Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration
https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signal...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Mononucleotide Supplementation Improves Neurovascular Function in Aged Mice
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Link: https://doi.org/10.1007/s11357-020-00165-5 (Source: Fight Aging!)
Source: Fight Aging! - February 25, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve.
A Comparison of Biological Age Measurement Approaches
https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/
Researchers here assess the performance of a range of approaches to measuring biologica...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Mononucleotide Supplementation Restores Lost Fertility in Aged Female Mice
Studies of the various approaches to raising NAD+ levels in aged mitochondria are a good illustration of the importance of the loss of mitochondrial function in degenerative aging. Researchers have studied this effect in numerous tissues and organs, with most such work examining muscle or the brain, both energy-hungry tissues and thus more dependent on their mitochondria for normal function. Today's open access paper is a study of mitochondrial function in a tissue that is less well studied in this context. The authors reporting that supplementation with nicotinamide mononucleotide (NMN) can restore lost fertility in old m...
Source: Fight Aging! - February 19, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is bakuchiol safe during pregnancy? episode 210
We’ve got a fully packed program today. We’ll be covering a couple of cosmetic science news stories, catching up from my hiatus and answering questions about…
Is silicone suffocating hair and causing hair loss?Do proteins in nail products strengthen nails?What is goat’s milk doing in soaps and more?What’s an affordable version of Skinceuticals Triple Lipid Restore?Is Bakuchiol safe during pregnancy?
LA trip chat – Eco well sustainable beauty panel
Beauty Science News #1
Is Deva curl making people’s hair fall out?
Revlon teams up with the EWG
Hallmark Channel rant
Question 1&...
Source: thebeautybrains.com - February 18, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging
Thymic Involution Contributes to Immunosenescence and Inflammaging
The Potential for Exosome Therapies to Treat Sarcopenia
Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
The Aging Retina, a Mirror of the Aging Brain
Evidence for Loss of Capillary Density to be Important in Heart Disease
Aspects of Immune System Aging Proceed More Rapidly in Men
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Transplantation of Senescent Cel...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Riboside Improves Hematopoiesis and Immune Cell Populations in Mice
Mitochondria are the power plants of the cell. They produce the chemical energy store molecule ATP that is used to power cellular operations. Unfortunately, mitochondrial function falters throughout the body with advancing age, and while this is harmful in all tissues, the effects are particularly problematic in energy-hungry tissues such as the muscle and brain. Research of recent years has implicated the loss of nicotinamide adenine dinucleotide (NAD+) in mitochondria in this process. Evidence suggests that loss of effectiveness in mitophagy, the process that recycles worn and damaged mitochondria, is the important issue...
Source: Fight Aging! - February 11, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 10th 2020
In conclusion, the concept of an epigenetic clock is compelling, but caution should be taken in interpreting associations with age acceleration. Association tests of age acceleration should include age as a covariate.
A Discussion of Recent Work on Allotopic Expression of Mitochondrial Genes at the SENS Research Foundation
https://www.fightaging.org/archives/2020/02/a-discussion-of-recent-work-on-allotopic-expression-of-mitochondrial-genes-at-the-sens-research-foundation/
A paper published last month outlines recent progress on allotopic expression of mitochondrial genes carried out by the SENS Research...
Source: Fight Aging! - February 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Efforts to Develop NAD+ Therapies to Reverse Age-Related Loss of Mitochondrial Function
Increasing levels of NAD+ in mitochondria, is a class of therapy that probably produces most of its benefits in animal models and human trials by restoring mitophagy. This may well be true of mitochondrially targeted antioxidants as well. Mitophagy removes damaged mitochondria, but is hampered by age-related changes in mitochondrial dynamics, among other reasons. Mitochondria are responsible for packaging chemical energy store molecules to power cellular operations. Mitochondrial function is critical to tissue function throughout the body, but is of particular note in the energy-hungry tissues of muscle and brain.
N...
Source: Fight Aging! - February 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Peptides in skin care – episode 208
Beauty questions answered today include
Is there a bar shampoo or bar conditioner that works as well as the ones out of a bottle?Why can’t everyone use retinol?Is sugaring dangerous? And does it work as well as waxing? Do peptides have an effect beyond moisturizing & is there a “best one” to pick?
Beauty Science News
Industry must take a wholistic approach to talking about ingredient safety
UV protection may not be enough for skin protection
Beauty Questions
Question 1 – Audio
Jennifer asks – Is it wishful thinking to hope that a bar shampoo or bar conditioner will ...
Source: thebeautybrains.com - January 30, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast peptide retinol shampoo Source Type: blogs
Peptides in skin care – episode 208
Beauty questions answered today include
Is there a bar shampoo or bar conditioner that works as well as the ones out of a bottle?Why can’t everyone use retinol?Is sugaring dangerous? And does it work as well as waxing? Do peptides have an effect beyond moisturizing & is there a “best one” to pick?
Beauty Science News
Industry must take a wholistic approach to talking about ingredient safety
UV protection may not be enough for skin protection
Beauty Questions
Question 1 – Audio
Jennifer asks – Is it wishful thinking to hope that a bar shampoo or bar conditioner will ...
Source: thebeautybrains.com - January 30, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast peptide retinol shampoo Source Type: blogs
Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free."
Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease
https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/
I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is ...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing a Few Approaches to Restoration of Muscle Stem Cell Function in Aged Tissues
There are many overlapping mechanisms involved in the age-related loss of stem cell function in muscle tissue that leads to loss of muscle mass and strength. To name a few: the mitochondrial dysfunction that occurs in all tissues, or the chronic inflammation produced by senescent cells and the aging immune system. The authors of this open access review paper choose to divide approaches to treatment of loss of muscle stem cell function, whether compensatory or actual rejuvenation, into those that affect stem cells versus those that affect the stem cell niche. Research has suggested that the fact that muscle stem cell popula...
Source: Fight Aging! - January 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 6th 2020
Conclusion
A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - January 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2019: Progress Towards the Treatment of Aging as a Medical Condition
Conclusion
A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - December 31, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
