Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head

Discussion
Hyponatremia in patients with anti-LGI1 antibody encephalitis is due to SIADH as previously assumed. Other electrolyte abnormalities such as hypomagnesemia and hypophosphatemia occur in at least 40% of patients and may be another clue for the diagnosis of anti-LGI1 antibody encephalitis. Because we failed to demonstrate LGI1 expression in the kidney, the results of our study suggest that renal losses lead to these disturbances, most probably due to SIADH.

Source: Neurology Neuroimmunology and Neuroinflammation - August 17, 2023 Category: Neurology Authors: Gadoth, A., Nisnboym Ziv, M., Alcalay, Y., Zubkov, A., Schwartz, I., Schwartz, D., Abboud, M., Rubinek, T., Yossepowitch, O., Weinstein, T. Tags: All Immunology, Autoimmune diseases, All Clinical Neurology, All Epilepsy/Seizures Research Article Source Type: research