The Use of Timolol for Wound Healing—A Review
AbstractPurpose of ReviewIn recent years, drug repurposing has gained traction as a method to accelerate the availability of effective treatments. This review focuses on timolol, originally a topical non-selective β-adrenergic antagonist used for increased intraocular pressure and glaucoma, and its emerging role in the wound healing landscape—a field that has been lacking in effective treatments for decades.Recent FindingsPreclinical and clinical studies have highlighted timolol ’s promise as a therapeutic option in wound healing. Its benefits are attributed to various mechanisms including improved re-epithelial...
Source: Current Dermatology Reports - February 22, 2024 Category: Dermatology Source Type: research
Comparative analysis of electrochemical and optical sensors for detection of chronic wounds biomarkers: A review
Biosens Bioelectron. 2024 Feb 15;251:116095. doi: 10.1016/j.bios.2024.116095. Online ahead of print.ABSTRACTChronic wounds (CW) present a significant healthcare challenge due to their prolonged healing time and associated complications. To effectively treat these wounds and prevent further deterioration, monitoring their healing progress is crucial. Traditional wound assessment methods relying on visual inspection and subjective evaluation are prone to inter-observer variability. Biomarkers play a critical role in objectively evaluating wound status and predicting healing outcomes, providing quantitative measures of wound ...
Source: Biosensors and Bioelectronics - February 21, 2024 Category: Biotechnology Authors: F átima A R Mota Marieta L C Passos Jo ão L M Santos M L úcia M F S Saraiva Source Type: research
Mussel-inspired near-infrared light-responsive gelatin-based hydrogels for enhancing MRSA-infected wound healing
Int J Biol Macromol. 2024 Feb 13:129887. doi: 10.1016/j.ijbiomac.2024.129887. Online ahead of print.ABSTRACTInfected wound management is a great challenge to healthcare, especially in emergencies such as accidents or battlefields. Hydrogels as wound dressings can replace or supplement traditional wound treatment strategies, such as bandages or sutures. It is significant to develop novel hydrogel-based wound dressings with simple operation, inexpensive, easy debridement, effective antibacterial, biocompatibility, etc. Here, we designed a novel gelatin-based hydrogel wound dressing Gel-TA-Fe3+. The hydrogels used tannic-modi...
Source: International Journal of Biological Macromolecules - February 21, 2024 Category: Biochemistry Authors: Jian Yang Haojie Yu Li Wang Xiaowei Liu Yudi Huang Yichuan Hong Shuning Ren Source Type: research
Comparative analysis of electrochemical and optical sensors for detection of chronic wounds biomarkers: A review
Biosens Bioelectron. 2024 Feb 15;251:116095. doi: 10.1016/j.bios.2024.116095. Online ahead of print.ABSTRACTChronic wounds (CW) present a significant healthcare challenge due to their prolonged healing time and associated complications. To effectively treat these wounds and prevent further deterioration, monitoring their healing progress is crucial. Traditional wound assessment methods relying on visual inspection and subjective evaluation are prone to inter-observer variability. Biomarkers play a critical role in objectively evaluating wound status and predicting healing outcomes, providing quantitative measures of wound ...
Source: Biosensors and Bioelectronics - February 21, 2024 Category: Biotechnology Authors: F átima A R Mota Marieta L C Passos Jo ão L M Santos M L úcia M F S Saraiva Source Type: research
Molecules, Vol. 29, Pages 883: Biodegradable Polymers in Veterinary Medicine & mdash;A Review
Molecules, Vol. 29, Pages 883: Biodegradable Polymers in Veterinary Medicine—A Review
Molecules doi: 10.3390/molecules29040883
Authors:
Magdalena Broda
Daniel J. Yelle
Katarzyna Serwańska-Leja
During the past two decades, tremendous progress has been made in the development of biodegradable polymeric materials for various industrial applications, including human and veterinary medicine. They are promising alternatives to commonly used non-degradable polymers to combat the global plastic waste crisis. Among biodegradable polymers used, or potentially applicable to, veterinary medicine are natural poly...
Source: Molecules - February 17, 2024 Category: Chemistry Authors: Magdalena Broda Daniel J. Yelle Katarzyna Serwa ńska-Leja Tags: Review Source Type: research
Effect of the home care model in orthopedic wounds management
CONCLUSIONS: Home care for patients with orthopedic wounds can significantly reduce the time spent on medical treatment. Moreover, improve patients' moods and trust and satisfaction with medical staff in a certain extent. However, better service often means more economic cost.PMID:38361869 | PMC:PMC10866231 | DOI:10.4103/jfmpc.jfmpc_876_23 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Xinhuan Lei Jie Xiang Xiaoxiao Chen Wenjun Pan Source Type: research
Effect of the home care model in orthopedic wounds management
CONCLUSIONS: Home care for patients with orthopedic wounds can significantly reduce the time spent on medical treatment. Moreover, improve patients' moods and trust and satisfaction with medical staff in a certain extent. However, better service often means more economic cost.PMID:38361869 | PMC:PMC10866231 | DOI:10.4103/jfmpc.jfmpc_876_23 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Xinhuan Lei Jie Xiang Xiaoxiao Chen Wenjun Pan Source Type: research
Scalp wound management: a narrative review from a neurosurgical perspective
Journal of Wound Care,Volume 33, Issue 2, Page 127-135, February 2024. (Source: Journal of Wound Care)
Source: Journal of Wound Care - February 8, 2024 Category: Nursing Authors: Santiago Cardona Carolina Hern ández Maria Paz Boh órquez-Tarazona Andr és M Rubiano Diana Marcela S ánchez Parra Source Type: research
Tumescent Technique for Split-thickness Skin Graft Donor Sites: A Systematic Review of Randomized Controlled Trials
Split-thickness skin grafting (STSG) is widely used for reconstructive wound management. The purpose of this review was to use level I evidence to determine if tumescent techniques were safe and effective compared to other interventions for STSG donor sites. It was hypothesized that tumescent techniques were both safe and effective for STSG donor sites. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - February 2, 2024 Category: Cosmetic Surgery Authors: Angela Ash, Madison Brune, Thomas D. Willson, Stephen H. Colbert, Kevin M. Klifto Source Type: research
Impact of ultra-pulse carbon dioxide laser on the treatment of chronic refractory ulcer with bone exposure
This study aimed to investigate the impact of ultra-pulse carbon dioxide laser on treating chronic refractory ulcers with bone exposure. (Source: Surgery)
Source: Surgery - January 27, 2024 Category: Surgery Authors: Bo Jiang, Xiyang Li, Rui Tang, Lei Mei, Danyu Zheng, Xinli Tian Source Type: research
Assessing the Influence of Rural Residence and Economic Distress on Lower Extremity Risk Stratification among Diabetic Foot Ulcer Patients: Utilization of the Wound, Ischemia, foot Infection (WIfI) Classification System
Diabetic foot ulcers (DFUs) are major sequelae of uncontrolled diabetes that have a high risk of adverse outcomes, including hospital admission, infection, lower extremity amputation, and mortality. The burden of DFUs disproportionately impacts rural and economically distressed patients due to a lack of access to, and affordability of diabetic guideline-directed care and specialized multidisciplinary wound care facilities for proper wound management. Lack of access to standardized care may result in a more advanced stage of a wound at presentation, leading to poorer health outcomes. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - January 18, 2024 Category: Surgery Authors: Jordan Tasman, Devin J. Clegg, Colten Carver, Saahit Adabala, Ryan M. Buckley, Mitchell H. Goldman, Patricia N.E. Roberson Source Type: research
Sensors, Vol. 24, Pages 524: A Custom-Tailored Multichannel Pressure Monitoring System Designed for Experimental Surgical Model of Abdominal Compartment Syndrome
Norbert Nemeth
In experimental medicine, a wide variety of sensory measurements are used. One of these is real-time precision pressure measurement. For comparative studies of the complex pathophysiology and surgical management of abdominal compartment syndrome, a multichannel pressure measurement system is essential. An important aspect is that this multichannel pressure measurement system should be able to monitor the pressure conditions in different tissue layers, and compartments, under different settings. We created a 12-channel positive–negative sensor system for simultaneous detection of pressure c...
Source: Sensors - January 15, 2024 Category: Biotechnology Authors: Zoltan Attila Godo Katalin Peto Klaudia Balog Adam Deak Erzsebet Vanyolos Laszlo Adam Fazekas Zsolt Szentkereszty Norbert Nemeth Tags: Article Source Type: research
Chitosan-based films filled with nanoencapsulated essential oil: Physical-chemical characterization and enhanced wound healing activity
In this study, we produced nanoemulsions (NE) loaded with SFO, characterized them, and evaluated their tissue repairing properties. Dynamic light scattering (DLS) analysis confirmed the formation of a nanoemulsion with a droplet size of 21.12 ± 2.31 nm and a polydispersity index (PdI) of 0.159, indicating good stability for up to 90 days. To investigate the potential wound healing effects, SFO-loaded NE were applied on male C57BL/6 mice for seven consecutive days, producing a significantly higher wound closure efficiency (p < 0.05) for the group treated with SFO-loaded NE compared to the control group treated with the ...
Source: International Journal of Biological Macromolecules - January 4, 2024 Category: Biochemistry Authors: Adriana de Oliveira E Silva Guerrero Talita Nascimento da Silva Stephani Araujo Cardoso Flavia Fernandes Ferreira da Silva Beatriz Ferreira de Carvalho Patricio Raquel Pires Gon çalves Gilberto Weissmuller Marcia Cury El-Cheikh Katia Carneiro Tha ís Nog Source Type: research
Chitosan-based films filled with nanoencapsulated essential oil: Physical-chemical characterization and enhanced wound healing activity
In this study, we produced nanoemulsions (NE) loaded with SFO, characterized them, and evaluated their tissue repairing properties. Dynamic light scattering (DLS) analysis confirmed the formation of a nanoemulsion with a droplet size of 21.12 ± 2.31 nm and a polydispersity index (PdI) of 0.159, indicating good stability for up to 90 days. To investigate the potential wound healing effects, SFO-loaded NE were applied on male C57BL/6 mice for seven consecutive days, producing a significantly higher wound closure efficiency (p < 0.05) for the group treated with SFO-loaded NE compared to the control group treated with the ...
Source: International Journal of Biological Macromolecules - January 4, 2024 Category: Biochemistry Authors: Adriana de Oliveira E Silva Guerrero Talita Nascimento da Silva Stephani Araujo Cardoso Flavia Fernandes Ferreira da Silva Beatriz Ferreira de Carvalho Patricio Raquel Pires Gon çalves Gilberto Weissmuller Marcia Cury El-Cheikh Katia Carneiro Tha ís Nog Source Type: research
