Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 13, 2019 Category: ENT & OMF Authors: Dr. Kelcie Barnts, Dr. Celeste Abraham, Dr. Yi-Shing Lisa Cheng Tags: #124 Source Type: research

Gradient Boosting Decision Tree-Based Method for Predicting Interactions Between Target Genes and Drugs
Determining the target genes that interact with drugs—drug–target interactions—plays an important role in drug discovery. Identification of drug–target interactions through biological experiments is time consuming, laborious, and costly. Therefore, using computational approaches to predict candidate targets is a good way to reduce the cost of wet-lab experiments. However, the known interactions (positive samples) and the unknown interactions (negative samples) display a serious class imbalance, which has an adverse effect on the accuracy of the prediction results. To mitigate the impact of class imb...
Source: Frontiers in Genetics - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

A Compilation of Serum Concentrations of 12 Antipsychotic Drugs in a Therapeutic Drug Monitoring Setting
Conclusions: For each antipsychotic drug, the results presented can serve as a reference tool for pharmacokinetic interpretation of the individual patient's serum drug level. The compiled serum concentrations and the C/D ratios can support the physician's decision when individualizing dosing and determining treatment strategies for a specific patient. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 14, 2019 Category: Drugs & Pharmacology Tags: Original Article Source Type: research

Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons.
Abstract Second-generation antipsychotics (SGAs) are recommended for maintenance treatment in schizophrenia. However, comparative long-term effectiveness among SGAs is unclear. Here we provide a systematic review and meta-analysis of randomized trials lasting ≥⃒6 months comparing SGAs head-to-head in schizophrenia and related disorders. The primary outcome was all-cause discontinuation. Secondary outcomes included efficacy and tolerability, i.e., psychopathology, inefficacy-related and intolerability-related discontinuation, relapse, hospitalization, remission, functioning, quality of life, and adverse events...
Source: World Psychiatry - May 8, 2019 Category: Psychiatry Authors: Kishimoto T, Hagi K, Nitta M, Kane JM, Correll CU Tags: World Psychiatry Source Type: research

Transcriptome Changes in Relation to Manic Episode
We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - May 1, 2019 Category: Psychiatry Source Type: research

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
New England Journal of Medicine,Volume 380, Issue 18, Page 1778-1780, May 2019. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - May 1, 2019 Category: Internal Medicine Source Type: research

No Reduction in Delirium with the Use of Haloperidol or Ziprasidone in Critically Ill Patients.
PMID: 30932453 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - April 1, 2019 Category: Primary Care Authors: Shrikant Kulkarni N Tags: Am Fam Physician Source Type: research

Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation
Publication date: April 2019Source: Annals of Emergency Medicine, Volume 73, Issue 4Author(s): Scott Zeller, Michael Wilson, Kimberly Nordstrom (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - March 22, 2019 Category: Emergency Medicine Source Type: research

Clinical Outcomes in Patients Taking Inhaled Loxapine, Haloperidol, or Ziprasidone in the Emergency Department
Objectives Our objective was to compare outcomes of discharge disposition, need for additional medications, and restraint use for patients who received inhaled loxapine compared with patients receiving traditional antipsychotic drugs in the emergency department (ED). Methods A retrospective chart review was conducted on all patients who presented to the ED with agitation and received antipsychotic therapy, including loxapine, ziprasidone, or haloperidol from December 1, 2014, through October 31, 2016. Results The mean time from physician assignment to medical clearance was 7.9 hours for patients treated with inhale...
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Twenty-Four–Hour Measures of Heart Rate–Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment
Purpose/Background Prolonged ventricular repolarization, measured by heart rate–corrected QT interval (QTc) prolongation, might be a biomarker for risk of torsade de pointes (TdP) and sudden cardiac death. However, the predictive value of QTc has been challenged, and a component of QTc, peak-to-end of the T-wave (Tpe), and a high Tpe/QT ratio might be superior biomarkers because they better reflect increased transmural dispersion of ventricular myocyte repolarization, which can lead to TDP. The purpose of this pilot study was to provide the first measurements of heart rate, QTc, Tpe, Tpe/QTc, and their variability ...
Source: Journal of Clinical Psychopharmacology - February 26, 2019 Category: Psychiatry Tags: Original Contribution Source Type: research

Ziprasidone Augmentation of SSRI Antidepressants in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Pilot Study of Augmentation Therapy
Conclusions Although no significant differences were noted in efficacy or safety measures between ziprasidone and placebo in this pilot study, the small sample size prevents definitive conclusions. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - February 26, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Antipsychotic Use During Pregnancy and the Risk of Gestational Diabetes Mellitus: A Systematic Review
This study aimed to review the current literature examining a potential relationship between the use of antipsychotic drugs during pregnancy and gestational diabetes mellitus (GDM). Methods PubMed was searched for English language reports between January 1, 1996, and March 31, 2018, by using combinations of the following key words: antipsychotics, pregnancy, FGAs, SGAs, GDM, obstetric outcomes, pregnancy outcomes, obstetric complications, maternal complications, clozapine, olanzapine, risperidone, aripiprazole, amisulpirde, ziprasidone, quetiapine, haloperidol, chlorpromazine, zuclopenthixol, and flupenthixol. Studies b...
Source: Journal of Clinical Psychopharmacology - February 26, 2019 Category: Psychiatry Tags: Review Article Source Type: research

Correction to: The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone
After publication of our article it came to our attention that it contains a number of errors with regard to the citations. The details are provided below: (Source: Inflammation)
Source: Inflammation - February 15, 2019 Category: Allergy & Immunology Source Type: research

Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites.
Abstract Novel diethanolamine-grafted high-methoxyl pectin (DGP)-arabic gum (AG) modified montmorillonite (MMT) composites were developed for intragastric ziprasidone HCl (ZIP) delivery by combining floating and mucoadhesion mechanisms. The ZIP-loaded clay-biopolymer matrices were accomplished by ionotropic gelation protocol utilizing zinc acetate in the presence or absence of covalent crosslinker, glutaraldehyde (GA). Various formulations exhibited excellent drug entrapment efficiency (DEE, %) and sustained drug release profiles, which were influenced by the polymer-blend (DGP:AG) ratios, reinforcing filler (MMT)...
Source: International Journal of Biological Macromolecules - January 29, 2019 Category: Biochemistry Authors: Bera H, Abbasi YF, Yoke FF, Seng PM, Kakoti BB, Ahmmed SKM, Bhatnagar P Tags: Int J Biol Macromol Source Type: research

Effects of Atypical Antipsychotic Treatment and Resistant Starch Supplementation on Gut Microbiome Composition in a Cohort of Patients with Bipolar Disorder or Schizophrenia
ConclusionThese data suggest that AAP treatment is associated with measurable differences in gut microbiota, particularly in female AAP ‐treated patients in whom reduced species richness was observed. Additionally, variable microbiome responses to resistant starch supplementation were seen, with a significant increase in starch degraders.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - January 8, 2019 Category: Drugs & Pharmacology Authors: Stephanie A. Flowers, Nielson T. Baxter, Kristen M. Ward, A. Zarina Kraal, Melvin G. McInnis, Thomas M. Schmidt, Vicki L. Ellingrod Tags: Original Research Article Source Type: research

A Combined Utilization of Plasdone-S630 and HPMCAS-HF in Ziprasidone Hydrochloride Solid Dispersion by Hot-Melt Extrusion to Enhance the Oral Bioavailability and No Food Effect.
Abstract The purpose of this study was to research a novel combination of Plasdone-S630 and HPMCAS-HF as hot-melt carrier used in ziprasidone hydrochloride for enhanced oral bioavailability and dismissed food effect. Ziprasidone hydrochloride solid dispersion (ZH-SD) was prepared by hot-melt extrusion technique, and its optimized formulation was selected by the central composite design (CCD), which was characterized for powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FTIR), in vitro dissolution study, and stability study. Finally, the in vivo study in fasted/fed state was carried out in b...
Source: AAPS PharmSciTech - January 2, 2019 Category: Drugs & Pharmacology Authors: Xue X, Chen G, Xu X, Wang J, Wang J, Ren L Tags: AAPS PharmSciTech Source Type: research

The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone
AbstractZiprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. This is the case of guaran á xanthine-catechin chemical matrix (XC-Mix) that presents caffeine, theobromine, and catechin. Thein vitro protocols using murine RAW 264.7 cell macrophages were ZIP-exposure in culture me...
Source: Inflammation - December 14, 2018 Category: Allergy & Immunology Source Type: research

Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome
We report a 29-year-old man with history of obsessive compulsive disorder and Tourette syndrome who presented with 2 months of worsening dyspnea 3 weeks after starting ziprasidone 40 mg daily that required mechanical ventilation. A year before, after an increased risperidone dose from 0.5 to 1 mg daily, he had developed proximal muscle weakness that spontaneously improved 2 months after discontinuation of risperidone. On this admission, his creatine kinase (CK) was 3318 units/L, and ziprasidone was discontinued. He fully recovered 2 months after discontinuation of ziprasidone, and his CK was 62 units/L. Genetic testing for...
Source: Journal of Clinical Neuromuscular Disease - December 1, 2018 Category: Neurology Tags: Short Report Source Type: research

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone
Conclusion: Based on the findings, a proper risk assessment strategy needs to be factored (i.e., perpetrator and/or victim drug) to overcome any imminent risk of potential clinical drug-drug interaction when sulfoxide/sulfone metabolite(s) generating drugs are coadministered in therapy. (Source: Drug Metabolism Letters)
Source: Drug Metabolism Letters - November 22, 2018 Category: Drugs & Pharmacology Source Type: research

Gene Risk Scores May Predict Antipsychotic Response in Patients With First-Episode Psychosis
Astudy published today inAJP in Advance suggests that calculating the polygenic risk score (PRS) of a patient with first-episode psychosis can offer clues as to whether he or she will respond to antipsychotics. A PRS involves adding up the total number of genetic variants associated with schizophrenia risk in an individual ’s DNA.“Polygenic risk scores represent the combined effects of many thousands of genetic variants across the entire genome, and better represent the very complex genetic nature of schizophrenia,” said lead study author Jian-Ping Zhang, M.D., Ph.D., an assistant professor at the Feinste...
Source: Psychiatr News - November 5, 2018 Category: Psychiatry Tags: antipsychotic biomarker first-episode psychosis genetic risk genetic variant polygenic risk score precision medicine schizophrenia Source Type: research

Knowledge of the Pharmacology of Antidepressants and Antipsychotics Yields Results Comparable With Pharmacogenetic Testing
Several companies offer pharmacogenetic testing for psychiatry on the basis of the claim that the outcome of drug selection is better when guided by such testing than when such testing is not used. This column examines the results of the GeneSight Psychotropic Test which groups various antidepressants and antipsychotics into 3 bins: green (“use as directed”), yellow (“use with caution”), and red (“use with increased caution and more frequent monitoring”). The authors examined how frequently the same drugs appeared in these different bins in 19 patients. They found that of the 22 antidepr...
Source: Journal of Psychiatric Practice - November 1, 2018 Category: Psychiatry Tags: COLUMNS Source Type: research

Haloperidol, Ziprasidone Found Ineffective in Treating Patients With Delirium in the ICU
Neither haloperidol nor ziprasidone, medications commonly used to treat psychosis, had any benefit over placebo in treating patients for delirium in the intensive care unit (ICU), according to astudy published Monday in theNew England Journal of Medicine.“For more than 40 years, intravenous antipsychotic medications have been used to treat delirium in hospitalized patients,” wrote E.W. Ely, M.D., of the Vanderbilt University Medical Center and colleagues. “In this double-blind, randomized, placebo-controlled trial of intravenous antipsychotic medications for the treatment of delirium in the ICU, there was...
Source: Psychiatr News - October 23, 2018 Category: Psychiatry Tags: delirium haloperidol New England Journal of Medicine ziprasidone Source Type: research

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
New England Journal of Medicine, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 22, 2018 Category: Internal Medicine Authors: Timothy D. Girard Matthew C. Exline Shannon S. Carson Catherine L. Hough Peter Rock Michelle N. Gong Ivor S. Douglas Atul Malhotra Robert L. Owens Daniel J. Feinstein Babar Khan Margaret A. Pisani Robert C. Hyzy Gregory A. Schmidt William D. Schweickert R Source Type: research

Hyponatremia in Association With Second-Generation Antipsychotics: A Systematic Review of Case Reports.
Authors: Ali SN, Bazzano LA Abstract Background: Hyponatremia is generally defined as a serum sodium level
Source: Ochsner Journal - October 4, 2018 Category: General Medicine Tags: Ochsner J Source Type: research

Comparing Schizophrenia Patients With a Predicted High/Low Risk of Nonresponse Receiving Treatment with Ziprasidone and Haloperidol: A Randomized-Controlled Study
Discussion An alarmingly high number of patients were at high risk of nonresponse to antipsychotic treatment. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 20, 2018 Category: Psychiatry Authors: Schennach, Rebecca Riedel, Michael Spellmann, Ilja Musil, Richard Obermeier, Michael J äger, Markus Bottlender, Roland Schmauss, Max Laux, Gerd M öller, Hans-Jürgen Tags: Original Paper Source Type: research

Ultra-performance liquid chromatography tandem mass-spectrometry (UHPLC-MS/MS) for the rapid, simultaneous analysis of ziprasidone and its impurities.
Abstract Separation and characterization of the unknown degradation product of second generation antipsychotic drug ziprasidone was essential for defining genotoxic potential of the compound. The aim of this study was to develop simple UHPLC method coupled with tandem mass spectrometry (MS/MS) for chemical characterization of unknown degradant, separation and quantification of ziprasidone and its five main impurities (I-V) in raw material and pharmaceuticals. Chromatographic conditions were optimized by experimental design. The MS/MS fragmentation conditions were optimized individually for each compound in order t...
Source: Biomedical Chromatography : BMC - September 14, 2018 Category: Biomedical Science Authors: Čarapić M, Nikolic K, Marković B, Petković M, Pavlovic M, Agbaba D Tags: Biomed Chromatogr Source Type: research

The effects of illness severity, cognition, and estimated antipsychotic dopamine receptor occupancy on insight into the illness in schizophrenia: An analysis of clinical antipsychotics trials of intervention effectiveness (CATIE) data
ConclusionsConsistent with previous literature, our results suggest that IIA is a function of illness severity in adult patients with schizophrenia. Future studies should explore whether D2R occupancy mediates the relationships between IIA and illness severity, and IIA and cognitive dysfunction, in late-life schizophrenia (i.e. ≥60 years) given the effects of aging on cognition, IIA, and antipsychotic sensitivity. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 31, 2018 Category: Psychiatry Source Type: research

Among the Severely Mentally Ill, Who Responds to Ziprasidone?
This study examines some differences in response to ziprasidone, which has been shown to be effective, with a better metabolic side effect profile, but was little used in New York State Hospitals. The aim was to study state hospital patients switched to ziprasidone. The results led to questions about different responses in different groups. Subjects from state hospitals who needed a change of antipsychotic participated in this open-label, 8-week trial of up to 240-mg ziprasidone. Analyses included comparisons of the very different results from two sites. Of the 36 study subjects, 12 terminated early. The 17 outpatients fro...
Source: Clinical Schizophrenia and Related Psychoses - July 25, 2018 Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research

Dose reduction of high-dose first-generation antipsychotics or switch to ziprasidone in long-stay patients with schizophrenia: A 1-year double-blind randomized clinical trial
Long-stay patients with severe schizophrenia are frequently treated with high doses of first-generation antipsychotics (FGA). Dose reduction or switching to ziprasidone may reduce the severity of negative symptoms and side effects.We investigated in a randomized double-blind trial whether a dose-reduction strategy to achieve an adequate dose of a FGA (5  mg/day haloperidol equivalents, n = 24) or switching to ziprasidone (160 mg/day, n = 24) in treatment resistant patients would decrease negative symptoms after 1 year of treatment. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 16, 2018 Category: Psychiatry & Psychology Authors: Jan P.A.M. Bogers, Peter F.J. Schulte, Theo G. Broekman, Peter Moleman, Lieuwe de Haan Source Type: research

Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department
Publication date: Available online 7 June 2018Source: Annals of Emergency MedicineAuthor(s): Lauren R. Klein, Brian E. Driver, James R. Miner, Marc L. Martel, Michelle Hessel, Jacob D. Collins, Gabriella B. Horton, Erik Fagerstrom, Rajesh Satpathy, Jon B. ColeStudy objectiveAgitation in the emergency department (ED) can pose a threat to patient and provider safety; therefore, treatment is indicated. The purpose of this study is to compare haloperidol, olanzapine, midazolam, and ziprasidone to treat agitation.MethodsThis was a prospective observational study of consecutive patients receiving intramuscular medication to trea...
Source: Annals of Emergency Medicine - July 10, 2018 Category: Emergency Medicine Source Type: research

Ziprasidone for the Treatment of Stuttering
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Clinical Pharmacokinetics of Atypical Antipsychotics: An Update
AbstractTherapeutic drug monitoring studies have generally concentrated on controlling compliance and avoiding side effects by maintaining long-term exposure to minimally effective blood concentrations. The rationale for using therapeutic drug monitoring in relation to second-generation antipsychotics is still being discussed at least with regard to the real clinical utility, but there is evidence that it can improve efficacy, especially when patients do not respond or develop side effects using therapeutic doses. Furthermore, drug plasma concentration determinations can be of some utility in medico-legal problems. This re...
Source: Clinical Pharmacokinetics - June 19, 2018 Category: Drugs & Pharmacology Source Type: research

Nanocrystal-Silica-Lipid Hybrid Particles for the Improved Oral Delivery of Ziprasidone in vitro.
Abstract The synergistic effect of nanosizing and lipid-based drug delivery systems (LBDDS) was explored to enhance formulation drug loading levels and improve drug solubilisation in the gastrointestinal environment. A novel formulation combining drug nanocrystals and silica-lipid hybrid (SLH) microparticles as a solid-state LBDDS was developed for the challenging poorly water-soluble drug, ziprasidone. A ziprasidone nanosuspension was fabricated via high-pressure homogenisation, achieving a mean particle size of 280 nm. In vitro dissolution studies revealed the nanosuspension to exhibit a significant 2.4-fold inc...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 29, 2018 Category: Drugs & Pharmacology Authors: Meola TR, Dening TJ, Prestidge CA Tags: Eur J Pharm Biopharm Source Type: research

Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes.
CONCLUSIONS: Compared with women who discontinued use of an atypical antipsychotic medication before the start of pregnancy, women who continued treatment with olanzapine or quetiapine had an increased risk of gestational diabetes that may be explained by the metabolic effects associated with these two drugs. PMID: 29730938 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 7, 2018 Category: Psychiatry Authors: Park Y, Hernandez-Diaz S, Bateman BT, Cohen JM, Desai RJ, Patorno E, Glynn RJ, Cohen LS, Mogun H, Huybrechts KF Tags: Am J Psychiatry Source Type: research

A Systematic Review of Atypical Antipsychotics in Chronic Pain Management: Olanzapine Demonstrates Potential in Central Sensitization, Fibromyalgia, and Headache/Migraine
Conclusions: Few studies have been conducted to evaluate the analgesic effects of AAs. The collective findings of multiple studies evaluating olanzapine in pain syndromes suggest a high, yet preliminary level of evidence of efficacy, warranting prospective studies in various pain syndrome contexts. Pharmacological mechanisms of AA action are elaborated, and the findings of this review are discussed. Risk and benefits of using AAs in chronic pain are described, and investigational implications and future directions are explored. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 4, 2018 Category: Anesthesiology Tags: Review Articles Source Type: research

c-Fos expression in the hypothalamic paraventricular nucleus after a single treatment with a typical haloperidol and nine atypical antipsychotics: a pilot study.
CONCLUSIONS: The present pilot study revealed c-Fos expression increase predominantly in the PVN medial parvocellular subdivision neurons by action of only several sorts of antipsychotics tested indicating that this structure of the brain does not represent a common extra-striatal target area for all antipsychotics. PMID: 29715183 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review
AbstractThe issue of antipsychotic treatment during pregnancy is subject to substantial uncertainty and some controversy among healthcare providers, specifically pertaining to second-generation antipsychotics (SGAs) that are subject to a large gap in safety data during pregnancy compared with antidepressants. The amount of safety data for the use of SGAs during pregnancy is rapidly increasing, thus constantly changing the level of evidence. We performed a clinically focused review on the safety of SGA during pregnancy. Twenty-three studies provided various pregnancy outcomes for 14,382 pregnant women exposed to an SGA duri...
Source: CNS Drugs - April 10, 2018 Category: Neurology Source Type: research

Hospitalization Risk in Bipolar Disorder Patients Treated with Lurasidone versus Other Atypical Antipsychotics.
CONCLUSIONS: In this claims database analysis, lurasidone-treated patients with bipolar disorder had a significantly lower risk of psychiatric hospitalization compared to quetiapine, olanzapine, and risperidone, but not aripiprazole or ziprasidone. Lurasidone-treated patients had a significantly lower risk of all-cause hospitalization compared to quetiapine, olanzapine, risperidone, and aripiprazole, but not ziprasidone. PMID: 29625538 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

T5. lurasidone and risk for metabolic syndrome in patients with schizophrenia: a comprehensive database analysis
AbstractBackgroundPatients with schizophrenia are at increased risk for developing metabolic syndrome, with an estimated prevalence of approximately 35 –50% (Correll et al. Psychiatr Serv 2010;61:892–98; Vancampfort et al. World Psychiatry 2015;14:339–47). Treatment with atypical antipsychotic medications have been shown to increase rates of metabolic syndrome, with differences observed among antipsychotic agents, most notably in propensity f or weight gain: higher for olanzapine, clozapine, and iloperidone; intermediate for quetiapine, risperidone, and paliperidone; and lower for amisulpride, aripiprazol...
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

T223. real world effectiveness of antipsychotic drugs in patients with schizophrenia: a 10-years retrospective study
The objective of present study is to determine which antipsychotic medication is highly effective in a real-world clinical setting considering adjuvant pharmacotherapy over a 10-year follow-up period.MethodsA total of 2300 patients with schizophrenia were recruited at the Seoul National University Hospital, and participants received amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone for up to 10-years. Time-to-discontinuation of antipsychotic medications was analyzed using Kaplan-Meier survival analyses. Group differences were compared using log-rank tests.Resu...
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

F53. dose reduction of high-dose first-generation antipsychotics or switch to ziprasidone in long-stay patients with schizophrenia: a 1-year double-blind randomized clinical trial
DiscussionIn long-stay patients with severe schizophrenia, reducing high doses of FGA to a dose equivalent of 5 mg/day haloperidol or switching to ziprasidone did not improve negative symptoms. Reducing antipsychotic doses was feasible in most patients, although the risk of relapse is substantial. Neither FGA dose reduction nor ziprasidone seems an adequate alternative to clozapine for treatment-resistant schizophrenia. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

F229. the biological underpinnings of treatment response in delusional disorder: a systematic review of qualitative evidence-to-date
DiscussionThe strongests biological contributors for treatment response in delusional disorder seem to be those implicating monoaminergic systems, particularly dopamine and serotonergic neurotransmitters. Although the low level of evidence, the serotonergic dysfunction may be associated with response rates, especially in delusional disorder somatic type. The link between genetic variants of dopamine receptors and neuroimaging findings in delusional disorder may open new avenues for the search of the biological underpinnings of treatment response. The evidence for an integrated model involving dopamine and serotonin systems...
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

F234. typical and atypical antipsychotics ’ d2r affinity and doses influences postsynaptic density by modulating the spatial expression of homer1a a gene highly implicated in synaptic plasticity and psychosis
AbstractBackgroundPost-synaptic density (PSD) is an ultra-specialized structure of excitatory synapses composed by a large variety of molecules (scaffolding proteins, glutamate receptors, cytoskeleton proteins). PSD has been implicated in synaptic plasticity, memory formation and in the pathophysiology of psychiatric disorders by extensive GWA studies. The immediate early gene Homer1a is part of this complex molecular machinery for signaling transmission and its expression is modulated by antipsychotics (APDs). Here we show a comparative analysis of Homer1a expression data by first and second-generation APDs, in order to c...
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

O7.3. dose-response meta-analysis to identify the optimum and equivalent doses of antipsychotic drugs for schizophrenia
DiscussionFrom a conceptual point of view, dose-response meta-analysis is the most appropriate method to identify maximally effective doses and equivalent doses. The results of this meta-analysis will be compared with other published methods to define dose-response, in particular the minimum-effective dose method, the classical mean dose method, the daily-defined-doses (DDD) method and expert consensus methods. The results of this analysis are likely to provide information with impact for treatment decisions. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research

Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder.
Abstract BACKGROUND: In 2012, the Food and Drug Administration issued Drug Safety Communications on several drugs associated with QT prolongation and fatal ventricular arrhythmias. Among these was citalopram, a selective serotonin reuptake inhibitor (SSRI) approved for depression and commonly used for posttraumatic stress disorder (PTSD). Evaluation of the risk for QT prolongation among other psychotropic drugs for individuals with PTSD remains limited. OBJECTIVE: Explore psychotropic drugs associated with QT prolongation among veterans with PTSD. METHODS: Patients in the Veterans Health Administration i...
Source: The Annals of Pharmacotherapy - April 1, 2018 Category: Drugs & Pharmacology Authors: Stock EM, Zeber JE, McNeal CJ, Banchs JE, Copeland LA Tags: Ann Pharmacother Source Type: research

Comparative Efficacy and Safety of Antipsychotic Drugs for Tic Disorders: A Systematic Review and Bayesian Network Meta-Analysis
Conclusions Atypical antipsychotics (risperidone and aripiprazole) appear to be the most robust evidence-based options for the treatment of TDs. Quetiapine may be a promising therapy. Ziprasidone and olanzapine are also effective, but the evidence is lacking. Further high-quality directly comparing different pharmacological treatment studies are justified. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 5, 2018 Category: Psychiatry Authors: Yang, Chunsong Hao, Zilong Zhang, Ling-Li Zhu, Cai-Rong Zhu, Ping Guo, Qin Tags: Review Source Type: research

Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study
Publication date: Available online 1 March 2018 Source:The Lancet Psychiatry Author(s): Hao Yu, Hao Yan, Lifang Wang, Jun Li, Liwen Tan, Wei Deng, Qi Chen, Guigang Yang, Fuquan Zhang, Tianlan Lu, Jianli Yang, Keqing Li, Luxian Lv, Qingrong Tan, Hongyan Zhang, Xiao Xiao, Ming Li, Xin Ma, Fude Yang, Lingjiang Li, Chuanyue Wang, Tao Li, Dai Zhang, Weihua Yue Background Antipsychotic drugs improve schizophrenia symptoms and reduce the frequency of relapse, but treatment response is highly variable. Little is known about the genetic factors associated with treatment response. We did a genome-wide association study of antipsych...
Source: The Lancet Psychiatry - March 2, 2018 Category: Psychiatry Source Type: research