Physician Approaches to the Pharmacologic Treatment of Dystonia in Cerebral Palsy

CONCLUSIONS: This study summarizes current indications and dosing for the six most commonly used medications to treat dystonia in CP as per treating physicians in the US and Canada and also demonstrates physician support for a randomized trial comparing the effectiveness of these treatments.ARTICLE SUMMARY: Dystonia is common and debilitating in people with CP, with little data on pharmacologic treatments. We describe physicians' current approaches to using these treatments.WHAT’S KNOWN ON THIS SUBJECT: Comparing the effectiveness of existing pharmacologic treatments for dystonia in CP is a research priority shared by clinicians and the community. However, current pharmacologic treatment practices are unknown.WHAT THIS STUDY ADDS: Physicians in the US and Canada primarily prescribe a subset of six medications for the treatment of functionally limiting and generalized dystonia in CP: baclofen, trihexyphenidyl, gabapentin, carbidopa/levodopa, clonazepam, and diazepam.CONTRIBUTORS STATEMENT: Emma Lott helped design the study, carried out data analyses, and critically reviewed and revised the manuscript.Darcy Fehlings, Rose Gelineau-Morel, Michael Kruer, Jonathan Mink, Sruthi Thomas, and Steve Wisniewski helped design the study and critically reviewed and revised the manuscript.Bhooma Aravamuthan conceptualized and designed the study, supervised data collection and analysis, drafted the initial manuscript, and critically reviewed and revised the manuscript.PMID:38352331 | PMC:P...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research