The Pathophysiological Associations Between Obesity, NAFLD, and Atherosclerotic Cardiovascular Diseases
Horm Metab Res DOI: 10.1055/a-2266-1503Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic
cardiovascular diseases are common and growing public health concerns. Previous
epidemiological studies unfolded the robust correlation between obesity, NAFLD,
and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor
for NAFLD, and both of them can markedly increase the odds of atherosclerotic
cardiovascular diseases. On the other hand, significant weight loss achieved by
lifestyle modification, bariatric surgery, or medications, such as semaglutide,
can concomitantly improve NAFLD and atherosclerotic cardiovascular diseases.
Therefore, certain pathophysiological links are involved in the development of
NAFLD in obesity, and atherosclerotic cardiovascular diseases in obesity and
NAFLD. Moreover, recent studies indicated that simultaneously targeting several
mechanisms by tirzepatide and retatrutide leads to greater weight loss and
markedly improves the complications of metabolic syndrome. These findings remind
the importance of a mechanistic viewpoint for breaking the association between
obesity, NAFLD, and atherosclerotic cardiovascular diseases. In this review
article, we mainly focus on shared pathophysiological mechanisms, including
insulin resistance, dyslipidemia, GLP1 signaling, ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Li, Meng Cui, Man Li, Guoxia Liu, Yueqiu Xu, Yunsheng Eftekhar, Seyed Parsa Ala, Moein Tags: Review Source Type: research
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