Gut-Liver-Brain Axis and Alcohol Use Disorder: Treatment Potential of Fecal Microbiota Transplantation

CONCLUSIONS: The literature search identified only a few studies that were directly investigating the effect of FMT on ALD or alcohol drinking and related behaviors. Largely proof-of-concept studies, these findings demonstrate that alcohol can alter the gut microbiome and that the microbiome can be transferred between humans and rodents to alter affective behaviors frequently associated with increased alcohol use. Other studies have shown promise of FMT or other probiotic supplementation in alleviating some of the symptoms associated with ALD and drinking. These results show that the implementation of FMT as a therapeutic approach is still in the investigatory stages.PMID:38322428 | PMC:PMC10843328 | DOI:10.35946/arcr.v44.1.01

Source: Alcohol Research - February 7, 2024 Category: Addiction Authors: Jennifer T Wolstenholme Nikki K Duong Emily R Brocato Jasmohan S Bajaj Source Type: research