Benefits of using heterologous polyclonal antibodies and potential application to new and undertreated infectious pathogens.

CONCLUSIONS: Polyclonal antibodies have been successfully applied to rabies, envenomation and intoxication. Polyclonal production provides an exciting opportunity to revolutionise the prognosis of both longstanding neglected tropical diseases as well as emerging infectious threats to humans. PMID: 26802604 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Publication date: Available online 10 December 2019Source: Parasitology InternationalAuthor(s): L. Buffoni, M.M. Piva, P. Baska, K. Januszkiewicz, L.J. Norbury, K.C. Prior, D. Dezen, A.S. Silva, H. Wedrychowiczhz, R.E. MendesAbstractThe aim of this study was to assess the immune response and the protective efficacy elicited by the vaccination with the recombinant Fasciola hepatica myosin regulatory light chain (FhrMRLC) in Adjuplex® adjuvant against the infection with F. hepatica in rats. Four groups of 15 animals each were used for the study, one group was immunized with the recombinant F. hepatica MRLC in Adjuplex&re...
Source: Parasitology International - Category: Parasitology Source Type: research
In this study, we generated two recombinant RABVs, rERAG333E/NiVG and rERAG333E/NiVF, expressing the NiV Malaysian strain attachment glycoprotein (NiV-G) or fusion glycoprotein (NiV-F) gene based on the rERAG333E vector platform. Both rERAG333E/NiVG and rERAG333E/NiVF displayed growth properties similar to those of rERAG333E and caused marked syncytia formation after co-infection in BSR cell culture. Adult and suckling mice intracerebrally inoculated with the recombinant RABVs showed NiV-G and NiV-F expression did not increase the virulence of rERAG333E. Oral vaccination with rERAG333E/NiVG either singularly or combined wi...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Conclusion: Vulnerable populations were found to be less knowledgeable on risk factors and they had poor practice. Education had significant impact on knowledge and attitude of urban population; however, their practice did not improve with education. PMID: 31815581 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: Available online 11 December 2019Source: Life SciencesAuthor(s): Rui Yan, JianJian Li, Ying Zhou, Li Yao, Ruya Sun, Ying Xu, Yang Ge, Guangyu AnAbstractImmunotherapy is one of the most promising strategies for cancer, compared with traditional treatments. As one of the key emerging immunotherapies, anti-PD-1/PD-L1 treatment has brought survival benefits to many advanced cancer patients. However, in pancreatic cancer, immunotherapy-based approaches have not achieved a favorable clinical effect because of mismatch repair deficiencies. Therefore, the majority of pancreatic tumors are regarded as immune-quies...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 11 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Saekil Yun, Seung-Jun Lee, Sib Sankar Giri, Hyoun Joong Kim, Sang Geun Kim, Sang Wha Kim, Se Jin Han, Jun Kwon, Woo Taek Oh, Se Chang ParkAbstractThe aim of this study was to develop and evaluate a novel route of administration for vaccinating fish against Aeromonas hydrophila infection using a dissolving microneedles (MNs) patch. The A. hydrophila JUNAH strain was inactivated with formalin and used as a vaccine antigen. It was mixed with dissolvable carboxymethyl cellulose (CMC) as the matrix material to produce the MNs pat...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Authors: Abstract "My biggest motivation is the discovery of new therapeutics to save lives. The most significant scientific advance of the last 100 years has been the discovery of polio vaccine …" Find out more about Yanli Zhao in his Author Profile. PMID: 31816177 [PubMed - in process]
Source: Angewandte Chemie - Category: Chemistry Tags: Angew Chem Int Ed Engl Source Type: research
A number of birds at a commercial farm in Suffolk were found to have the H5 strain of avian flu, the Department for Environment, Food and Rural Affairs said on Tuesday.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
BIRD flu has been confirmed on a farm in Suffolk and to limit the risk of the disease spreading a one-kilometre exclusion zone has been set up and nearly 30,000 chickens will be culled. Also known as avian flu, what ’s the risk of humans becoming infected?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
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