Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons.
Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Declan Doogan of Juvenescence Presenting at Investing in the Age of Longevity
Investing in the Age of Longevity was an event held in London earlier this year as a part of the Longevity Week, a chance for Jim Mellon and the rest of the Juvenescence team to present their thesis on the longevity industry to the investor community - that this is an enormous opportunity to both greatly improve the human condition and generate returns on investment. A number of companies were there to present, as examples of the work on slowing and reversing aging presently taking place, and I was graciously invited to discuss the latest developments at Repair Biotechnologies. The presentations from the event have been po...
Source: Fight Aging! - December 16, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
10 Skincare Tips That ’ll Transform Your Skin
Conclusion:
The above are the ten basic skincare routines that will transform your skin. Understand that no product will show instant results and magically transform your skin. It takes time. Do a patch test before starting any new product for your face. The weather is a significant factor that has to be considered while choosing cleansers, toners, and moisturizers. Lastly, keep yourself hydrated by drinking water.
You've read 10 Skincare Tips That’ll Transform Your Skin, originally posted on Pick the Brain | Motivation and Self Improvement. If you've enjoyed this, please visit our site for more inspirational art...
Source: PickTheBrain | Motivation and Self Improvement - December 9, 2019 Category: Consumer Health News Authors: rossgeller Tags: featured health and fitness beauty feel beautiful Source Type: blogs
Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications.
To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence?
https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/
Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable proces...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Werner Syndrome is Strongly Mediated by Mitochondrial Dysfunction
We report that Werner syndrome (WS) is associated with a significant mitochondrial dysfunction, mainly manifested as defective mitophagy. This is reflected in lower NAD+ levels across species from worms to humans. NAD+ supplementation improves mitochondrial function and other age-related metabolic outcomes. Mitochondrial disease can manifest itself in multiple clinical outcomes amongst which neurodegeneration and impaired metabolism are common. Some features of WS may be explained by genomic instability due to mutation in the gene encoding the Werner protein (WRN), an important DNA helicase/exonuclease involved in DNA repa...
Source: Fight Aging! - November 28, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
10 Skincare Tips That ’ll Transform Your Skin.
Conclusion:
The above are the ten basic skincare routines that will transform your skin. Understand that no product will show instant results and magically transform your skin. It takes time. Do a patch test before starting any new product for your face. The weather is a significant factor that has to be considered while choosing cleansers, toners, and moisturizers. Lastly, keep yourself hydrated by drinking water.
You've read 10 Skincare Tips That’ll Transform Your Skin., originally posted on Pick the Brain | Motivation and Self Improvement. If you've enjoyed this, please visit our site for more inspirational ar...
Source: PickTheBrain | Motivation and Self Improvement - November 27, 2019 Category: Consumer Health News Authors: rossgeller Tags: health and fitness Uncategorized beauty feel beautiful Source Type: blogs
Fight Aging! Newsletter, November 18th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Poor Results from an Initial Human Trial of Nicotinamide Mononucleotide
Mitochondria are the power plants of the cell, responsible for packaging energy store molecules that power cellular processes. NAD+ is an essential metabolite for mitochondrial function, but levels decline with age. The proximate causes of this decline are fairly well mapped, and involve insufficient resources in a variety of pathways for synthesis or recycling of NAD+. The deeper reasons are poorly understood, however, meaning how these pathway issues emerge from the underlying molecular damage to cells and tissues that causes aging. Ways to force an increase in NAD+ levels have been shown to improve mitochondrial functio...
Source: Fight Aging! - November 11, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 11th 2019
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health.
Towards a Rigorous Definition of Cellular Senescence
https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/
The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the producti...
Source: Fight Aging! - November 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Investigation of Adverse Effects of Nicotinamide Riboside Supplementation
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health.
Link: https://doi.org/10.3390/nu11102439 (Source: Fight Aging!)
Source: Fight Aging! - November 5, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Hydroquinone creams, Vitamins in hair and more – episode 196
On this episode of the Beauty Brains we answer a number of beauty product questions and talk about big companies and the brands they own.
Beauty Questions On today’s episode we answer your questions about
Are there any benefits in putting vitamins on hair?Does anything work better than hydroquinone for age spots?Do shave minimizing products work?Are film forming ingredients easy to wash off?
Beauty News
The Rise of Fancy Face Cream—for the Rest of Your Body
High end skincare companies are making powerful skin care creams for the body, not the face.
Dermatologist rant! – Not everything you...
Source: thebeautybrains.com - October 16, 2019 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast hydroquinone shaving skin lightening vitamins Source Type: blogs
Hydroquinone creams, Vitamins in hair and more – episode 196
On this episode of the Beauty Brains we answer a number of beauty product questions and talk about big companies and the brands they own.
Beauty Questions On today’s episode we answer your questions about
Are there any benefits in putting vitamins on hair?Does anything work better than hydroquinone for age spots?Do shave minimizing products work?Are film forming ingredients easy to wash off?
Beauty News
The Rise of Fancy Face Cream—for the Rest of Your Body
High end skincare companies are making powerful skin care creams for the body, not the face.
Dermatologist rant! – Not everything you...
Source: thebeautybrains.com - October 16, 2019 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast hydroquinone shaving skin lightening vitamins Source Type: blogs
Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health.
Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice
https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/
Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Data on Exercise as a Treatment for Age-Related Arterial Stiffness
In addition to its effect on muscle growth, exercise upregulates a range of maintenance processes, such as autophagy, that improve tissue function when maintained over the long term. Lack of exercise in later life accelerates the decline in muscle mass and strength, an issue that appears reversible to a degree that might surprise most people. A similar situation occurs with respect to stiffening of blood vessels, in that while much of this depends on mechanisms such as cross-linking and presence of senescent cells, some of the decline is a matter of being sedentary.
The interesting finding in the open access study n...
Source: Fight Aging! - October 7, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
