Copper Ion ‐Inspired Dual Controllable Drug Release Hydrogels for Wound Management: Driven by Hydrogen Bonds

CG-Cu2+0.5-DG10/MAP possessed proper mechanical strength predominantly driven by strong CG-H2O-Cu2+ hydrogen bonding interaction, which is the main force regulating the sustained release of Cu2+. It exhibited excellent self-healing, injectability, antibacterial, anti-inflammatory activities with high biocompatibility. Moreocer, CG-Cu2+0.5-DG10/MAP expedited wound closure onS. aureus-infected full-thickness skin wound model and lowered necrosis progression to the unburned interspaces on a rat burn model. AbstractBacterial infections and inflammation progression yield huge trouble for the management of serious skin wounds and burns. However, some hydrogel dressing exhibit poor wound-healing capabilities. Additionally, little information is given on the molecular theory of hydrogel gelation mechanisms and drug release performance from drug-polymer network in the water environment. Herein, cationic guar gum (CG) is first mixed with dipotassium glycyrrhizinate (DG), and then crosslinked Cu2+ to strengthen the mechanical strength followed by encapsulating mussel adhesive protein (MAP) as composite dressings. Intriguingly, CG-Cu2+0.5-DG10 possessed proper rheological properties and mechanical strength predominantly driven by strong CG-H2O-Cu2+ and Cu2+-CG hydrogen bonding interaction. Weak DG-CG hydrogen bonding only controlled DG release in the initial 4 h, while strong hydrogen bonding is the main force regulating the sustained release of Cu2+ within 48 h. The incorporation of MAP...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research