Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer

ConclusionsThe established organoids with characteristics of MSI-H cancers can be used to study MMRd cancer biology. The orthotopic model, with its distant metastasis and expressing frameshift peptides, is suitable for evaluating the efficacy of neoantigen-based vaccines or anticancer drugs in combination with other therapies.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research