Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts
Vulvodynia is a debilitating condition characterized by painful sensitivity to touch and pressure in the vestibular tissue surrounding the vaginal opening. It is often a “diagnosis of exclusion” of idiopathic pain made in the absence of visible inflammation or injury. However, the association between increased vulvodynia risk and a history of yeast infections and skin allergies has led researchers to explore whether immune mechanisms of dysregulated inflammation might underlie the pathophysiology of this chronic pain condition. Here we synthesize epidemiological investigations, clinical biopsies and primary cell c...
Source: Frontiers in cellular and infection microbiology - June 8, 2023 Category: Microbiology Source Type: research
LASER Treatment in Gynaecology –A randomized controlled trial in women with symptomatic Lichen Sclerosus
Objective: Aim of our study was to evaluate the therapeutic effect of laser treatment in vulvar lichen sclerosus, mainly the reduction of existing symptoms as itching, burning and pain. We asked about the different outcome by using different application dosesStudy Design: We conducted a prospective randomized double-blind dose-controlled trial in our dysplasia unit specializing vulvar disorders. 67patients with active LS were included. LS was confirmed by biopsy or by the validated CSS (clinical scoring system of vulvar LS). (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 8, 2023 Category: OBGYN Authors: Elke Krause, Stephanie Neumann, Marina Maier, Sara Imboden, Laura Knabben, Michael D. Mueller, Annette Kuhn Tags: Full length article Source Type: research
Vulvar vestibular papillomatosis: A diagnostic conundrum
We present a 19-year-old girl with a history of “small itchy growths” on the vulva for 2 months without any associated discharge. These lesions were causing significant anxiety to the patient. Cutaneous examination revealed multiple, uniformly arranged, skin-colored, monomorphic micropapillae on the inner aspect of the labia minora. Biopsy showed mucosal hyperplasia with papillomatosis and loosely arranged subdermal tissue, no koilocytes were spotted. The diagnosis of vulvar VP was made. We want to highlight this clinical entity as most dermatologists are not familiar with this benign condition an...
Source: Indian Journal of Sexually Transmitted Diseases - June 6, 2023 Category: Infectious Diseases Authors: Farhat Khan Akansha Chadha Chitra Nayak Atul Dongre Source Type: research
