LDL-C and TC mediate the risk of PNPLA3 inhibition on cardiovascular diseases

CONCLUSION: This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.PMID:38636099 | DOI:10.1210/clinem/dgae264

Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Genshan Zhang Wei Jiang Fangxun He Jie Fu Xiangshang Xu Xuelai Luo Zhixin Cao Source Type: research