Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Injected Nicotinamide Riboside Upregulates NAD+ in Mice, But Metabolic Effects are Minimal
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Link: https://doi.org/10.1016/j.isci.2022.103863 (Source: Fight Aging!)
Source: Fight Aging! - March 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and her...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Discussing the Present State of Clinical Trials for Therapies that Target Mechanisms of Aging
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far. (Source: Fight Aging!)
Source: Fight Aging! - February 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning a...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Assessing the Ability of Urolithin A Supplementation to Improve Human Health via Increased Mitophagy
Mitophagy is the name given to cellular quality control mechanisms responsible for destroying worn and damaged mitochondria. Existing mitochondrial divide to make up the losses. Mitophagy is critical to mitochondrial function, but it declines in effectiveness with advancing age. A number of dietary supplements are thought to upregulate mitophagy in older individuals, thereby improving mitochondrial function and overall health. Urolithin A is one of them, various vitamin B3 derivatives such as nicotinamide riboside another, as well as mitoQ, SkQ1, and other mitochondrially targeted antioxidants. The mechanisms are varied, a...
Source: Fight Aging! - January 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
NAD+ Depletion Primes Cells for Inflammatory Behavior
Today's open access paper provides an interesting view on the age-related reduction in cellular NAD+ levels, a topic of interest in the longevity community these past years. Nicotinamide adenine dinucleotide (NAD) is an important piece of molecular machinery in the function of the electron transport chain in mitochondria. The primary role of mitochondria is to generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. NAD cycles between NAD+ and NADH during this process, and lower levels of NAD imply a growing dysfunction in cellular energy metabolism.
Separately, researchers h...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Mononucleotide Supplement Adjusts the Gut Microbiome
In today's open access paper, the authors report on their investigation of the effects of nicotinamide mononucleotide (NMN) supplementation on the gut microbiome in mice. The gut microbiome changes with age, exhibiting a loss of helpful populations that produce metabolites necessary to health, and the growth in harmful populations that provoke chronic inflammation. Rejuvenating the aged gut microbiome via fecal microbiota transplantation from a young individual has been shown to improve health and extend life in short-lived species. Thus there is some interest in evaluating the effects on the gut microbiome produced by int...
Source: Fight Aging! - December 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Review of Lifespan, the Book, and Some Confusion About Aging
David Sinclair works on areas of mitochondrial metabolism relevant to aging, sirtuins and NAD, and of late is involved in research into a novel understanding of the relationship between DNA repair and age-related epigenetic change, as well as the use of in vivo reprogramming as a way to reverse age-related epigenetic change. He is first and foremost an excellent self-promoter, however, a job that has come to includes authoring books such as Lifespan.
On balance, self-promotion seems a useful trait for people who work on projects of merit. It is a tough job to raise funds and build the necessary networks of allies to...
Source: Fight Aging! - December 9, 2021 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Small Human Study of Short Term Nicotinamide Mononucleotide Supplementation
Declining levels of NAD+ in cells is one of the proximate causes of loss of mitochondrial function with age. A number of approaches to increasing levels of NAD+ in cells involve using supplements that are derived from vitamin B3. Nicotinamide mononucleotide (NMN) is one of these, but has to date far less published human evidence for its effects than is the case for nicotinamide riboside (NR), making the small study noted here interesting. In general, the evidence for vitamin B3 derived compounds to increase NAD+ in older people is good, while the evidence for that increase to then produce benefits to health is mixed at bes...
Source: Fight Aging! - April 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
