Risankizumab as a Therapeutic Approach for Recalcitrant Pyoderma Gangrenosum
Adv Skin Wound Care. 2024 May 1;37(5):276-279. doi: 10.1097/ASW.0000000000000129.ABSTRACTPyoderma gangrenosum (PG) is a neutrophilic dermatosis that is challenging to diagnose and treat. Clinicians frequently use fast-acting corticosteroids, which are subsequently combined with slower-acting immunosuppressants to progressively taper the corticosteroid dosage. Current research is focused on the use of monoclonal antibodies (mAbs) directed against target molecules involved in the pathogenesis of PG. However, available data on their efficacy are based on sporadic case reports and clinical experiences, so the authors aimed to ...
Source: Adv Data - April 22, 2024 Category: Epidemiology Authors: Alessandra Michelucci Flavia Manzo Margiotta Giammarco Granieri Giorgia Salvia Cristian Fidanzi Matteo Bevilacqua Salvatore Panduri Marco Romanelli Valentina Dini Source Type: research
Hyaluronic Acid Based Adipose Tissue-Derived Extracellular Matrix Scaffold in Wound Healing: Histological and Immunohistochemical Study
Conclusion:ECM-HA sheets offer a promising approach for wound management, combining the benefits of adECM and HA. They present improved stability and cost-effectiveness while promoting essential aspects of wound healing such as angiogenesis and collagen formation. This study underscores the therapeutic potential of ECM-HA sheets in clinical applications aimed at facilitating wound repair. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 22, 2024 Category: Biotechnology Source Type: research
Multifunctional Self-Healing Carbon Dot-Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization
Biomacromolecules. 2024 Apr 17. doi: 10.1021/acs.biomac.4c00313. Online ahead of print.ABSTRACTBioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained -NH2, -OH, -COOH, and, most importantly, -CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile ...
Source: Biomacromolecules - April 18, 2024 Category: Biochemistry Authors: Maansi Aggarwal Harekrishna Panigrahi Dinesh Kumar Kotnees Prolay Das Source Type: research
Multifunctional Self-Healing Carbon Dot-Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization
Biomacromolecules. 2024 Apr 17. doi: 10.1021/acs.biomac.4c00313. Online ahead of print.ABSTRACTBioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained -NH2, -OH, -COOH, and, most importantly, -CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile ...
Source: Biomacromolecules - April 18, 2024 Category: Biochemistry Authors: Maansi Aggarwal Harekrishna Panigrahi Dinesh Kumar Kotnees Prolay Das Source Type: research
Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles
Adv Colloid Interface Sci. 2024 Apr 16;327:103155. doi: 10.1016/j.cis.2024.103155. Online ahead of print.ABSTRACTWound healing is a complex physiological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Therefore, there is an urgent need for suitable wound dressings for effective and systematical wound management. Polypeptide-based hydrogel bio-adhesives offer unique advantages and are ideal candidates. However, comprehensive reviews on polypeptide-based hydrogel bio-adhesives for wound healing are still lacking. In this review, the physiological mechanisms and evaluation parameters of woun...
Source: Advances in Colloid and Interface Science - April 17, 2024 Category: Chemistry Authors: Jiahao Yang Zhengyue Wang Xiaoben Liang Wenyi Wang Shige Wang Source Type: research
Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles
Adv Colloid Interface Sci. 2024 Apr 16;327:103155. doi: 10.1016/j.cis.2024.103155. Online ahead of print.ABSTRACTWound healing is a complex physiological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Therefore, there is an urgent need for suitable wound dressings for effective and systematical wound management. Polypeptide-based hydrogel bio-adhesives offer unique advantages and are ideal candidates. However, comprehensive reviews on polypeptide-based hydrogel bio-adhesives for wound healing are still lacking. In this review, the physiological mechanisms and evaluation parameters of woun...
Source: Advances in Colloid and Interface Science - April 17, 2024 Category: Chemistry Authors: Jiahao Yang Zhengyue Wang Xiaoben Liang Wenyi Wang Shige Wang Source Type: research
Burden of dog bite injuries and wound management practices to prevent rabies among dog owners
CONCLUSION: The incidence of dog bites among the dog owners was high. The rabies pre- and post-exposure prophylaxis practices adopted by the participants were found to be inadequate.PMID:38605805 | PMC:PMC11006032 | DOI:10.4103/jfmpc.jfmpc_768_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Dhawani Julka Amir M Khan Nitu Kumari Ujjwal Soni Source Type: research
Burden of dog bite injuries and wound management practices to prevent rabies among dog owners
CONCLUSION: The incidence of dog bites among the dog owners was high. The rabies pre- and post-exposure prophylaxis practices adopted by the participants were found to be inadequate.PMID:38605805 | PMC:PMC11006032 | DOI:10.4103/jfmpc.jfmpc_768_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Dhawani Julka Amir M Khan Nitu Kumari Ujjwal Soni Source Type: research
Burden of dog bite injuries and wound management practices to prevent rabies among dog owners
CONCLUSION: The incidence of dog bites among the dog owners was high. The rabies pre- and post-exposure prophylaxis practices adopted by the participants were found to be inadequate.PMID:38605805 | PMC:PMC11006032 | DOI:10.4103/jfmpc.jfmpc_768_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Dhawani Julka Amir M Khan Nitu Kumari Ujjwal Soni Source Type: research
Copper Ion ‐Inspired Dual Controllable Drug Release Hydrogels for Wound Management: Driven by Hydrogen Bonds
CG-Cu2+0.5-DG10/MAP possessed proper mechanical strength predominantly driven by strong CG-H2O-Cu2+ hydrogen bonding interaction, which is the main force regulating the sustained release of Cu2+. It exhibited excellent self-healing, injectability, antibacterial, anti-inflammatory activities with high biocompatibility. Moreocer, CG-Cu2+0.5-DG10/MAP expedited wound closure onS. aureus-infected full-thickness skin wound model and lowered necrosis progression to the unburned interspaces on a rat burn model. AbstractBacterial infections and inflammation progression yield huge trouble for the management of serious skin wounds an...
Source: Small - April 9, 2024 Category: Nanotechnology Authors: Zhuxian Wang,
Jun Liu,
Yixin Zheng,
Bohai Zhang,
Yi Hu,
Yufan Wu,
Yamei Li,
Li Liu,
Hongxia Zhu,
Qiang Liu,
Bin Yang Tags: Research Article Source Type: research
Skin Grafting for Dermatologists: Past, Present, and Future
ConclusionSkin grafting is a complex procedure that requires careful planning and postoperative care. Success depends on factors like the type of graft, wound management, and overall health of the patient. Skin grafting has evolved with advancements in surgery, anesthesia, and wound care and remains a crucial technique for restoring function and appearance. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - April 9, 2024 Category: Dermatology Source Type: research
Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large ( ≥ 3 cm) gastric submucosal tumors
CONCLUSION: Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture, especially for large (≥ 3 cm) EFTR wounds in SMTs.PMID:38577185 | PMC:PMC10989488 | DOI:10.3748/wjg.v30.i9.1143 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Shan-Shan Wang Meng-Yao Ji Xu Huang Yan-Xia Li Shi-Jie Yu Yu Zhao Lei Shen Source Type: research
Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large ( ≥ 3 cm) gastric submucosal tumors
CONCLUSION: Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture, especially for large (≥ 3 cm) EFTR wounds in SMTs.PMID:38577185 | PMC:PMC10989488 | DOI:10.3748/wjg.v30.i9.1143 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Shan-Shan Wang Meng-Yao Ji Xu Huang Yan-Xia Li Shi-Jie Yu Yu Zhao Lei Shen Source Type: research
Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large ( ≥ 3 cm) gastric submucosal tumors
CONCLUSION: Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture, especially for large (≥ 3 cm) EFTR wounds in SMTs.PMID:38577185 | PMC:PMC10989488 | DOI:10.3748/wjg.v30.i9.1143 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Shan-Shan Wang Meng-Yao Ji Xu Huang Yan-Xia Li Shi-Jie Yu Yu Zhao Lei Shen Source Type: research
