E-261 Variability of response on prophylactic prasugrel for endovascular treatment of intracranial aneurysms: clinical implications

ConclusionIn the neurointerventional field, high BMI and prior use of antithrombotic agents were related to HTPR, and low BMI was associated with LTPR on prophylactic prasugrel. High hematocrit levels decreased the risk of HTPR. When preparing endovascular treatment for intracranial aneurysms, attention to patients with these clinical features is required to address the possibility of ischemic or bleeding complications.Abstract E-261 Table 1Risk factor analysis of high on-treatment platelet reactivity (HTPR) Variables Univariate Analysis Multivariate Analysis OR (95% CI) P OR (95% CI) P Age 1.02 (0.97-1.06) 0.53 Female over male 0.66 (0.25-1.77) 0.41 BMI 1.17 (1.01-1.34) 0.03 1.21 (1.04-1.41) 0.01 Hypertension 1.93 (0.67-5.57) 0.22 Diabetes mellitus 1.70 (0.57-5.06) 0.34 Chronic kidney disease 0.00 (0.00-) 1.00 Arrhythmia 0.00 (0.00-) 0.99 Coronary heart disease 2.60 (0.50-13.49) 0.25 Previous ischemic stroke 1.22 (0.38-3.93) 0.73 Current smoking 1.08 (0.29-3.97) 0.91 Alcohol consumption 0.60 (0.21-1.73) 0.35 Drug history of antithrombotics 2.96 (1.16-7.58) 0.02 3.79 (1.39-10.34) 0.01 Drug history of proton-pump inhibitors 3.47 (1.12-10.87) 0.03 Level of LDL cholesterol 1.00 (0.99-1.02) 0.89 Level of HDL cholesterol 0.98 (0.94-1.01) 0.21 Platelet count 0.99 (0.99-1.01) 0.65 Hematocrit 0.94 (0.88-1.02) 0.13 0.91 (0.84-0.99) 0.03 BMI, body mass index; CI, confidence interval; high-density lipoprotein; LDL, low-density lipoprotein; OR, odds ratioAbstract E-261 Table 2Risk ...

Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Son, Y., Hong, N. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research