10160 Sentinel Lymph Node Biopsy with Technetium-99m and Fluorescence Indocyanine Green for Vulvar Cancer
Effectiveness and safety of Indocyanine green (ICG) for sentinel lymph node biopsy on vulvar cancer. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 27, 2023 Category: OBGYN Authors: IC Bernal, E Yoon, MI Newman, J Cardenas Source Type: research
NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma
In conclusion, NOTCH1 and PIK3CA mutations are detectable in a substantial proportion of vulvSCC and are related to HPV infection and more aggressive tumor behaviour.PMID:37839360 | DOI:10.1016/j.prp.2023.154877 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - October 15, 2023 Category: Pathology Authors: M Choschzick C Stergiou A Gut M Zoche J S Ross H Moch Source Type: research
Safety and efficacy of topical artesunate for the treatment of vulvar intraepithelial neoplasia 2/3
CONCLUSIONS: Topical artesunate for treatment of high-grade VIN shows high tolerability, low toxicity and evidence for clinical response in this initial small series. The safety and observed responses support further study in a Phase II trial.PMID:37839312 | DOI:10.1016/j.ygyno.2023.10.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 15, 2023 Category: Cancer & Oncology Authors: Chad M Michener Stephanie Ricci Mariam AlHilli Lindsey Beffa Robert Debernardo Steven E Waggoner Jennifer Brainard Mihaela Plesa Jerome L Belinson Cornelia L Trimble Source Type: research
NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma
In conclusion, NOTCH1 and PIK3CA mutations are detectable in a substantial proportion of vulvSCC and are related to HPV infection and more aggressive tumor behaviour.PMID:37839360 | DOI:10.1016/j.prp.2023.154877 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - October 15, 2023 Category: Pathology Authors: M Choschzick C Stergiou A Gut M Zoche J S Ross H Moch Source Type: research
Safety and efficacy of topical artesunate for the treatment of vulvar intraepithelial neoplasia 2/3
CONCLUSIONS: Topical artesunate for treatment of high-grade VIN shows high tolerability, low toxicity and evidence for clinical response in this initial small series. The safety and observed responses support further study in a Phase II trial.PMID:37839312 | DOI:10.1016/j.ygyno.2023.10.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 15, 2023 Category: Cancer & Oncology Authors: Chad M Michener Stephanie Ricci Mariam AlHilli Lindsey Beffa Robert Debernardo Steven E Waggoner Jennifer Brainard Mihaela Plesa Jerome L Belinson Cornelia L Trimble Source Type: research
Digital droplet PCR-based quantification of ccfHPV-DNA as liquid biopsy in HPV-driven cervical and vulvar cancer
CONCLUSIONS: Therapy monitoring with determination of ccfHPV-DNA by ddPCR with a small amount of plasma reflects response to therapy and appears feasible for patients in advanced cancer stages of cervical and vulvar cancer. This promising tool should be examined as marker of therapy monitoring in particular in novel HPV-directed therapies.PMID:37452202 | DOI:10.1007/s00432-023-05077-3 (Source: Cell Research)
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Fabinshy Thangarajah Jana Busshoff Janina Salamon Marie-Sandrine Pruss Caroline Lenz Bernd Morgenstern Martin Hellmich Hans Anton Schl ößer Maximilian Lenz Christian Domr öse Michael R Mallmann Peter Mallmann Jonathan Wei ß Fabian Franzen Sabine Merke Source Type: research
Digital droplet PCR-based quantification of ccfHPV-DNA as liquid biopsy in HPV-driven cervical and vulvar cancer
ConclusionsTherapy monitoring with determination of ccfHPV-DNA by ddPCR with a small amount of plasma reflects response to therapy and appears feasible for patients in advanced cancer stages of cervical and vulvar cancer. This promising tool should be examined as marker of therapy monitoring in particular in novel HPV-directed therapies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 14, 2023 Category: Cancer & Oncology Source Type: research
Trends in the use of indocyanine green for sentinel lymph node mapping in vulvar cancer
The status of the inguinofemoral lymph nodes confers important prognostic and treatment information in cases of vulvar cancer. This status was historically evaluated using surgical exploration with en block resection of the lymphatic tissue in the inguinofemoral region. More recently, prospective trials have demonstrated the feasibility and oncologic safety of sentinel lymph node (SLN) biopsy for vulvar cancer,1,2 and there has been a gradual increase in the performance of SLN biopsies in the United States. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - July 14, 2023 Category: OBGYN Authors: Koji Matsuo, Ling Chen, Katina Robison, Maximilian Klar, Lynda D. Roman, Jason D. Wright Tags: Research Letter Source Type: research
Real-time fluorescent ICG and 99m Tc nanocolloid tracer navigation in bilateral sentinel lymph node mapping of vulvar cancer
The effectiveness of sentinel lymph node (SLN) biopsy has been validated by two prospective trials, GROINS VI and GOG 1731-2. According to ESGO guideline in patients with unifocal tumors with a diameter of (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - July 12, 2023 Category: OBGYN Authors: Antonino Ditto, Stefano Ferla, Fabio Martinelli, Giorgio Bogani, Umberto Leone Roberti Maggiore, Francesco Raspagliesi Tags: Video Article Source Type: research
Real-time Fluorescent ICG and 99m-Tc Nanocolloid Tracer Navigation in Bilateral Sentinel Lymph Node Mapping of Vulvar Cancer
The effectiveness of sentinel lymph node (SLN) biopsy has been validated by 2 prospective trials, GROINS VI and GOG 173 [1,2]. According to the European Society of Gynaecological Oncology guideline in patients with unifocal tumors with a diameter of (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - July 12, 2023 Category: OBGYN Authors: Antonino Ditto, Stefano Ferla, Fabio Martinelli, Giorgio Bogani, Umberto Leone Roberti Maggiore, Francesco Raspagliesi Tags: Video Article Source Type: research
Extramammary Paget Disease: a Therapeutic Challenge, for a Rare Entity
AbstractPurpose of ReviewExtramammary Paget disease (EMPD) is a rare entity which is more frequently localized at the vulva, though it only accounts for 1 –2% of vulvar neoplasms. It is a primary cutaneous adenocarcinoma whose cell of origin is still a matter of controversy: it can either arise from apocrine/eccrine glands or from stem cells. The diagnosis demands a biopsy and entails a histopathological analysis by which cells show similar characte ristics as breast Paget disease.Recent FindingsTreatment approach can entail surgery, radiotherapy, photodynamic therapy, systemic chemotherapy, and topical chemotherapy. For...
Source: Current Oncology Reports - July 8, 2023 Category: Cancer & Oncology Source Type: research
LASER treatment in gynaecology -A randomized controlled trial in women with symptomatic lichen sclerosus
CONCLUSION: Laser treatment with the microablative CO2 laser leads to a significant improvement for symptoms of LS. A higher dosage of laser radiation shows no benefit concerning the symptoms. We have not observed any serious adverse events during this study.PMID:37352640 | DOI:10.1016/j.ejogrb.2023.06.003 (Source: Reproductive Biology)
Source: Reproductive Biology - June 23, 2023 Category: Reproduction Medicine Authors: Elke Krause Stephanie Neumann Marina Maier Sara Imboden Laura Knabben Michael D Mueller Annette Kuhn Source Type: research
LASER treatment in gynaecology -A randomized controlled trial in women with symptomatic lichen sclerosus
CONCLUSION: Laser treatment with the microablative CO2 laser leads to a significant improvement for symptoms of LS. A higher dosage of laser radiation shows no benefit concerning the symptoms. We have not observed any serious adverse events during this study.PMID:37352640 | DOI:10.1016/j.ejogrb.2023.06.003 (Source: Reproductive Biology)
Source: Reproductive Biology - June 23, 2023 Category: Reproduction Medicine Authors: Elke Krause Stephanie Neumann Marina Maier Sara Imboden Laura Knabben Michael D Mueller Annette Kuhn Source Type: research
LASER treatment in gynaecology -A randomized controlled trial in women with symptomatic lichen sclerosus
CONCLUSION: Laser treatment with the microablative CO2 laser leads to a significant improvement for symptoms of LS. A higher dosage of laser radiation shows no benefit concerning the symptoms. We have not observed any serious adverse events during this study.PMID:37352640 | DOI:10.1016/j.ejogrb.2023.06.003 (Source: Reproductive Biology)
Source: Reproductive Biology - June 23, 2023 Category: Reproduction Medicine Authors: Elke Krause Stephanie Neumann Marina Maier Sara Imboden Laura Knabben Michael D Mueller Annette Kuhn Source Type: research
Feasibility of intraoperative injection of radioactive tracer and blue dye for sentinel lymph node biopsy in vulvar cancer
CONCLUSION: In this cohort, the overall success rate of sentinel lymph node mapping and biopsy was 86.5%. The high rate of successful sentinel lymph node mapping supports the use of intraoperative radiotracer and blue dye injection by trained providers.PMID:37321154 | DOI:10.1016/j.ygyno.2023.05.067 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - June 15, 2023 Category: Cancer & Oncology Authors: Alison A Garrett Jason Ricciuti Susan M Lang Mary E Burriss Margaret Flanigan Emily O'Brien Casey Hay Jamie Lesnock Jessica L Berger Sarah E Taylor Source Type: research
