Mitochondrial Dysfunction in Cancer Chemoprevention by Phytochemicals from Dietary and Medicinal Plants
Publication date: Available online 17 November 2016 Source:Seminars in Cancer Biology Author(s): Anuradha Sehrawat, Ruchi Roy, Subrata K. Pore, Eun-Ryeong Hahm, Suman K. Samanta, Krishna B. Singh, Su-Hyeong Kim, Kamayani Singh, Shivendra V. Singh Cancer chemoprevention, a scientific term coined by Dr. Sporn in the late seventies, implies use of natural or synthetic chemicals to block, delay or reverse carcinogenesis. Phytochemicals derived from edible and medicinal plants have been studied rather extensively for cancer chemoprevention using preclinical models in the past few decades. Nevertheless, some of these ...
Source: Seminars in Cancer Biology - November 16, 2016 Category: Cancer & Oncology Source Type: research
In vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activity
Abstract
Inhibition of enzymes involved in carbohydrate and lipids metabolism is an important strategy against type 2 diabetes and obesity, by suppressing dietary sugar and fat absorption. This work reports, for the first time, the in vitro inhibition of α‐glucosidase, α‐amylase and lipase by watercress juice (WJ). Juice was analyzed for qualitative and quantitative composition and in vitro antioxidant activities. Several components were identified, namely hydroxycinnamic acids, flavonols, and other minor water‐soluble phytochemicals. Quantitative data revealed a dimer of caffeoylmalic acid (0.73 mg mL−1 of jui...
Source: Journal of Food Biochemistry - July 31, 2016 Category: Food Science Authors: V ítor Spínola, Joana Pinto, Paula C. Castilho Tags: Full Article Source Type: research
Myrosinase Compatible Simultaneous Determination of Glucosinolates and Allyl Isothiocyanate by Capillary Electrophoresis Micellar Electrokinetic Chromatography (CE‐MEKC)
ConclusionsThe presented capillary electrophoresis method requires a minimal amount of sample and contains only a few sample preparation steps, and can be used in several applications (glucosinolate determination, myrosinase activity measurement, isothiocyanate release estimation). Copyright © 2016 John Wiley & Sons, Ltd. (Source: Phytochemical Analysis)
Source: Phytochemical Analysis - June 16, 2016 Category: Biochemistry Authors: Sándor Gonda, Attila Kiss‐Szikszai, Zsolt Szűcs, Nhat Minh Nguyen, Gábor Vasas Tags: Research article Source Type: research
Effects of domestic processing methods on the phytochemical content of watercress (Nasturtium officinale)
Publication date: 1 December 2016 Source:Food Chemistry, Volume 212 Author(s): Natasa Giallourou, Maria Jose Oruna-Concha, Niamh Harbourne The impact of conventional cooking and processing methods on total phenols, antioxidant activity, carotenoids and glucosinolates of watercress was evaluated. Boiling significantly decreases phenolic content, antioxidant activity and recoverable glucosinolates, however it increases the carotenoid concentrations of watercress as compared to the raw vegetable. Cooking by microwaving and steaming maintains the majority of phytochemicals in comparison to the fresh material, suggest...
Source: Food Chemistry - June 8, 2016 Category: Food Science Source Type: research
Uranium accumulation in aquatic macrophytes in an uraniferous region: Relevance to natural attenuation.
Abstract
Phytoremediation potential of uranium (U) was investigated by submerged, free-floating and rooted emergent native aquatic macrophytes inhabiting along the streams of Horta da Vilariça, a uraniferous geochemical region of NE Portugal. The work has been undertaken with the following objectives: (i) to relate the U concentrations in water-sediment-plant system; and (ii) to identify the potentialities of aquatic plants to remediate U-contaminated waters based on accumulation pattern. A total of 25 plant species culminating 233 samples was collected from 15 study points along with surface water and co...
Source: Chemosphere - May 6, 2016 Category: Chemistry Authors: Cordeiro C, Favas PJ, Pratas J, Sarkar SK, Venkatachalam P Tags: Chemosphere Source Type: research
Clinical Trial of 2-Phenethyl Isothiocyanate
2-Phenethyl isothiocyanate (PEITC), a natural product found as a conjugate in watercress and other cruciferous vegetables, is an inhibitor of the metabolic activation and lung carcinogenicity of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in F344 rats and A/J mice. We carried out a clinical trial to determine whether PEITC also inhibits the metabolic activation of NNK in smokers. Cigarette smokers were recruited and asked to smoke cigarettes containing deuterium-labeled [pyridine-D4]NNK for an acclimation period of at least 1 week. Then subjects were randomly assigned to one of two arms: PEI...
Source: Cancer Prevention Research - April 30, 2016 Category: Cancer & Oncology Authors: Yuan, J.-M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D., Hecht, S. S. Tags: Research Articles Source Type: research
Usefulness of different vascular plant species for passive biomonitoring of Mediterranean rivers.
Abstract
Choosing native vascular plants as nutrient and toxic element accumulators for passive biomonitoring of urban river quality is not an easy task in Mediterranean rivers, due to the particular climate determining high variations in river hydrology. To identify potential biomonitors for this area, the roots of seven species (Angelica sylvestris, Apium nodiflorum, Tradescantia fluminensis, Nasturtium officinale, Persicaria lapathifolia, Arctium lappa, Typha latifolia), growing in seven sites along the River Irno (Southern Italy), were collected in July 2010 and analyzed regarding their capability to a...
Source: Environmental Science and Pollution Research International - April 3, 2016 Category: Environmental Health Authors: Baldantoni D, Alfani A Tags: Environ Sci Pollut Res Int Source Type: research
Unveiling the first indole-fused thiazepine: structure, synthesis and biosynthesis of cyclonasturlexin, a remarkable cruciferous phytoalexin
Chem. Commun., 2016, Accepted ManuscriptDOI: 10.1039/C6CC02108E, CommunicationM Soledade C Pedras, Q. Huy ToAs a mechanism of defense against pathogens and other types of stress, watercress plants produce a variety of elicited chemical defenses generally known as phytoalexins. Herein the chemical structure, synthesis,...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - March 30, 2016 Category: Chemistry Authors: M Soledade C Pedras Source Type: research
Total phenolic and vitamin C content and antiradical activity evaluation of traditionally consumed wild edible vegetables from Turkey
Title: Total phenolic and vitamin C content and antiradical activity evaluation of traditionally consumed wild edible vegetables from Turkey
Authors: Samancioglu, A; Sat, IG; Yildirim, E; Ercisli, S; Jurikova, T; Mlcek, J
Abstract: Cultivation of
wild edible vegetables, traditionally used as food, should increase in agriculture,
as they have valuable nutritional content and contain bioactive compounds. Notably,
wild edible green vegetables play a significant role in conventional
diets. They are abundant in phenols and show
high antiradical activity. The aim of this study was to determine the DPPH radical-scavenging
...
Source: Indian Journal of Traditional Knowledge - March 29, 2016 Category: Science Authors: search Source Type: research
Suitability of gamma irradiation for preserving fresh-cut watercress quality during cold storage
Publication date: 1 September 2016 Source:Food Chemistry, Volume 206 Author(s): José Pinela, João C.M. Barreira, Lillian Barros, Sandra Cabo Verde, Amilcar L. Antonio, Ana Maria Carvalho, M. Beatriz P.P. Oliveira, Isabel C.F.R. Ferreira The suitability of gamma irradiation (1, 2 and 5kGy) for preserving quality parameters of fresh-cut watercress (Nasturtium officinale R. Br.) during storage at 4±1°C for 7d was investigated. The storage time decreased the protein content and the main carbohydrates, and increased the levels of malic and fumaric acids, sucrose and mono- and polyunsaturated fatty acids ...
Source: Food Chemistry - March 21, 2016 Category: Food Science Source Type: research
Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1.
In conclusion, we demonstrate for the first time that CDDP resistance is partially associated with Mcl-1 in BTC cells and we identify a novel mechanism that PEITC can enhance CDDP-induced apoptosis via glutathionylation-dependent degradation of Mcl-1. Hence, our results provide support that dietary intake of watercress may help reverse CDDP resistance in BTC patients.
PMID: 26848531 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - February 9, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Micron-size superparamagnetic iron-oxides watercress with unique MRI properties
Publication date: Available online 25 December 2015 Source:Materials Chemistry and Physics Author(s): Wei Liu, Ji Ma, Kezheng Chen In this work, 10-μm-sized superparamagnetic Fe3O4@(α, γ)−Fe2O3 watercress was synthesized by a one-step solvothermal method. Meanwhile, the other two kinds of micron-size hierarchical structures were also obtained by solely altering Fe2+/urea molar ratio in the same solvothermal procedure. It was found that the nuance of reaction parameters during synthesis can greatly alter the morphologies and structures of the obtained products, but it cannot alter their unique superparamagnet...
Source: Materials Chemistry and Physics - December 26, 2015 Category: Materials Science Source Type: research
Nutritional Composition, Antioxidant and Antimicrobial Activities of Selected Wild Edible Plants
This study determines the nutritional composition and antioxidant and antimicrobial activities of wild plants available in Pakistan. Eight wild plant species, such as Chenopodium murale, Eruca sativa, Goldbachia laevigata, Malcolmia africana, Malva neglecta, Medicago polymorpha, Melilotus officinalis and Nasturtium officinale, were collected from their natural habitat and analyzed. Proximate analysis of plants showed good amount of fibers and proteins in M. neglecta and M. officinalis. Among the minerals, calcium and potassium were predominantly present in all plants. The total antioxidant and free radical‐scavenging...
Source: Journal of Food Biochemistry - September 18, 2015 Category: Food Science Authors: Hamayun Khan, Syed Aleem Jan, Mehwish Javed, Rabia Shaheen, Zahid Khan, Aftab Ahmad, Sher Zaman Safi, Muhammad Imran Tags: Full Article Source Type: research
Abstract 1910: Reactivation of p53R175 mutant by dietary phenethyl isothiocyanate (PEITC) impairs tumor growth in vivo
In this study we demonstrated that PEITC can reactivate p53R175 mutant protein and inhibit tumor growth in a mutant p53R175H -dependent manner.PEITC displayed a 175 allele preference of inhibition of cell proliferation as compared to other hotspot mutants as detected by WST-1 assay and induced apoptosis in a p53R175 mutant -dependent manner. Immunofluorescence and co-immunoprecipitation assay on PEITC treated p53R175 cells using conformation-specific antibodies (PAB1620 and PAB240) showed restoration of the “WT-like” conformation to p53 mutant. Reactivation of the WT like functions to the p53R175 mutant was established...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Aggarwal, M., Sinclair, E., Jacobs, A., Fu, Y., Dyba, M., Wang, X., Cruz, I. M., Berry, D., Bhaskar, K., Mueller, S. C., Avantaggiati, M. L., Chung, F.-L. Tags: Prevention Research Source Type: research
Abstract 1906: CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells
This study demonstrates, for the first time, that cancer chemopreventive ITCs suppress CXCR4 expression in prostate cancer cells in vitro as well as in vivo. These results suggest that CXCR4 downregulation may be an important pharmacodynamic biomarker of cancer chemopreventative ITCs in prostate adenocarcinoma.Citation Format: Ali I. Amjad, Kozue Sakao, Avani R. Vyas, Sreenivasa R. Chinni, Rahul Parikh, Shivendra V. Singh. CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Amjad, A. I., Sakao, K., Vyas, A. R., Chinni, S. R., Parikh, R., Singh, S. V. Tags: Prevention Research Source Type: research
