Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study
CONCLUSIONS AND RELEVANCE: Our results suggest that joint inhibition of CETP and PCSK9 has additive effects on lipid traits and disease risk, including a lower risk of CAD. Further research may explore whether a combination of CETP- and PCSK9-related therapeutics can benefit high-risk patients who are unable to reach treatment targets with existing options.PMID:35921096 | DOI:10.1001/jamacardio.2022.2333
Source: Atherosclerosis - Category: Cardiology Authors: Arjen J Cupido Laurens F Reeskamp Aroon D Hingorani Chris Finan Folkert W Asselbergs G Kees Hovingh Amand F Schmidt Source Type: research
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