex process that includes duplications, degenerations, and transpositions, as well as a specific process of identity change through mutations in the anticodon (tRNA gene remolding or tRNA gene recruitment). Using amphipod-specific tRNA models for annotation, we show that tRNA duplications are more common in the mt genomes of amp...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Conclusions: Treatment with biologics affects the cytokine profile in inflammatory synovial fluid in patients with both AS and RA. Furthermore, IL-23 and IL-17 cytokine might be an important factor in some patients who are unresponsive to biologics in AS. PMID: 31830775 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
ConclusionsDental-related pain is often managed by nondental health care professionals in an ED or urgent care setting. An EHR alert may help quickly identify high-risk patients; however, the impact of alerts on prescribing patterns needs further evaluation. The decision regarding the type and quantity of medication to prescribe is complicated by lack of patient access to definitive dental treatment and lack of dental-specific training of prescribers. The limitations of this study include selective inclusion of encounters with specific ICD-9/ICD-10 codes, data limited to objectively searchable criteria, data collection for...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
This study aimed to identify the best anatomic area of cervical region of corpses to propose an extraoral LLLT protocol for treating HPM, as well as to evaluate odynophagia in patients treated at a universitary hospital in southern Brazil. An anatomic study in corpses was performed selecting the best extraoral site to apply LLLT for treating HPM. Furthermore, statements about extraoral LLLT were reported by patients complaining of odynophagia. The carotid trigone showed to be the best site to perform LLLT. Laser protocol to treat HPM consisted in: infrared, 4 J, 100 mW, and 4 points along the anterior margin of sternocleid...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusions: PCM occur predominantly in white men, and the main clinical aspect was painful mulberry-like ulcer on the tongue. The recognition of oral lesions is important because sometimes they are the first manifestation of PCM, frequently preceding even pulmonary lesions.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsThis study reports the first DENV detection in saliva of BALB/c immunocompetent mice experimentally infected with nonneuroadapted DENV-4.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsClinical care in the area of stomatology offered to population of 7 cities by the CEO presents fundamental importance in the diagnosis and treatment of oral cavity lesions.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsOur results reinforce the distinct orofacial features of ERS, which are the clue for kidney examination and genetic testing. Here we report the largest series of patients with ERS of the same population, and describe, for the first time, a founder mutation for FAM20A gene. FAPEMIG, FAPESP, CAPES.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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