Agonistic properties of a series of psychotropic drugs at 5-HT < sub > 1A < /sub > receptors in rat and human brain membranes determined by [ < sup > 35 < /sup > S]GTP γS binding assay
CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.PMID:36637685 | DOI:10.1007/s43440-023-00448-6
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Yuji Odagaki Masaki Mikami Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Dasiel Oscar Borroto-Escuela Kjell Fuxe Source Type: research
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