Unraveling the Influence of Age, IQ, Education, and Negative Symptoms
on Neurocognitive Performance in Schizophrenia: A Conditional Inference Tree
Analysis
Conclusions These findings emphasize the multifaceted nature of
neurocognitive functioning in patients with schizophrenia, with the
PANSS-negative score being an important predictor. This gives rise to a role in
addressing negative symptoms as a therapeutic objective for enhancing cognitive
impairments in these patients. Further research must examine nonlinear
relationships among various moderating factors identified in this work,
especially the role of D2 occupancy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJourna...
Source: Pharmacopsychiatry - February 22, 2024 Category: Psychiatry Authors: Hart, Xenia M. Mitsukura, Yasue Bies, Robert R. Uchida, Hiroyuki Tags: Pharmacopsychiatry Women Source Type: research
Withdrawal syndrome after antipsychotics discontinuation: an analysis of the WHO database of spontaneous reports (Vigibase) between 2000 and 2022
ConclusionOur results suggest that there might be a risk difference for WDS between antipsychotics. Tiotixene, pimozide and quetiapine were associated with a higher risk of reporting a WDS whereas this risk was lower with chlorpromazine, clozapine and fluphenazine. We could not address the issue of withdrawal psychosis, withdrawal dyskinesia, rebound psychosis or supersensitivity psychosis due to the lack of specific WHO medDRA coded terms to identify potential cases. (Source: Psychopharmacology)
Source: Psychopharmacology - February 20, 2024 Category: Psychiatry Source Type: research
Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients
Translational Psychiatry, Published online: 08 January 2024; doi:10.1038/s41398-023-02686-xOlanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients (Source: Translational Psychiatry)
Source: Translational Psychiatry - January 8, 2024 Category: Psychiatry Authors: Marco Pozzi Chiara Vantaggiato Francesca Brivio Genny Orso Maria Teresa Bassi Source Type: research
Antipsychotics and the risk of diabetes and death among adults with serious mental illnesses
CONCLUSIONS: Haloperidol's, olanzapine's, and risperidone's lower diabetes risks relative to aripiprazole were not robust in sensitivity analyses but quetiapine's higher mortality risk proved robust. Findings expand the evidence on antipsychotics' risks, suggesting a need for caution in the use of quetiapine among individuals with SMI.PMID:37753625 | DOI:10.1017/S0033291723001502 (Source: Psychological Medicine)
Source: Psychological Medicine - September 27, 2023 Category: Psychiatry Authors: Jason Poulos Sharon-Lise T Normand Katya Zelevinsky John W Newcomer Denis Agniel Haley K Abing Marcela Horvitz-Lennon Source Type: research
An Exploratory Study of the Impact of COVID-19 Vaccine Spontaneous Reporting on Masking Signal Detection in EudraVigilance
ConclusionsWe demonstrated five cases of masking and one case of false-positive association due to the influence of COVID-19 vaccine spontaneous reporting on the ROR. This suggests that the high number of adverse drug reaction reports for COVID-19 vaccines in EudraVigilance has the potential to affect routine statistical signal detection activities. The impact of COVID-19 vaccine ADR reports on current signal detection practices requires further evaluation and solutions to tackle masking issues in EudraVigilance may need to be developed. (Source: Drug Safety)
Source: Drug Safety - September 14, 2023 Category: Drugs & Pharmacology Source Type: research
Continuous-Flow Regioselective Reductive Alkylation of Oxindole with Alcohols and Aldehydes in a Fast and Economical Manner
Synthesis DOI: 10.1055/a-2122-4080 Oxindole is a widely used scaffold in drug discovery, which can be found in several marketed drugs, among them sunitinib and ziprasidone. Thus, the derivatization of oxindole is of considerable current interest. The extreme reaction conditions (high temperature, high pressure) described in the literature for the batchwise regioselective multistep 3-alkylation of oxindole with alcohols in the presence of Raney nickel motivated us to develop a robust, time- and cost-efficient continuous-flow variant for this reaction. In addition, the continuous-flow technology was also extended to the redu...
Source: Synthesis - August 15, 2023 Category: Chemistry Authors: M ándoki, András Orsy, Gy örgy P ászti, Zoltán Porcs-Makkay, M árta Bogd án, Dóra Simig, Gyula M ándity, István Volk, Bal ázs Tags: paper Source Type: research
Cognitive Effects of Lurasidone and Cariprazine: A Mini Systematic Review
CONCLUSION: The cognitive effect of lurasidone could be explained by its potent antagonism at the 5- HT7 receptors combined with partial agonism at 5-HT1A receptors. The pro-cognitive effect of cariprazine is probably explained by its very high affinity for D3 receptors. Head-to-head studies com- paring lurasidone and cariprazine are needed to establish the "first-choice" treatment for cognitive dys- function associated with schizophrenia.PMID:37519001 | DOI:10.2174/1570159X21666230727140843 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Miriam Olivola Nicola Bassetti Serena Parente Vincenzo Arienti Serena Chiara Civardi Pietro Alessandro Topa Natascia Brondino Source Type: research
Cognitive Effects of Lurasidone and Cariprazine: A Mini Systematic Review
CONCLUSION: The cognitive effect of lurasidone could be explained by its potent antagonism at the 5- HT7 receptors combined with partial agonism at 5-HT1A receptors. The pro-cognitive effect of cariprazine is probably explained by its very high affinity for D3 receptors. Head-to-head studies com- paring lurasidone and cariprazine are needed to establish the "first-choice" treatment for cognitive dys- function associated with schizophrenia.PMID:37519001 | DOI:10.2174/1570159X21666230727140843 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Miriam Olivola Nicola Bassetti Serena Parente Vincenzo Arienti Serena Chiara Civardi Pietro Alessandro Topa Natascia Brondino Source Type: research
Atypical antipsychotics attenuate MK801-induced social withdrawal and hyperlocomotion in the RHA rat model of schizophrenia-relevant features
ConclusionsThese results seem to be in line with previous studies with the NMDAR-antagonist model and add face (MK801-induced social withdrawal and hyperactivity) and predictive (attenuation of MK801-induced effects by atypical antipsychotics) validity to the RHA rat strain as a model of schizophrenia-relevant features. (Source: Psychopharmacology)
Source: Psychopharmacology - July 13, 2023 Category: Psychiatry Source Type: research
Real-world effectiveness of pharmacological treatments for bipolar disorder: register-based national cohort study
CONCLUSIONS: Lithium and certain LAI antipsychotics were associated with lowest risks of psychiatric admission. Lithium was the only treatment associated with decreased risk of both psychiatric and somatic admissions.PMID:37395140 | DOI:10.1192/bjp.2023.75 (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - July 3, 2023 Category: Psychiatry Authors: Markku L ähteenvuo Tapio Palj ärvi Antti Tanskanen Heidi Taipale Jari Tiihonen Source Type: research
Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis
DiscussionInsomnia, sedation, and somnolence were the most frequent adverse effects on sleep among the different antipsychotics administered. The evidence shows that chlorpromazine, clozapine, flupentixol, perospirone, and amisulpride had favorable safety profiles. In contrast, ziprasidone, perphenazine, haloperidol, and risperidone were the least safe for sleep.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42017078052, identifier: PROSPERO 2017 CRD42017078052. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - June 27, 2023 Category: Psychiatry Source Type: research
