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Melatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit
Pflugers Arch. 2024 May 14. doi: 10.1007/s00424-024-02968-3. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is considered a severe disease mitigating lung physiological functions with high mortality outcomes, insufficient therapy, and pathophysiology pathways which is still not fully understood. Mesenchymal stem cells (MSCs) derived from bone marrow play an important role in improving the function of organs suffering inflammation, oxidative stress, and immune reaction. It might also play a role in regenerative medicine, but that is still questionable. Additionally, Melatonin with its known antio...
Source: Pflugers Archiv : European Journal of Physiology - May 13, 2024 Category: Physiology Authors: Mira Hanna Sabreen Sayed Elnassag Dina Hisham Mohamed Marawan Abd Elbaset Olfat Shaker Effat A Khowailed Sarah Ali Abdelhameed Gouda Source Type: research

Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo
Pflugers Arch. 2024 May 7. doi: 10.1007/s00424-024-02969-2. Online ahead of print.ABSTRACTCells of the immune defence, especially leukocytes, often have to perform their function in tissue areas that are characterized by oxygen deficiency, so-called hypoxia. Physiological hypoxia significantly affects leukocyte function and controls the innate and adaptive immune response mainly through transcriptional gene regulation via the hypoxia-inducible factors (HIFs). Multiple pathogens including components of bacteria, such as lipopolysaccharides (LPS) trigger the activation of leukocytes. HIF pathway activation enables immune cel...
Source: Pflugers Archiv : European Journal of Physiology - May 7, 2024 Category: Physiology Authors: Tina Sch önberger Marie Jakobs Anna-Lena Friedel Tina H örbelt-Grünheidt Bastian Tebbe Oliver Witzke Manfred Schedlowski Joachim Fandrey Source Type: research

Correction to: pH ‑regulated single cell migration
Pflugers Arch. 2024 May 8. doi: 10.1007/s00424-024-02970-9. Online ahead of print.NO ABSTRACTPMID:38714573 | DOI:10.1007/s00424-024-02970-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - May 7, 2024 Category: Physiology Authors: Christian Stock Source Type: research

Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors
Pflugers Arch. 2024 May 4. doi: 10.1007/s00424-024-02962-9. Online ahead of print.ABSTRACTArrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable, long-term, non-invasive, or minimally invasive methods for cardiac arrhythmia follow-up in large animals that allows free movement with littermates. A long follow-up time is needed when estimating the impact of long-lasting drugs or therapies, such as gene therapy. We evaluated the feasibility and perf...
Source: Pflugers Archiv : European Journal of Physiology - May 4, 2024 Category: Physiology Authors: Jonna Airaksinen Satu Siimes Juha Hartikainen Seppo Yl ä-Herttuala Source Type: research