Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing
Background: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be a promising drug candidate for wound treatment and that RADA16-I can serve as a release system for bioactive peptides in wound healing. Based on that, in this work, we designed a new self-assembling hydrogel RADA-PDGF2, connecting both peptides by a sequence spe...
Source: Frontiers in Pharmacology - November 28, 2023 Category: Drugs & Pharmacology Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Self-assembled and dynamic bond crosslinked herb-polysaccharide hydrogel with anti-inflammation and pro-angiogenesis effects for burn wound healing
Colloids Surf B Biointerfaces. 2023 Nov 7;233:113639. doi: 10.1016/j.colsurfb.2023.113639. Online ahead of print.ABSTRACTExcessive inflammation and defective angiogenesis can affect burn wound healing. Recently, naturally derived substances with anti-inflammatory and proangiogenic properties have attracted public attention. The design and fabrication of naturally derived substance-based bioactive hydrogels as wound dressings are of interest and important for regulating the complex microenvironment of the wound bed. Herein, we developed a hydrogel by self-assembling a natural herb (glycyrrhizic acid, GA) dynamic Schiff base...
Source: Colloids and Surfaces - November 11, 2023 Category: Biotechnology Authors: Hongfu Wu Tao Wang Yinru Liang Liji Chen Ziyi Li Source Type: research
Self-assembled and dynamic bond crosslinked herb-polysaccharide hydrogel with anti-inflammation and pro-angiogenesis effects for burn wound healing
Colloids Surf B Biointerfaces. 2023 Nov 7;233:113639. doi: 10.1016/j.colsurfb.2023.113639. Online ahead of print.ABSTRACTExcessive inflammation and defective angiogenesis can affect burn wound healing. Recently, naturally derived substances with anti-inflammatory and proangiogenic properties have attracted public attention. The design and fabrication of naturally derived substance-based bioactive hydrogels as wound dressings are of interest and important for regulating the complex microenvironment of the wound bed. Herein, we developed a hydrogel by self-assembling a natural herb (glycyrrhizic acid, GA) dynamic Schiff base...
Source: Colloids and Surfaces - November 11, 2023 Category: Biotechnology Authors: Hongfu Wu Tao Wang Yinru Liang Liji Chen Ziyi Li Source Type: research
