Long-term efficacy of antipsychotic drugs in initially acutely ill adults with schizophrenia: systematic review and network meta-analysis
We examined the long-term efficacy of antipsychotic drugs in acutely ill patients using network meta-analysis. We searched the Cochrane Schizophrenia Group register up to March 6, 2022 for randomized, blinded trials of at least 6-month duration on all second-generation and 18 first-generation antipsychotics. The primary outcome was change in overall symptoms of schizophrenia; secondary outcomes were all-cause discontinuation; change in positive, negative and depressive symptoms; quality of life, social functioning, weight gain, antiparkinson medication use, akathisia, serum prolactin level, QTc prolongation, and sedation. ...
Source: World Psychiatry - May 9, 2023 Category: Psychiatry Authors: Stefan Leucht Johannes Schneider-Thoma Angelika Burschinski Natalie Peter Dongfang Wang Shimeng Dong Maximilian Huhn Adriani Nikolakopoulou Georgia Salanti John M Davis Source Type: research
The safety and efficacy of sequential intramuscular/oral ziprasidone treatment of acute episode in patients with schizophrenia: a multicenter, open-labeled study
Ziprasidone mesylate injection is an atypical antipsychotic drug which is recently approved in China. In combination with its oral formulation, sequential therapy with ziprasidone brings new interventions to p... (Source: BMC Psychiatry)
Source: BMC Psychiatry - March 15, 2023 Category: Psychiatry Authors: Yaxue Wu, Yanli Li, Weiye Liang, Luyuan Bai, Jianjin Yu, Keqing Li, Yunshu Zhang, Yanmei Guo, Zenglong Liu, Jian Wang, Congpei Zhang, Xijin Wang, Jia Xu, Liping Liu, Juan Li and Fude Yang Tags: Research Source Type: research
Comparison of antipsychotic dose equivalents for acute bipolar mania and schizophrenia
Conclusions
Antipsychotic drugs have been considered first-line treatment for acute mania, warranting specific dose equivalence for scientific and clinical purposes. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - February 7, 2023 Category: Psychiatry & Psychology Authors: Yu, C.-L., Carvalho, A. F., Thompson, T., Tsai, T.-C., Tseng, P.-T., Hsu, C.-W., Hsu, T.-W., Liang, C.-S. Tags: Open access Statistics Source Type: research
Agonistic properties of a series of psychotropic drugs at 5-HT < sub > 1A < /sub > receptors in rat and human brain membranes determined by [ < sup > 35 < /sup > S]GTP γS binding assay
CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.PMID:36637685 | DOI:10.1007/s43440-023-00448-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2023 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masaki Mikami Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Dasiel Oscar Borroto-Escuela Kjell Fuxe Source Type: research
Agonistic properties of a series of psychotropic drugs at 5-HT < sub > 1A < /sub > receptors in rat and human brain membranes determined by [ < sup > 35 < /sup > S]GTP γS binding assay
CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.PMID:36637685 | DOI:10.1007/s43440-023-00448-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2023 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masaki Mikami Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Dasiel Oscar Borroto-Escuela Kjell Fuxe Source Type: research
Agonistic properties of a series of psychotropic drugs at 5-HT < sub > 1A < /sub > receptors in rat and human brain membranes determined by [ < sup > 35 < /sup > S]GTP γS binding assay
CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.PMID:36637685 | DOI:10.1007/s43440-023-00448-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2023 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masaki Mikami Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Dasiel Oscar Borroto-Escuela Kjell Fuxe Source Type: research
Agonistic properties of a series of psychotropic drugs at 5-HT < sub > 1A < /sub > receptors in rat and human brain membranes determined by [ < sup > 35 < /sup > S]GTP γS binding assay
CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.PMID:36637685 | DOI:10.1007/s43440-023-00448-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2023 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masaki Mikami Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Dasiel Oscar Borroto-Escuela Kjell Fuxe Source Type: research
Levetiracetam Associated Behavioral Adverse Events in Neurocritical Care Patients
ConclusionIn this study, we found that almost half of our NCC population experienced levetiracetam associated BAEs which were mostly hyperactive in nature. We believe that the incidence of BAEs in our specific patient population cannot solely be attributed to ICU delirium given the lower risk of developing hyperactive delirium in ICU patients as compared to other subtypes. Therefore, monitoring and determination of the benefit versus risk in those experiencing BAEs is highly encouraged. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - January 6, 2023 Category: Drugs & Pharmacology Authors: Micheal Strein,
John P. Holton ‐Burke,
Spiro Stilianoudakis,
Carley Moses,
Sulaiman Almohaish,
Gretchen M. Brophy Tags: RESEARCH ARTICLE Source Type: research
The Role of Total White Blood Cell Count in Antipsychotic Treatment for Patients with Schizophrenia
CONCLUSION: TWBCc is affected by certain antipsychotics among patients with schizophrenia, with decreases observed following short-term, but increases following long-term treatment. TWBCc is predictive of drug response, with lower TWBCc predicting better responses to antipsychotics. It also mediates the effects of certain metabolic measures on improvement of negative symptoms. This.PMID:36600620 | DOI:10.2174/1570159X21666230104090046 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - January 5, 2023 Category: Drugs & Pharmacology Authors: Yamin Zhang Shiwan Tao Jeremy Coid Wei Wei Qiang Wang Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang None Lingjiang Chuanyue Wang Liansheng Source Type: research
Antipsychotics and risk of QT prolongation: a pharmacovigilance study
ConclusionsThis large study in a real-world setting suggests that sertindole and ziprasidone were the antipsychotics drugs associated with the highest risk of QT prolongation reporting. Our results suggest that lurasidone is less associated with QT interval prolongation reports. Our study also suggests that antipsychotics with the higher hERG affinity are more associated with to QT prolongations reports. (Source: Psychopharmacology)
Source: Psychopharmacology - December 14, 2022 Category: Psychiatry Source Type: research
Early Efficacy of Antipsychotic Medications at Week 2 Predicts Subsequent Responses at Week 6 in a Large-scale Randomized Controlled Trial
CONCLUSIONS: It is robust enough to clinically predict treatment responses to antipsychotics at week 6 using the reduction rate of PANSS total score and symptom relief at week 2. Psychiatric clinicians had better determine whether to switch the treatment plan by the first 2 weeks.PMID:36411567 | DOI:10.2174/1570159X21666221118164612 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 22, 2022 Category: Drugs & Pharmacology Authors: Yiguo Tang Yulu Wu Xiaojing Li QinJian Hao Wei Deng Weihua Yue Hao Yan Yamin Zhang Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fude Yang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Lingjiang Li Chuanyue Wang Xi Source Type: research
Early Efficacy of Antipsychotic Medications at Week 2 Predicts Subsequent Responses at Week 6 in a Large-scale Randomized Controlled Trial
CONCLUSIONS: It is robust enough to clinically predict treatment responses to antipsychotics at week 6 using the reduction rate of PANSS total score and symptom relief at week 2. Psychiatric clinicians had better determine whether to switch the treatment plan by the first 2 weeks.PMID:36411567 | DOI:10.2174/1570159X21666221118164612 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 22, 2022 Category: Drugs & Pharmacology Authors: Yiguo Tang Yulu Wu Xiaojing Li QinJian Hao Wei Deng Weihua Yue Hao Yan Yamin Zhang Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fude Yang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Lingjiang Li Chuanyue Wang Xi Source Type: research
Early Efficacy of Antipsychotic Medications at Week 2 Predicts Subsequent Responses at Week 6 in a Large-scale Randomized Controlled Trial
CONCLUSIONS: It is robust enough to clinically predict treatment responses to antipsychotics at week 6 using the reduction rate of PANSS total score and symptom relief at week 2. Psychiatric clinicians had better determine whether to switch the treatment plan by the first 2 weeks.PMID:36411567 | DOI:10.2174/1570159X21666221118164612 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 22, 2022 Category: Drugs & Pharmacology Authors: Yiguo Tang Yulu Wu Xiaojing Li QinJian Hao Wei Deng Weihua Yue Hao Yan Yamin Zhang Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fude Yang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Lingjiang Li Chuanyue Wang Xi Source Type: research
Antipsychotics and Medical Comorbidity: A Retrospective Study in an Urban Outpatient Psychiatry Clinic
This study suggests that research is warranted to study the association between antipsychotics, medical comorbidity, and psychotic symptom burden.PMID:36355255 | DOI:10.1007/s10597-022-01045-2 (Source: Community Mental Health Journal)
Source: Community Mental Health Journal - November 10, 2022 Category: Psychiatry Authors: Catherine W Bennett Lauren Gensler David R Goldsmith Source Type: research
