Abstract LB-181: Oral HPV DNA detection and subsequent risk of head and neck cancers in two prospective cohorts

Conclusion: This study is the first to demonstrate that alpha HPV16 detection precedes the incidence of oropharyngeal cancers. Risks identified with other HPV types from gamma11 and 12 species as well as beta HPV5, previously associated with skin cancer, suggests a broader role for HPVs in HNSCC etiology. Readily-collected oral wash samples provide a strong prospective marker for oropharyngeal cancer and, with the incorporation of other HPV types, may indicate risk for a broader spectrum of HNSCC.Citation Format: Ilir Agalliu, Zigui Chen, Tao Wang, Rebecca Ludvigsen, Lauren Teras, Aimee R. Kreimer, Richard B. Hayes, Susan Gapstur, Robert D. Burk. Oral HPV DNA detection and subsequent risk of head and neck cancers in two prospective cohorts. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-181. doi:10.1158/1538-7445.AM2015-LB-181
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Epidemiology Source Type: research