Bevacizumab May Be Next Standard of Care for Mesothelioma

Discussions About Mesothelioma at ASCO Meeting There were other abstracts involving mesothelioma presented at the ASCO, adding even more optimism about potential treatment advances. Dr. Raffit Hassan, mesothelioma specialist from the National Cancer Institute, detailed results of a phase I trial involving immunotherapy drug CRS-207 in combination with standard chemotherapy. Disease control was obtained in 30 of the 32 trial participants. There was partial response in 19 patients and stable disease in 11. CRS-207 is given by vaccination. Median duration of response was 5 months and median progression-free survival was 7.4 months. Dr. Diego Cortinovis, San Gerardo Hospital in Monza, Italy, reported impressive results for the anti-tumor drug trabectedin in a phase II study involving second-line treatment for sarcomatoid/biphasic mesothelioma. Trabectedin has been used effectively in soft-tissue sarcomas and for relapsed ovarian cancers.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Publication date: Available online 19 June 2019Source: Biosensors and BioelectronicsAuthor(s): Sattar Akbari Nakhjavani, Hadi Afsharan, Balal Khalilzadeh, Mohammad Hossein Ghahremani, Sandro Carrara, Yadollah OmidiAbstractCarcinoembryonic antigen (CEA) is an important oncomarker for the detection of breast cancer. For ultra-sensitive sensing of CEA with great specificity and accuracy, an innovative and reliable electrochemical immunosensor was developed using various nano-hybrids. A glassy carbon electrode (GC) was modified with thiolated graphene oxide (T-GO) to elevate the active surface area of the electrode. The strept...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 19 June 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Diana C. Márquez-Garbán, Gang Deng, Begonya Comin-Anduix, Alejandro J. Garcia, Yanpeng Xing, Hsiao-Wang Chen, Gardenia Cheung-Lau, Nalo Hamilton, Michael E. Jung, Richard J. PietrasAbstractBreast cancers (BC) with expression of estrogen receptor-alpha (ERα) occur in more than 70% of newly-diagnosed patients in the U.S. Endocrine therapy with antiestrogens or aromatase inhibitors is an important intervention for BCs that express ERα, and it remains one of the most effective tar...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Marina V. Novoselova, Denis V. Voronin, Tatiana O. Abakumova, Polina A. Demina, Arsenii V. Petrov, Vladimir V. Petrov, Timofei S. Zatsepin, Gleb B. Sukhorukov, Dmitry A. GorinAbstractHigh intensity focused ultrasound (HIFU) is widely used in medical practice, including cancer therapy. Also this approach is promising for remote release of encapsulated drugs in various other biomedical applications where local treatment is needed. Our approach underpins the minimization of HIFU impact on possible degradation of biological t...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 June 2019Source: Chemico-Biological InteractionsAuthor(s): Yeonhwa Song, I-Seul Park, Jiho Kim, Inhee Choi, Haeng Ran SeoAbstractLiver cancer is one of the most frequently occurring types of cancer with high mortality rate. Hepatocellular carcinoma (HCC) frequently metastasizes to lung, portal vein, and portal lymph nodes and most HCCs show strong resistance to conventional anticancer drugs. Cancer stem cells (CSCs) are considered to be responsible for resistance to therapies. Hence, recent advancements in the use of liver cancer stem cells (LCSCs) are rapidly gaining recognition as an...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 1 November 2019Source: Chemical Engineering Journal, Volume 375Author(s): Huayan Yang, Yanmin Zhang, Jian Song, Meng Wang, Shaoning Yu, Liang Chen, Xiaomin Li, Shouning Yang, Lin YangAbstractThe integration of photothermal therapy (PTT) with photodynamic therapy (PDT) has great potential to revolutionize conventional therapeutic approaches for cancers. However, most of the currently developed nanoplatforms for combinatorial phototherapy require the participation of different components or activation of separate lasers. Therefore, a desirable photoactive agent with intrinsic single laser-activated combinat...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Dalton Trans., 2019, Advance Article DOI: 10.1039/C9DT01841G, PaperGuofeng Liu, Yeqing Chen, Mochen Jia, Zhen Sun, Binbin Ding, Shuai Shao, Fan Jiang, Zuoling Fu, Ping'an Ma, Jun Lin After loaded with platinum (IV), the Gd2(WO4)3:Yb3+/Ho3+@SiO2 nanoparticles prepared by a one-pot co-precipitation for the first time were used for multimode imaging and cancer treatment. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC03480C, CommunicationQian Cao, Jing Yang, Hang Zhang, Liang Hao, Gang-Gang Yang, Liang-Nian Ji, Zong-Wan Mao A facile and cheap strategy based on visualized in-cell synthesis of theranostic Zn Schiff base complexes realizes cancer-specific therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
Conclusions: The use of healthcare services among sarcoma patients increased several months before diagnosis in all healthcare sectors. The results reveal a diagnostic time window and a potential to refer, diagnose, and treat sarcoma patients in a timelier manner. PMID: 31205448 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Authors: De Goycoechea D, Stalder G, Martins F, Duchosal MA Abstract Immune checkpoint inhibition (ICI) became one of the major breakthroughs in cancer treatment over the past decade and entered into therapy within standard oncohematology practice. ICI has demonstrated impressive response rates as salvage therapy in relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) and is now being tested as an adjunction to chemotherapy in the frontline settings. CHL exquisite sensitivity to PD-1/PD-L1 axis inhibition relies on a particular biological background. By contrast, non-Hodgkin lymphomas (NHL) have demonstrated ...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
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